“alpha ergocryptine”的搜索结果
-
alpha1/beta adrenergic receptors 拮抗剂
Labetalol HCl是选择性α1-肾上腺素能受体和非选择性β-肾上腺素能受体的双重拮抗剂。
了解更多
- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
-
α4β1/α4β7 integrin 拮抗剂
Firategrast (SB 683699)是一种口服可生物利用的alpha4 beta1/alpha4 beta7整联蛋白拮抗剂,旨在减少淋巴细胞向中枢神经系统(CNS)的运输。
了解更多
- Higuchi S, .et al. Inhibition of the integrin signal constitutes a mouse iPS cell niche, Dev Growth Differ, 2016, Sep;58(7):586-99 PMID: 27633818
-
Androgen 拮抗剂
17 alpha-propionate是一种新型的局部和外周选择性雄激素拮抗剂。
了解更多
-
PPAR-α antagonist
NXT629 is a potent, selective, and competitive PPAR-α antagonist, with an IC50 of 77 nM for human PPARα, shows high selectivity over other nuclear hormone receptor, such as PPARδ, PPARγ, ERβ, GR and TRβ, IC50s are 6.0, 15, 15.2, 32.5 and >100 μM, respectively.
了解更多
-
5-HT2 receptor antagonist
Ritanserin (R 55667) is a highly potent, relatively selective, orally active, long acting antagonist of 5-HT2 receptor, with an IC50 of 0.9 nM, less active on Histamine H1, Dopamine D2, Adrenergic α1, Adrenergic α2 receptors.
了解更多
-
PPARα antagonist
GW 6471 is a potent PPARα antagonist.
了解更多
-
estrogen receptor (ERα) antagonist
AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with IC50 of 0.28 nM. AZD9496 maleate is an orally bioavailable selective oestrogen receptor degrader (SERD).
了解更多
-
RXRα antagonist
β-Apo-13-carotenone D3 is the deuterium labeled β-Apo-13-carotenone. β-Apo-13-carotenone (D'Orenone) is a naturally occurring β-apocarotenoid functioned as an antagonist of RXRα.
了解更多
-
integrin α5β1 antagonist
ATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
了解更多
-
α2-adrenoceptor antagonist
Atipamezole is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM.
了解更多
-
integrin α5β1 antagonist
ATN-161 is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model.
了解更多
-
αvβ3 integrin antagonist
MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM.
了解更多
-
integrin αvβ3 antagonist
Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent.
了解更多
-
α2 adrenoceptor antagonist
Piperoxan hydrochloride is an α2 adrenoceptor antagonist.
了解更多
-
alpha-1A/alpha-1B-adrenoceptor 拮抗剂
Tamsulosin是一种α1a-选择性α受体阻滞剂,用于对症治疗前列腺增生(BPH)。
了解更多
-
glutamate receptor subtype antagonist
Zonampanel (YM 872) is a selective antagonist of the glutamate receptor subtype, α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor.
了解更多
-
Integrin receptor antagonist
GLPG0187 is a broad spectrum integrin receptor antagonist with antitumor activity; inhibits αvβ1-integrin with an IC50 of 1.3 nM.
了解更多
-
Dopamine D4 receptor antagonist
NRA-0160 is a selective dopamine D4 receptor antagonist, with a Ki value of 0.48 nM and with negligible affinity for dopamine D2 receptor (Ki: >10000 nM), D3 receptor (Ki: 39 nM), rat 5-HT2A receptor (Ki: 180 nM) and rat α1 adrenoceptor (Ki: 237 nM).
了解更多
-
LPA5 antagonist
AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia.
了解更多
-
neuropeptide Y1 receptor antagonist
BMS-193885 is a potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over ??1, α1, Y2, Y4 and Y5 receptors respectively.
了解更多
-
Dopamine receptor antagonist
Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
了解更多
-
α1 adrenoreceptor 拮抗剂
Urapidil是一种α1肾上腺素受体拮抗剂和5-HT1A受体激动剂。
了解更多
-
α1A 拮抗剂
RS 17053 HCl是α1A受体拮抗剂,对α1A受体具有很高的亲和力(pKi和pA2估计为9.1-9.9),选择性比α1B和α1D亚型高30-100倍(pKi和pA2估计为7.7- 7.8)。
了解更多
-
α2-adrenergic receptor 拮抗剂
Rauwolscine是一种天然生物碱,具有选择性和可逆性α2肾上腺素能受体拮抗剂(Ki = 12 nM)。
了解更多
-
α2 adrenergic receptor 拮抗剂
Atipamezole hydrochloride是一种选择性α2肾上腺素受体拮抗剂(α2A、α2B、α2C、α1A和α1B受体的Ki值分别为1.1、1.0、0.89、1300和6500nm)。已经被证明是大脑的渗透剂。
了解更多