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￥ 0.00 “sb269970 hcl”的搜索结果
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SB269970 HCl
Catalog No. A11925 -
SB-269970 hydrochloride
Catalog No. A21889 5-HT7 receptor antagonistSB269970 hydrochloride (SB-269970A) is a hydrochloride salt form of SB-269970, which is a 5-HT7 receptor antagonist with the pKi of 8.3, exhibits >50-fold selectivity against other receptors. 了解更多 -
P005672 HCl (Sarecycline HCl)
Catalog No. A11283 P005672 HCl (Sarecycline HCl)是用于抗菌/消炎痤疮治疗的II期药物。 了解更多 -
AMG-073 HCl (Cinacalcet HCl)
Catalog No. A10219 CaSR activatorAMG-073 HCl（Cinacalcet HCl）是一种用于治疗甲状旁腺功能亢进的化合物，称为拟钙剂，通过增加甲状旁腺钙敏感受体（CaR）对细胞外钙的敏感性来减少甲状旁腺激素（PTH）的合成和分泌 。 了解更多 -
TP0427736 HCl
Catalog No. A22382 ALK5 kinase activity inhibitorTP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM. 了解更多 -
SB203186 HCl
Catalog No. A22523 -
MLN4924 (HCL Salt)
Catalog No. A11499 -
17-DMAG HCl (Alvespimycin)
Catalog No. A10011 Hsp90 抑制剂17-DMAG HCl (Alvespimycin)是17-AAG和格尔德霉素的水溶性类似物，与Hsp90的ATP结合位点结合并抑制其伴侣活性。显示出比17-AAG更有效的抗肿瘤活性。 了解更多 -
Prexasertib HCl
Catalog No. A22156 ATP-competitive CHK1 inhibitorPrexasertib (LY2606368) is an ATP-competitive CHK1 inhibitor with a Ki value of 0.9 nmol/L. For CHK2 and RSK, its IC50 values are 8 nM and 9 nM respectively in cell-free assay. 了解更多 -
SEL24-B489 HCl
Catalog No. A22203 -
UK-371804 HCl
Catalog No. A22379 uPA inhibitorUK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). 了解更多 -
AVN-101 HCl
Catalog No. A22498 5-HT7 receptor antagonistAVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a milti-target drug candidate for the treatment of CNS disorders. 了解更多 -
MK-212 HCl
Catalog No. A22531 MK 212 hydrochloride is a 5-HT receptor agonist; displays selectivity for 5-HT2C over 5-HT2A (IC50 values are 0.028 and 0.42 μM for human 5-HT2C and 5-HT2A receptors expressed in HEK293 cells respectively). 了解更多 -
Acecainide HCl
Catalog No. A22660 Class III antiarrhythmic agentAcecainide, also known as N-acetylprocainamide and ASL 601, is the N-acetylated metabolite of procainamide. Acecainide is a Class III antiarrhythmic agent. It can be given either intravenously or orally, and is eliminated primarily by renal excretion. 了解更多 -
Ractopamine HCl
Catalog No. A17372 beta-Adrenergic agonistRactopamine HCl is a beta-Adrenergic agonist. It acts by being a full agonist at the TAAR1. 了解更多 -
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最新产品
SAR-7334 HCl
Catalog No. A17237 TRPC6 inhibitorSAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected. 了解更多 -
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Procyclidine HCl
