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CA-4948是一种有效的，口服活性的白介素1受体相关激酶4（IRAK4）抑制剂。与GBC-DLBCL和ABC/GCB DLBCL PDX模型相比，CA-4948在所测试的五个ABC-DLBCL PDX模型中的四个模型中显示出最大的功效。
| In vitro | DMSO | 27 mg/mL (64.68 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.96 mL | 119.78 mL | 239.56 mL |
| 0.5 mM | 4.79 mL | 23.96 mL | 47.91 mL |
| 1 mM | 2.4 mL | 11.98 mL | 23.96 mL |
| 5 mM | 0.48 mL | 2.4 mL | 4.79 mL |
*The above data is based on the productmolecular weight 417.43. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A17005 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 417.43 |
| Formula | C21H19N7O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1801343-74-7 |
| Synonyms | CA 4948, CA4948 |
| SMILES | O=C(C1=CC=CC(C2=CC=C(N)N=C2)=N1)NC3=CN=C4C(OC(N5CCOCC5)=N4)=C3 |
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