Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a selective agonist at GABAA receptors that contain α4-δ subunits, and has anxiolytic and sedative effects. 了解更多

Baclofen is a GABA agonist specific for GABA-B receptors. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission. 了解更多

Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome. 了解更多

U-101017 is a partial agonist of benzodiazepine receptor and GABAA receptor, with anxiolytic effects. 了解更多

CP-409092 hydrochloride is a partial agonist of GABAA receptor, with anti-anxiety activity. 了解更多

L-655708 is a potent α5 subunit-selective GABAA receptor inverse agonist (Ki = 0.45 nM). 了解更多

(R)-Baclofen(STX209) is a selective GABAB receptor agonist. 了解更多

Acamprosate calcium(Campral EC) is a GABA receptor agonist and modulator of glutamatergic systems; reduces alcohol consumption in animal models of alcohol addiction. 了解更多

MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS. 了解更多

RWJ-51204 is a partial agonist of GABA(A) receptor, with Ki of 0.2-2 nM to the benzodiazepine site on GABA(A) receptors. 了解更多

CP-409092 is a partial agonist of GABAA receptor, with anti-anxiety activity. 了解更多

Tramiprosate, also known as homotaurine, is a gamma-Aminobutyric acid (GABA) receptor agonist and a glycosaminoglycan mimetic used in the treatment of Alzheimer's disease. 了解更多

Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist. 了解更多

THIP (Gaboxadol) is a selective δ-aminobutyric acid type A receptor (δ-GABAAR) agonist. 了解更多

Varenicline Hydrochloride (CP 526555 hydrochloride) is a high affinity, selective α4β2 nicotine acetylcholine receptor (nAChR) partial agonist and full α7 nAChR agonist. 了解更多

Afloqualone, also known as HQ-495, is a centrally acting muscle relaxant. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site. 了解更多

Bamaluzole是GABA受体激动剂。 了解更多

Piperazine是由六元环组成的有机化合物，该六元环在环的相对位置包含两个氮原子。 了解更多

Metanicotine是一种神经元的尼古丁受体激动剂，对α4β2亚型具有高选择性（Ki = 26 nM）。选择性是α7受体（Ki = 36000 nM）的1,000倍以上。 了解更多

Muscimol hydrobromide是抗抑郁药氟西汀的活性代谢产物，可抑制5-羟色胺的摄取，pKi值为7.35.1。诺氟西汀的S-对映体的5-羟色胺再摄取阻断效能比R-对映体高20倍（分别为pKis = 7.86与6.51）。 了解更多

Ibotenic Acid是最初从鹅膏菌属物种中分离出来的一种神经兴奋性氨基酸，它起着NMDA和代谢型谷氨酸受体激动剂的作用。 了解更多

AWD 131-138是一种新的低亲和力的部分苯二氮卓类受体激动剂，在啮齿动物模型中具有强大的抗惊厥和抗焦虑特性。 了解更多

AZD5423是新型的非甾体类糖皮质激素受体激动剂。 了解更多

NMDA是一种原型NMDA受体激动剂。 了解更多