“leukotriene receptor”的搜索结果
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alpha-1 adrenergic receptors / mAChRs inhibitor
Anisodamine is an inhibitor of alpha-1 adrenergic receptors and mAChRs isolated from Chinese solanacea plant.
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mAChR agonist
Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.
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M3 receptors 抑制剂
Imidafenacin是一种有效的选择性M3受体抑制剂,Kb为0.317 nM。对M2受体的效力较低(IC50 = 4.13 nM)。
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Oxybutynin (Ditropan)是一种抗胆碱能药物,是一种竞争性的muscarinic acetylcholine receptorM1,M2,和M3拮抗剂,用于缓解尿道和膀胱疾病。
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muscarinic acetylcholine receptor (mAChR) antagonist
Tiotropium Bromide (BA679 BR) is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel.
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muscarinic receptor inhibitor
Darenzepine is a muscarinic receptor inhibitor extracted from patent US 20170095465 A1.
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mAChR agonist
Oxotremorine M iodide is a potent and non-selective muscarinic acetylcholine receptor (mAChR) agonist.
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mAChR M5 negative allosteric modulator
(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration.
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mAChR antagonist
mAChR-IN-1 is a potent muscarinic cholinergic receptor(mAChR) antagonist with IC50 of 17 nM.
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mAChR antagonist
mAChR-IN-1 hydrochloride is a potent muscarinic cholinergic receptor (mAChR) antagonist, with an IC50 of 17 nM.
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mAChR modulator
Rapacuronium bromide is an allosteric modulator of muscarinic acetylcholine receptor (mAChR).
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mAChR antagonist
Atropine methyl bromide, a muscarinic receptor (mAChR) antagonist, is a quaternary ammonium salt of atropine and a mydriatic for dilation of the pupil during ophthalmic examination. It is introduced for relieving pyloric spasm in infants for its highly polar nature. It penetrates less readily into the central nervous system than atropine.
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muscarinic receptor 拮抗剂
Revefenacin是正在研发中的有效,选择性毒蕈碱受体拮抗剂,可用于治疗COPD。
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Nicotinic receptor 激动剂
Metanicotine是一种神经元的尼古丁受体激动剂,对α4β2亚型具有高选择性(Ki = 26 nM)。选择性是α7受体(Ki = 36000 nM)的1,000倍以上。
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Muscarinic receptor 拮抗剂
Umeclidinium bromide (GSK573719A)是毒蕈碱受体拮抗剂,可用于治疗慢性阻塞性肺疾病(COPD)。
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muscarinic M(3) receptor 拮抗剂
PF-3635659是有效的毒蕈碱M3受体拮抗剂。
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Muscarinic receptor 激动剂
Bethanechol chloride是拟副交感神经的胆碱氨基甲酸酯,可选择性刺激毒蕈碱受体,而不会对烟碱样受体产生任何影响。
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NMDA receptor 拮抗剂
Orphenadrine柠檬酸盐是NMDA受体拮抗剂,Ki为6.0μM,还是HERG钾离子通道阻断剂。
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muscarinic receptor 拮抗剂
SVT-40776 (Tarafenacin)是新型M3毒蕈碱受体拮抗剂,用于治疗膀胱过度活动症。
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muscarinic M3 receptor antagoinst
Solifenacin succinate是毒蕈碱M3受体拮抗剂,用于治疗尿失禁。
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muscarinic receptor 拮抗剂
Tolterodine tartrate (Detrol LA)是毒蕈碱受体拮抗剂。
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Muscarinic receptor antagonist
Biperiden HCl是毒蕈碱受体拮抗剂,对M1亚型表现出一定的选择性。
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muscarinic receptor 拮抗剂
5-hydroxymethyl tolterodine (PNU 200577)是托特罗定的代谢产物,tolterodine是一种用于治疗尿失禁的毒蕈碱受体拮抗剂。
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