“alpha ergocryptine”的搜索结果
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PI3K 抑制剂
PI-103 Hydrochloride是对重组PI3K亚型p110alpha(IC50 = 2 nM),p110beta(IC50 = 3 nM),p110delta(IC50 = 3 nM)和p110gamma(IC50 = 15 nM)具有低IC50值的有效抑制剂,对mTOR的效力较低/DNA-PK,IC50为30 nM/23 nM。
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PI3K 抑制剂
A66的S对映异构体是PI 3-激酶(PIK3CA)的p110alpha亚型的有效抑制剂。无细胞试验中IC50为32 nM,作用于p110α比作用于其他I类PI3K亚型选择性高100多倍。
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alpha-Bisabolol is a nontoxic sesquiterpene alcohol present in natural essential oil, with anticancer activity. alpha-Bisabolol exerts selective anticancer effect on A549 NSCLC cells (IC50=15 μM) via induction of cell cycle arrest, mitochondrial apoptosis and inhibition of PI3K/Akt signalling pathways. alpha-Bisabolol also strongly induces apoptosis in glioma cells.
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PI3Kα 抑制剂
PI3K-alpha inhibitor 1 是从专利US/20120088764A1中提取的PI3Kα抑制剂,化合物243,IC50 <0.1uM,PI3Kα抑制剂1还抑制HDAC(0.1uM≤IC50≤1uM)。
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PI3Kα inhibitor
Alpelisib hydrochloride (BYL-719 hydrochloride) is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM, 250 nM, 290 nM and 1200 nM for p110α, p110γ, p110δ, and p110β, respectively.
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PI3Kα inhibitor
GDC-0326 is a potent and selective PI3Kα inhibitor with a Ki of 0.2 nM.
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PI3Kα inhibitor
GDC-0077 (RG6114) is a potent, orally available, and selective PI3Kα inhibitor (IC50=0.038 nM).
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GSK-3α/β inhibitor
CHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM.
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GSK-3α/β inhibitor
CHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases.
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PI3Kα/δ inhibitor
Pictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold).
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Syk/PI3K inhibitor
SRX3207 is an orally active and first-in-class dual Syk/PI3K inhibitor, with IC50 values of 10.7 nM and 861 nM for Syk and PI3Kα, respectively. SRX3207 relieves tumor immunosuppression.
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PI3K inhibitor
SF2523 is a highly selective and potent inhibitor of PI3K with IC50s of 34 nM, 158 nM, 9 nM, 241 nM and 280 nM for PI3Kα, PI3Kγ, DNA-PK, BRD4 and mTOR, respectively.
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- Virender Kumar, .et al. Polymeric nanomedicine for overcoming resistance mechanisms in hedgehog and Myc-amplified medulloblastoma, Biomaterials, 2021, Nov;278:121138 PMID: 34634662
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PI3K/mTOR inhibitor
NSC781406 is a highly potent PI3K and mTOR inhibitor with an IC50 of 2 nM for PI3Kα.
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Akt inhibitor
PF-AKT400 is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50=0.5 nM) than PKA (IC50=450 nM).
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PI3Kδ inhibitor
Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.
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dual PI3K and mTOR kinase inhibitor
Dactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2.
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mTOR 抑制剂
CC-223是一种有效的mTOR激酶抑制剂(IC50 = 16 nM),其敏感性是相关脂质激酶PI3K-alpha(IC50 = 4 uM)的> 150倍。
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