“sb269970 hcl”的搜索结果

产品 1 到 50 共 325个

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  1. SB269970 HCl

    Catalog No. A11925
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    5-HT7 receptor 拮抗剂
    SB269970 HCl是有效的选择性5-HT7受体拮抗剂。 了解更多
  2. SB-269970 hydrochloride

    Catalog No. A21889
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    5-HT7 receptor antagonist
    SB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors. 了解更多
  3. P005672 HCl (Sarecycline HCl)

    Catalog No. A11283
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    P005672 HCl (Sarecycline HCl)是用于抗菌/消炎痤疮治疗的II期药物。 了解更多
  4. AMG-073 HCl (Cinacalcet HCl)

    Catalog No. A10219
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    CaSR activator
    AMG-073 HCl(Cinacalcet HCl)是一种用于治疗甲状旁腺功能亢进的化合物,称为拟钙剂,通过增加甲状旁腺钙敏感受体(CaR)对细胞外钙的敏感性来减少甲状旁腺激素(PTH)的合成和分泌 。 了解更多
  5. TP0427736 HCl

    Catalog No. A22382
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    ALK5 kinase activity inhibitor
    TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. 了解更多
  6. SB203186 HCl

    Catalog No. A22523
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    5-HT4 receptor antagonist
    SB203186 is potent 5-HT4 receptor antagonist. 了解更多
  7. MLN4924 (HCL Salt)

    Catalog No. A11499
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    NAE 抑制剂
    MLN4924 (HCL Salt)是一种有效,选择性的 NEDD8 活化酶 (NEDD8-activating enzyme) 抑制剂。 了解更多
  8. 17-DMAG HCl (Alvespimycin)

    Catalog No. A10011
    Hsp90 抑制剂
    17-DMAG HCl (Alvespimycin)是17-AAG和格尔德霉素的水溶性类似物,与Hsp90的ATP结合位点结合并抑制其伴侣活性。显示出比17-AAG更有效的抗肿瘤活性。 了解更多
  9. Prexasertib HCl

    Catalog No. A22156
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    ATP-competitive CHK1 inhibitor
    Prexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM respectively in cell-free assay. 了解更多
  10. SEL24-B489 HCl

    Catalog No. A22203
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    pan-PIM/FLT3 inhibitor
    SEL24-B489 HCl is a potent, dual pan-PIM/FLT3 inhibitor. 了解更多
  11. UK-371804 HCl

    Catalog No. A22379
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    uPA inhibitor
    UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). 了解更多
  12. AVN-101 HCl

    Catalog No. A22498
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    5-HT7 receptor antagonist
    AVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a milti-target drug candidate for the treatment of CNS disorders. 了解更多
  13. Varenicline HCl

    Catalog No. A22519
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    Varenicline is a nicotinic receptor partial agonist. 了解更多
  14. MK-212 HCl

    Catalog No. A22531
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    MK 212 hydrochloride is a 5-HT receptor agonist; displays selectivity for 5-HT2C over 5-HT2A (IC50 values are 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively). 了解更多
  15. Acecainide HCl

    Catalog No. A22660
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    Class III antiarrhythmic agent
    Acecainide, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide. Acecainide is a Class III antiarrhythmic agent. It can be given either intravenously or orally, and is eliminated primarily by renal excretion. 了解更多
  16. Ractopamine HCl

    Catalog No. A17372
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    beta-Adrenergic agonist
    Ractopamine HCl is a beta-Adrenergic agonist. It acts by being a full agonist at the TAAR1. 了解更多
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    SAR-7334 HCl

    Catalog No. A17237
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    TRPC6 inhibitor
    SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected. 了解更多
  17. Procyclidine HCl

    Catalog No. A17371
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    Muscarinic antagonist
    Procyclidine hydrochloride is a muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in Parkinsonism. 了解更多
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    TCS-OX2-29 HCl

    Catalog No. A17136
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    OX2 receptor 拮抗剂
    TCS-OX2-29 HCl是一种选择性OX2受体拮抗剂,IC50值为40 nM。 了解更多
  18. Anavex2-73 HCl

