“MK-2206 dihydrochloride”的搜索结果
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nAChR 激动剂
GTS-21 dihydrochloride (DMBX-A)是一种选择性的α7烟碱乙酰胆碱受体激动剂,最近已被确定为一种有希望的炎症治疗方法。
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- P Yamini, .et al. α7nAChR activation protects against oxidative stress, neuroinflammation and central insulin resistance in ICV-STZ induced sporadic Alzheimer's disease, Pharmacol Biochem Behav, 2022, Jun;217:173402 PMID: 35533773
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PPARγ 激动剂
Inolitazone dihydrochloride是一种新型的高亲和力PPARγ激动剂,可激活PPARγ,其EC50约为罗格列酮的EC50,对RIE细胞无影响。
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dopamine 激动剂
Dexpramipexole dihydrochloride是一种神经保护剂和弱非麦角灵多巴胺激动剂。
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CCR8 激动剂
ZK-756326是有效的,选择性的非肽CCR8趋化因子受体激动剂。ZK 756326抑制了CCR8配体I-309(CCL1)的结合,IC(50)值为1.8μM。
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Dopamine Receptor 激动剂
Pramipexole dihydrochloride monohyrate是非麦角灵类的多巴胺激动剂,适用于治疗早期帕金森氏病(PD)和不安腿综合征(RLS)。
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5-HT1A receptor agonist
Lesopitron dihydrochloride is a full and selective 5-HT1A receptor agonist with IC50 of 125 nM in rat hippocampal membranes.
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TLR7/8 agonist
TLR7/8 agonist 1 dihydrochloride is a toll-like receptor (TLR7)/TLR8 dual-agonistic imidazoquinoline.
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dopamine D4 receptor partial agonist
Ro 10-5824 dihydrochloride is a selective dopamine D4 receptor partial agonist, with Ki of 5.2 nM.
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