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12 个项目
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β-Sitosterol
Catalog No. A11015 -
Elacestrant
Catalog No. A12244 Estrogen receptor degraderElacestrant (RAD1901) is an orally available selective estrogen receptor degrader (SERD) with IC50s of 48 and 870 nM for ERα and ERβ, respectively. 了解更多 -
GDC-0927 Racemate
Catalog No. A21507 estrogen receptor degraderGDC-0927 Racemate (SRN-927 Racemate) is a degrader of estrogen receptor, potently inhibits ER-α activity, with an IC50 of 0.2 nM, and is used in the research of ER-related diseases. 了解更多 -
Epristeride
Catalog No. A18231 5 alpha-reductase inhibitorEpristeride is a selective and specific uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. 了解更多 -
PROTAC ER Degrader-3
Catalog No. A18519 PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). 了解更多 -
AZD9496 maleate
Catalog No. A21726 estrogen receptor (ERα) antagonistAZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with IC50 of 0.28 nM. AZD9496 maleate is an orally bioavailable selective oestrogen receptor degrader (SERD). 了解更多 -
17 alpha-propionate
Catalog No. A10009 -
Alpha-Naphthoflavone
Catalog No. A18474 aromatase inhibitorAlpha-Naphthoflavone is a synthetic flavonoid, acts as a potent and competitive aromatase inhibitor with an IC50 and a Ki of 0.5 and 0.2 μM, respectively. 了解更多 -
Dutasteride (Avodart)
Catalog No. A10338 dual 5alpha-reductase 抑制剂Dutasteride (Avodart)是双重的5-a还原酶抑制剂，可抑制睾丸激素转化为二氢睾丸激素（DHT）。 了解更多 -
PROTAC ERRα Degrader-1
Catalog No. A18910 ERRα DegraderPROTAC ERRα Degrader-1 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRα Degrader-1 is an estrogen-related receptor alpha (ERRa) degrader. 了解更多 -
PROTAC ERRα ligand 2
Catalog No. A18939 ERRα inverse agonistPROTAC ERRα ligand 2 is an estrogen-related receptor α (ERRα) inverse agonist with an IC50 of 5.67 nM. PROTAC ERRα ligand 2 (IC50=5.67 nM) displays a ~11-fold improved potency than XCT790 (IC50=61.3 nM). 了解更多
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- Estrogen Receptors (7)
- Androgen Receptors (1)
- 5-alpha-reductase (3)
- Aromatase (1)
- 作用机制
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- Inhibitor (抑制剂) (4)
- Agonist (激动剂) (2)
- Antagonist (拮抗剂) (2)
- Degrader (降解剂) (4)
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