    Catalog No. A17145
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    ??1 激动剂
    Anavex2-73 HCl是毒蕈碱/中度sigma1受体激动剂,可减轻东pol碱和地佐西平引起的学习障碍。 了解更多
  19. S38093 HCl

    Catalog No. A17148
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    H3 receptors
    S38093 HCl是组胺H3受体的反向激动剂。 了解更多
  20. E6446 HCl

    Catalog No. A17149
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    E6446 HCl是核酸敏感TLR的合成拮抗剂。 了解更多
  21. Desformylflustrabromine HCl

    Catalog No. A17103
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    Desformylflustrabromine HCl是α4β2的正变构调节剂,也是肌肉型nAChR抑制剂。 了解更多
  22. RS 17053 HCl

    Catalog No. A16885
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    α1A 拮抗剂
    RS 17053 HCl是α1A受体拮抗剂,对α1A受体具有很高的亲和力(pKi和pA2估计为9.1-9.9),选择性比α1B和α1D亚型高30-100倍(pKi和pA2估计为7.7- 7.8)。 了解更多
  23. AZD1208 HCl

    Catalog No. A16927
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    PIM kinases 抑制剂
    AZD1208 HCl是一种新型的,口服可生物利用的高选择性PIM激酶抑制剂。 了解更多
  24. Ruboxistaurin (LY333531 HCl)

    Catalog No. A16604
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    PKCβ1 and PKCβ2 抑制剂
    LY333531是一种特异性β-蛋白激酶C的抑制剂。竞争性和可逆性抑制PKCβ1和PKCβ2,IC50值分别为4.7和5.9 nM。 了解更多
  25. A-438079 HCl

    Catalog No. A12597
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    P2X7 receptor 拮抗剂
    A-438079 HCl是一种竞争性P2X7受体拮抗剂(抑制人重组P2X7细胞系中Ca2+流入的pIC50 = 6.9)。在其他P2受体上没有活性(IC50 > 10 uM)。 了解更多
  26. APS-2-79 HCl

    Catalog No. A16175
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    KSR/Ras 抑制剂
    APS-2-79 HCl,稳定KSR(Ras激酶抑制剂)失活状态并拮抗致癌性Ras信号(IC50值为120 nM,对抗KSR2的ATP-生物素探针标记)的小分子。 了解更多
  27. RAD1901 HCl salt

    Catalog No. A15990
    SERD/SERM
    RAD1901 HCl salt是口服的选择性雌激素受体降解剂(SERD)和选择性雌激素受体调节剂(SERM),具有潜在的抗肿瘤活性和类似雌激素的活性。 了解更多
  28. Pardoprunox HCl (SLV-308)

    Catalog No. A11538
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    Pardoprunox HCl (SLV-308)是一种抗帕金森病药物,是多巴胺受体D2、D3和5-HT1A激动剂,用于治疗帕金森病。 了解更多
  29. TRV130 HCl (Oliceridine)

    Catalog No. A15444
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    u-opioid receptor 激动剂
    TRV130 HCl (Oliceridine)是一种新型的μ-opioid 受体(MOR)G蛋白偏向配体。诱导强大的G蛋白信号传导(pEC50 = 8.1),效力和功效与吗啡相似,但β-arrestin募集和受体内在化作用要低得多。 了解更多
  30. Afuresertib HCl

    Catalog No. A13030
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    AKT 抑制剂?
    Afuresertib HCl,也称为GSK2110183,是具有潜在抗肿瘤活性的丝氨酸/苏氨酸蛋白激酶Akt(蛋白激酶B)的生物利用抑制剂。它结合并抑制Akt的活性,这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导.PI3K/Akt信号传导途径的激活通常与肿瘤发生有关,PI3K/Akt信号传导失调可能有助于肿瘤对多种抗肿瘤药的耐药性。 了解更多
  31. SBE 13 HCl

    Catalog No. A14426
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    PLK 抑制剂
    SBE 13 HCl是PLK1的选择性抑制剂,对于PLK1,PLK3和PLK2,IC 50值分别为200pM,875nM和66μM。 了解更多
  32. Edivoxetine HCl

    Catalog No. A13865
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    norepinephrine reuptake 抑制剂
    Edivoxetine HCl是一种选择性去甲肾上腺素再摄取抑制剂。 了解更多
  33. Dexmedetomidine HCl

