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C188-9是一种有效的STAT3抑制剂，它以高亲和力（KD = 4.7±0.4 nM）与STAT3结合。C188-9在小鼠中具有良好的耐受性，显示出良好的口服生物利用度，并且集中在肿瘤中。
| In vitro | DMSO | 81 mg/mL (171.78 mM) | |
| Water | Insoluble | ||
| Ethanol | 5 mg/mL (10.6 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.21 mL | 106.04 mL | 212.08 mL |
| 0.5 mM | 4.24 mL | 21.21 mL | 42.42 mL |
| 1 mM | 2.12 mL | 10.6 mL | 21.21 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
*The above data is based on the productmolecular weight 471.52. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16804 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 471.52 |
| Formula | C27H21NO5S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 432001-19-9 |
| Synonyms | C 188-9; C-188-9; C-1889; C1889; C 1889; C-1889; F0808-0084; |
| SMILES | O=S(C1=CC=C(OC)C=C1)(NC2=C3C=CC=CC3=C(O)C(C4=C5C=CC=CC5=CC=C4O)=C2)=O |
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