BYL719 (Alpelisib)

Name: BYL719 (Alpelisib)
SKU: A11328

目录号: A11328

PI3K 抑制剂

Product Citations (3)

BYL719 (Alpelisib) Chemical Structure

CAS NO. 1217486-61-7

BYL719 (Alpelisib)是一种口服生物可利用的磷脂酰肌醇3-激酶(PI3K)抑制剂，抑制 p110α/p110γ/p110δ/p110β 的 IC50 分别为 5 nM，250 nM，290 nM，1200 nM 。具有潜在的抗肿瘤活性。

库存：现货

规格	价格	数量
5 mg	￥ 350.00
10 mg	￥ 525.00
25 mg	￥ 630.00
50 mg	￥ 770.00
10mM * 1mL in DMSO	￥ 350.00

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产品详情

生物活性

靶点信息

PI3Kα (Cell-free assay)
5 nM

溶解度 *

In vitro (25°C)	DMSO	77 mg/mL (174.41 mM)
	Water	Insoluble
	Ethanol	2 mg/mL (4.53 mM)
In vivo	5%DMSO+40%PEG300+5%Tween80+50%ddH2O	4.1 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.65 mL	113.25 mL	226.5 mL
0.5 mM	4.53 mL	22.65 mL	45.3 mL
1 mM	2.27 mL	11.33 mL	22.65 mL
5 mM	0.45 mL	2.27 mL	4.53 mL

*The above data is based on the productmolecular weight 441.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11328
作用机制	Inhibitor (抑制剂)
M. Wt	441.5
Formula	C19H22F3N5O2S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1217486-61-7
Synonyms	BYL-719
SMILES	CC1=C(SC(=N1)NC(=O)N2CCC[C@H]2C(=O)N)C3=CC(=NC=C3)C(C)(C)C(F)(F)F