    Catalog No. A11846
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    alpha2-adrenoceptor 激动剂
    Dexmedetomidine hydrochloride是美托咪啶的活性异构体,它充当有效的,高度选择性的α2-AR(α2-肾上腺素受体)激动剂。 了解更多
  34. PX-478 HCl

    Catalog No. A14319
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    HIF-1alpha 抑制剂
    PX-478 HCl是HIF-1alpha抑制剂,也是具有潜在抗肿瘤活性小分子。PX-478对已建立的人类肿瘤异种移植物具有出色的活性,可提供具有HIF-1水平正相关的延长的生长延迟的肿瘤消退。PX-478是高度水溶性的分子,具有良好的i.v.,i.p.和p.o.抗肿瘤活性。 了解更多
  35. NSC-23766 HCl

    Catalog No. A13975
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    Rac GTPase 抑制剂
    NSC 23766是Rac特异性GEF TrioN和Tiam 1(IC50 = 50 uM)引起的Rac1激活的细胞可渗透性可逆抑制剂。 了解更多
  36. CX-6258 HCl

    Catalog No. A14275
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    Pan-PIM kinase 抑制剂
    CX-6258 HCl是一种有效的口服泛Pim激酶抑制剂,对Pim1,Pim2和Pim3的IC50为5 nM,25 nM和16 nM。 了解更多
  37. Almorexant HCl

    Catalog No. A14286
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    OX1/OX2 拮抗剂
    Almorexant HCl是一种活性双重食欲素受体拮抗剂,对OX1和OX2受体3的IC50为6.6 nM和3.4 nM。 了解更多
  38. Chloroprocaine HCl

    Catalog No. A14260
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    Chloroprocaine HCl是外科手术期间的局部麻醉剂。 了解更多
  39. Carteolol HCl

    Catalog No. A14258
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    β-adrenoceptor 拮抗剂
    Carteolol HCl是一种β-肾上腺素受体拮抗剂。 了解更多
  40. Arzoxifene HCl

    Catalog No. A13292
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    Arzoxifene HCl是Arzoxifene的盐酸盐,Arzoxifene是具有抗雌激素特性的合成芳族衍生物。Arzoxifene作为混合的雌激素激动剂/拮抗剂与雌激素受体结合。 了解更多
  41. Methacycline HCl (Physiomycine)

    Catalog No. A10574
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    Methacycline hydrochloride (Physiomycine)是一种四环素抗生素。 了解更多
  42. Procaterol HCl

    Catalog No. A11905
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    Procaterol HCl是Kp为8 nM的短效β2-肾上腺素能受体激动剂,用于治疗哮喘。 了解更多
  43. Prazosin HCl

    Catalog No. A11914
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    Prazosin HCl是一种α1和α2B肾上腺素受体拮抗剂。也是褪黑激素MT3受体的有效拮抗剂(Ki = 10.2 nM) 了解更多
  44. Ropinirole HCl

    Catalog No. A11916
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    Ropinirole Hydrochloride是一种多巴胺受体激动剂。 了解更多
  45. Duloxetine HCl

    Catalog No. A11717
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    Duloxetine Hydrochloride是一种5-羟色胺和去甲肾上腺素再摄取抑制剂(SNRI),Ki为 4.6 nM。用于治疗压力性尿失禁和抑郁症。 了解更多
  46. Moxonidine HCl

    Catalog No. A11741
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    imidazoline receptor 1 激动剂
    Moxonidine HCl是咪唑啉受体亚型1(I1)的选择性激动剂。Moxonidine引起交感神经系统活动的减少,因此导致血压的降低。 了解更多
  47. Besifloxacin HCl

    Catalog No. A11330
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    Besifloxacin HCl是第四代氟喹诺酮类抗生素。 了解更多
  48. Arbidol HCl

    Catalog No. A11663
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    Arbidol HCl是抗流感病毒治疗药物。Arbidol抑制膜融合。Arbidol HCl可防止病毒与目标宿主细胞之间的接触。病毒衣壳和靶细胞的细胞膜之间的融合被抑制。这可以防止病毒进入靶细胞,从而保护其免受感染。 了解更多

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