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α4β1/α4β7 integrin 拮抗剂
Firategrast (SB 683699)是一种口服可生物利用的alpha4 beta1/alpha4 beta7整联蛋白拮抗剂,旨在减少淋巴细胞向中枢神经系统(CNS)的运输。
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- Higuchi S, .et al. Inhibition of the integrin signal constitutes a mouse iPS cell niche, Dev Growth Differ, 2016, Sep;58(7):586-99 PMID: 27633818
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integrin α5β1 antagonist
ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
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integrin α5β1 antagonist
ATN-161 is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
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αvβ3 integrin antagonist
MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM.
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integrin αvβ3 antagonist
Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent.
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Integrin receptor antagonist
GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM.
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