“alpha ergocryptine”的搜索结果
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alpha1/beta adrenergic receptors 拮抗剂
Labetalol HCl是选择性α1-肾上腺素能受体和非选择性β-肾上腺素能受体的双重拮抗剂。
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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
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5-HT2 receptor antagonist
Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors.
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alpha-1A/alpha-1B-adrenoceptor 拮抗剂
Tamsulosin是一种α1a-选择性α受体阻滞剂,用于对症治疗前列腺增生(BPH)。
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Dopamine D4 receptor antagonist
NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM).
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LPA5 antagonist
AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia.
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Dopamine receptor antagonist
Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
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α1 adrenoreceptor 拮抗剂
Urapidil是一种α1肾上腺素受体拮抗剂和5-HT1A受体激动剂。
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α2-adrenergic receptor 拮抗剂
Rauwolscine是一种天然生物碱,具有选择性和可逆性α2肾上腺素能受体拮抗剂(Ki = 12 nM)。
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α2 adrenergic receptor 拮抗剂
Atipamezole hydrochloride是一种选择性α2肾上腺素受体拮抗剂(α2A、α2B、α2C、α1A和α1B受体的Ki值分别为1.1、1.0、0.89、1300和6500nm)。已经被证明是大脑的渗透剂。
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