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Bosentan是内皮素-1（ET-A）和内皮素B（ET-B）受体的竞争性拮抗剂。
靶点信息
| ET-A | ET-B | |||
| 4.7 nM(Ki) | 95 nM(Ki) |
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.13 mL | 90.65 mL | 181.29 mL |
| 0.5 mM | 3.63 mL | 18.13 mL | 36.26 mL |
| 1 mM | 1.81 mL | 9.06 mL | 18.13 mL |
| 5 mM | 0.36 mL | 1.81 mL | 3.63 mL |
*The above data is based on the productmolecular weight 551.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11091 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 551.6 |
| Formula | C27H29N5O6S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 147536-97-8 |
| SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)NC2=C(C(=NC(=N2)C3=NC=CC=N3)OCCO)OC4=CC=CC=C4OC |
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