产品详情

生物活性

BMY 7378是5-HT1A部分激动剂和高亲和力α1D肾上腺素能受体拮抗剂。

Targets

Target	Value
5-HT1A	pIC50: 8.3
α1D-adrenoceptor	pki: 8.2
DopamineD2receptor	pIC50: 7.4
α2C-adrenoceptor	pki: 6.54
5-HT1C	pIC50: 6.4
5-HT1D	pIC50: 5.9
H1receptor	pIC50: 5.7
5-HT2	pIC50: 5.5
H2receptor	pIC50: 5.3
α2-adrenoceptor	pIC50: 5.1
β1-adrenoceptor	pIC50: 5.1
DopamineD1receptor	pIC50: 5
Nicotinicreceptor	pIC50: 4.9
β2-adrenoceptor	pIC50: <5.0
5-HT3	pIC50: <5.0
H3receptor	pIC50: <5.0
GABAAreceptor	pIC50: <5.0
GABABreceptor	pIC50: <5.0
MuscarinicM1receptor	pIC50: <5.0
MuscarinicM2receptor	pIC50: <5.0
MuscarinicM3receptor	pIC50: <5.0
NMDAreceptor	pIC50: <5.0
AT1receptor	pIC50: <5.0
AT2receptor	pIC50: <5.0
EndothelinReceptor	pIC50: <5.0
AdenosineA1receptor	pIC50: <5.0
AdenosineA2receptor	pIC50: <5.0

溶解度 *

In vitro (25°C)	DMSO	81 mg/mL (176.69 mM)
	Water	81 mg/mL (176.69 mM)
	Ethanol	18 mg/mL (39.26 mM)
In vivo	Saline	14 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.81 mL	109.07 mL	218.14 mL
0.5 mM	4.36 mL	21.81 mL	43.63 mL
1 mM	2.18 mL	10.91 mL	21.81 mL
5 mM	0.44 mL	2.18 mL	4.36 mL

*The above data is based on the productmolecular weight 458.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11208
作用机制	Agonist (激动剂)
M. Wt	458.42
Formula	C22H31N3O3.2HCl
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	21102-95-4
Synonyms	BMY7378, BMY-7378
SMILES	COC1=CC=CC=C1N2CCN(CC2)CCN3C(=O)CC4(CCCC4)CC3=O.Cl.Cl