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BMS-935177是一种有效的BTK抑制剂，具有多种激酶改善的激酶选择性和优异的口服暴露性。应该在自身免疫性疾病中提供有用的临床疗效。
| In vitro | DMSO | 88 mg/mL (175.1 mM) | |
| Water | Insoluble | ||
| Ethanol | 88 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.9 mL | 99.49 mL | 198.98 mL |
| 0.5 mM | 3.98 mL | 19.9 mL | 39.8 mL |
| 1 mM | 1.99 mL | 9.95 mL | 19.9 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.98 mL |
*The above data is based on the productmolecular weight 502.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16905 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 502.57 |
| Formula | C31H26N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1231889-53-4 |
| Synonyms | BMS935177, BMS 935177 |
| SMILES | O=C(C1=CC=C(C2=CC=CC(N3C(C4=C(C=CC=C4)N=C3)=O)=C2C)C5=C1NC6=C5C=CC(C(C)(O)C)=C6)N |
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