BI-D1870

Name: BI-D1870
SKU: A12452

目录号: A12452

S6 Kinase 抑制剂

Product Citations (1)

BI-D1870 Chemical Structure

CAS NO. 501437-28-1

BI-D1870是体外和体内p90核糖体S6激酶（RSK）亚型的有效特异性抑制剂，在体外抑制RSK1，RSK2，RSK3和RSK4的IC50为10–30 nM。

库存：现货

规格	价格	数量
5 mg	￥ 770.00
10 mg	￥ 1,330.00
25 mg	￥ 2,380.00
50 mg	￥ 3,710.00
10mM * 1mL in DMSO	￥ 770.00

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产品详情

生物活性

BI-D1870是体外和体内p90核糖体S6激酶（RSK）亚型的有效特异性抑制剂，在体外抑制RSK1，RSK2，RSK3和RSK4的IC50为10–30 nM。

靶点信息

RSK4 (Cell-free assay)	RSK3 (Cell-free assay)	RSK2 (Cell-free assay)	RSK1 (Cell-free assay)
15 nM	18 nM	24 nM	31 nM

溶解度 *

In vitro (25°C)	DMSO	71 mg/mL (181.39 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	30% PEG400+0.5% Tween80+5% propylene glycol	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.55 mL	127.74 mL	255.49 mL
0.5 mM	5.11 mL	25.55 mL	51.1 mL
1 mM	2.55 mL	12.77 mL	25.55 mL
5 mM	0.51 mL	2.55 mL	5.11 mL

*The above data is based on the productmolecular weight 391.41. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12452
作用机制	Inhibitor (抑制剂)
M. Wt	391.41
Formula	C19H23F2N5O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	501437-28-1
SMILES	CC1C(=O)N(C2=CN=C(N=C2N1CCC(C)C)NC3=CC(=C(C(=C3)F)O)F)C