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BIX02188是一种有效的选择性MEK5抑制剂。
Targets
| Target | Value |
|---|---|
| MEK5 | IC50: 4.3nM |
| ERK5 | IC50: 810nM |
| TGFβR1 | IC50: 1.8μM |
| MEK1 | IC50: >6.3μM |
| MEK2 | IC50: >6.3μM |
| ERK1 | IC50: >6.3μM |
| JNK2 | IC50: >6.3μM |
| EGFR | IC50: >6.3μM |
| STK16 | IC50: >6.3μM |
| In vitro (25°C) | DMSO | 39 mg/mL (94.54 mM) | |
| Water | Insoluble | ||
| Ethanol | 3 mg/mL (7.27 mM) | ||
| In vivo | 5% DMSO+40% PEG 300+ddH2O | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.45 mL | 117.23 mL | 234.47 mL |
| 0.5 mM | 4.69 mL | 23.45 mL | 46.89 mL |
| 1 mM | 2.34 mL | 11.72 mL | 23.45 mL |
| 5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
*The above data is based on the productmolecular weight 426.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10150 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 426.5 |
| Formula | C26H26N4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1094614-84-2, 334949-59-6 |
| Synonyms | BIX-02188 |
| SMILES | CN(C)CC1=CC(=CC=C1)N/C(=C\2/C3=C(C=C(C=C3)C(=O)N)NC2=O)/C4=CC=CC=C4 |
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