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BI-78D3

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生物活性

BI-78D3是一种竞争性JNK（c-Jun N端激酶）抑制剂（IC50 = 280 nM），其选择性是p38α的100倍以上，在mTOR和PI-3K上无活性。 BI 78D3抑制JIP1（JNK相互作用蛋白1）JNK结合（IC50 = 500 nM）。

靶点信息

JNK
280 nM

溶解度 *

In vitro	DMSO	89 mg/mL (234.6 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.39 mL	131.93 mL	263.85 mL
0.5 mM	5.28 mL	26.39 mL	52.77 mL
1 mM	2.64 mL	13.19 mL	26.39 mL
5 mM	0.53 mL	2.64 mL	5.28 mL

*The above data is based on the productmolecular weight 379. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13683
作用机制	Inhibitor (抑制剂)
M. Wt	379
Formula	C13H9N5O5S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	883065-90-5
Synonyms	BI 78D3, BI78D3
SMILES	C1COC2=C(O1)C=CC(=C2)N3C(=O)NN=C3SC4=NC=C(S4)[N+](=O)[O-]