Canagliflozin

Name: Canagliflozin
SKU: A11100

目录号: A11100

SGLT2 抑制剂

Product Citations (2)

Canagliflozin Chemical Structure

CAS NO. 842133-18-0

canagliflozin是2型亚钠葡萄糖转运蛋白（SGLT2）的抑制剂,作用于hSGLT2，无细胞试验中IC50为2.2 nM，比作用于hSGLT1选择性高413倍。

库存：现货

规格	价格	数量
5 mg	￥ 350.00
10 mg	￥ 490.00
50 mg	￥ 700.00
100 mg	￥ 875.00
10mM * 1mL in DMSO	￥ 385.00

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生物活性

canagliflozin是2型亚钠葡萄糖转运蛋白（SGLT2）的抑制剂,作用于hSGLT2，无细胞试验中IC50为2.2 nM，比作用于hSGLT1选择性高413倍。

靶点信息

mSGLT2 (Cell-free assay)	rSGLT2 (Cell-free assay)	hSGLT2 (Cell-free assay)
2 nM	3.7 nM	4.4 nM

溶解度 *

In vitro (25°C)	DMSO	79 mg/mL (177.71 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC+0.25% Tween 80	17 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.5 mL	112.49 mL	224.97 mL
0.5 mM	4.5 mL	22.5 mL	44.99 mL
1 mM	2.25 mL	11.25 mL	22.5 mL
5 mM	0.45 mL	2.25 mL	4.5 mL

*The above data is based on the productmolecular weight 444.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11100
作用机制	Inhibitor (抑制剂)
M. Wt	444.5
Formula	C24H25FO5S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	842133-18-0
SMILES	CC1=C(C=C(C=C1)[C@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)CC3=CC=C(S3)C4=CC=C(C=C4)F