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AZD6738 (Ceralasertib)

AZD6738 (Ceralasertib)

Name: AZD6738 (Ceralasertib)
SKU: A15794

目录号: A15794

ATR 抑制剂

Product Citations (2)

AZD6738 (Ceralasertib) Chemical Structure

CAS NO. 1352226-88-0

AZD6738是一种有效的ATR激酶抑制剂，对分离的酶的IC50为1 nM，对细胞中ATR激酶依赖性CHK1磷酸化的IC50为74 nM。

库存：现货

规格	价格	数量
5 mg	￥ 700.00
10 mg	￥ 1,050.00
25 mg	￥ 2,100.00

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生物活性

AZD6738是一种有效的ATR激酶抑制剂，对分离的酶的IC50为1 nM，对细胞中ATR激酶依赖性CHK1磷酸化的IC50为74 nM。

靶点信息

ATR
1 nM

溶解度 *

In vitro (25°C)	DMSO	75 mg/mL (181.81 mM)
	Water	Insoluble
	Ethanol	Warmed: 38 mg/mL
In vivo	5% DMSO+40% propylene glycol+ddH2O	9 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.24 mL	121.21 mL	242.42 mL
0.5 mM	4.85 mL	24.24 mL	48.48 mL
1 mM	2.42 mL	12.12 mL	24.24 mL
5 mM	0.48 mL	2.42 mL	4.85 mL

*The above data is based on the productmolecular weight 412.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15794
作用机制	Inhibitor (抑制剂)
M. Wt	412.51
Formula	C20H24N6O2S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1352226-88-0
Synonyms	AZD-6738, AZD 6738
SMILES	C[C@H]1N(C2=NC(C3=C4C(NC=C4)=NC=C3)=NC(C5([S@](=O)(C)=N)CC5)=C2)CCOC1