DPI-3290 (Org 41793) is a potent and specific opioid receptors agonist with Ki values of 0.18 nM, 0.46 nM, and 0.62 nM for δ-, μ-, and κ-opioid receptors, respectively. 了解更多
CYT-1010 hydrochloride is a mu-opioid receptor agonist extracted from patent WO2013173730A2, with EC50s of 13.1 nM and 0.0053 nM on beta-arrestin recruitment and inhibition of cAMP production, respectively. 了解更多
Trimebutine Maleate is a drug with antimuscarinic and weak mu opioid agonist effects. Trimebutine Maleate modulates the calcium and potassium channels, relieves abdominal pain in patients with irritable bowel syndrome. 了解更多
Preeti Manandhar, .et al. Tapentadol shows lower intrinsic efficacy at μ receptor than morphine and oxycodone, Pharmacol Res Perspect, 2022, 10:e00921 PMID: 35084120
Li He, .et al. Pharmacological and genetic manipulations at the ?-opioid receptor reveal arrestin-3 engagement limits analgesic tolerance and does not exacerbate respiratory depression in mice, Neuropsychopharmacology, 2021, 13 July PMID: 34257415
Mark G Papich, .et al. Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection, Drug Deliv Transl Res, 2022, Feb;12(2):376-383 PMID: 34817831
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