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AZD8330是新型，选择性，非ATP竞争性MEK 1/2抑制剂，IC50为7 nM。阶段1。
靶点信息
| ERK phosphorylation | MEK1/2 | |||
| 0.4 nM | 7 nM |
| In vitro (25°C) | DMSO | 88 mg/mL (190.79 mM) | |
| Water | Insoluble | ||
| Ethanol | 88 mg/mL (190.79 mM) | ||
| In vivo | 0.5% hydroxyethyl cellulose+0.1% Tween 80 | 28 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.68 mL | 108.41 mL | 216.83 mL |
| 0.5 mM | 4.34 mL | 21.68 mL | 43.37 mL |
| 1 mM | 2.17 mL | 10.84 mL | 21.68 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.34 mL |
*The above data is based on the productmolecular weight 461.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10115 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 461.2 |
| Formula | C16H17FIN3O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 869357-68-6 |
| Synonyms | AZD-8330 |
| SMILES | CC1=CC(=C(N(C1=O)C)NC2=C(C=C(C=C2)I)F)C(=O)NOCCO |
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