Catalog No. A17371 Muscarinic antagonistProcyclidine hydrochloride is a muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in Parkinsonism. 了解更多 -
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最新产品
TCS-OX2-29 HCl
Catalog No. A17136 -
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Anavex2-73 HCl
Catalog No. A17145 -
Desformylflustrabromine HCl
Catalog No. A17103 Desformylflustrabromine HCl是α4β2的正变构调节剂，也是肌肉型nAChR抑制剂。 了解更多 -
RS 17053 HCl
Catalog No. A16885 α1A 拮抗剂RS 17053 HCl是α1A受体拮抗剂，对α1A受体具有很高的亲和力（pKi和pA2估计为9.1-9.9），选择性比α1B和α1D亚型高30-100倍（pKi和pA2估计为7.7- 7.8）。 了解更多 -
AZD1208 HCl
Catalog No. A16927 -
Ruboxistaurin (LY333531 HCl)
Catalog No. A16604 PKCβ1 and PKCβ2 抑制剂LY333531是一种特异性β-蛋白激酶C的抑制剂。竞争性和可逆性抑制PKCβ1和PKCβ2，IC50值分别为4.7和5.9 nM。 了解更多 -
A-438079 HCl
Catalog No. A12597 P2X7 receptor 拮抗剂A-438079 HCl是一种竞争性P2X7受体拮抗剂（抑制人重组P2X7细胞系中Ca2+流入的pIC50 = 6.9）。在其他P2受体上没有活性（IC50 > 10 uM）。 了解更多 -
APS-2-79 HCl
Catalog No. A16175 KSR/Ras 抑制剂APS-2-79 HCl，稳定KSR（Ras激酶抑制剂）失活状态并拮抗致癌性Ras信号（IC50值为120 nM，对抗KSR2的ATP-生物素探针标记）的小分子。 了解更多 -
RAD1901 HCl salt
Catalog No. A15990 SERD/SERMRAD1901 HCl salt是口服的选择性雌激素受体降解剂（SERD）和选择性雌激素受体调节剂（SERM），具有潜在的抗肿瘤活性和类似雌激素的活性。 了解更多 -
Pardoprunox HCl (SLV-308)
Catalog No. A11538 Pardoprunox HCl (SLV-308)是一种抗帕金森病药物，是多巴胺受体D2、D3和5-HT1A激动剂，用于治疗帕金森病。 了解更多 -
TRV130 HCl (Oliceridine)
Catalog No. A15444 u-opioid receptor 激动剂TRV130 HCl (Oliceridine)是一种新型的μ-opioid 受体（MOR）G蛋白偏向配体。诱导强大的G蛋白信号传导（pEC50 = 8.1），效力和功效与吗啡相似，但β-arrestin募集和受体内在化作用要低得多。 了解更多 -
Afuresertib HCl
Catalog No. A13030 AKT 抑制剂?Afuresertib HCl，也称为GSK2110183，是具有潜在抗肿瘤活性的丝氨酸/苏氨酸蛋白激酶Akt（蛋白激酶B）的生物利用抑制剂。它结合并抑制Akt的活性，这可能导致PI3K/Akt信号传导途径的抑制和肿瘤细胞的增殖以及肿瘤细胞凋亡的诱导.PI3K/Akt信号传导途径的激活通常与肿瘤发生有关，PI3K/Akt信号传导失调可能有助于肿瘤对多种抗肿瘤药的耐药性。 了解更多 -
SBE 13 HCl
Catalog No. A14426 PLK 抑制剂SBE 13 HCl是PLK1的选择性抑制剂，对于PLK1，PLK3和PLK2，IC 50值分别为200pM，875nM和66μM。 了解更多 -
Edivoxetine HCl
Catalog No. A13865 -
Dexmedetomidine HCl
Catalog No. A11846 alpha2-adrenoceptor 激动剂Dexmedetomidine hydrochloride是美托咪啶的活性异构体，它充当有效的，高度选择性的α2-AR（α2-肾上腺素受体）激动剂。 了解更多 -
PX-478 HCl
Catalog No. A14319 HIF-1alpha 抑制剂PX-478 HCl是HIF-1alpha抑制剂，也是具有潜在抗肿瘤活性小分子。PX-478对已建立的人类肿瘤异种移植物具有出色的活性，可提供具有HIF-1水平正相关的延长的生长延迟的肿瘤消退。PX-478是高度水溶性的分子，具有良好的i.v.，i.p.和p.o.抗肿瘤活性。 了解更多 -
NSC-23766 HCl
Catalog No. A13975 Rac GTPase 抑制剂NSC 23766是Rac特异性GEF TrioN和Tiam 1（IC50 = 50 uM）引起的Rac1激活的细胞可渗透性可逆抑制剂。 了解更多 -
CX-6258 HCl
Catalog No. A14275 Pan-PIM kinase 抑制剂CX-6258 HCl是一种有效的口服泛Pim激酶抑制剂，对Pim1，Pim2和Pim3的IC50为5 nM，25 nM和16 nM。 了解更多 -
Almorexant HCl
Catalog No. A14286 OX1/OX2 拮抗剂Almorexant HCl是一种活性双重食欲素受体拮抗剂，对OX1和OX2受体3的IC50为6.6 nM和3.4 nM。 了解更多 -
Arzoxifene HCl
Catalog No. A13292 Arzoxifene HCl是Arzoxifene的盐酸盐，Arzoxifene是具有抗雌激素特性的合成芳族衍生物。Arzoxifene作为混合的雌激素激动剂/拮抗剂与雌激素受体结合。 了解更多 -
Methacycline HCl (Physiomycine)
Catalog No. A10574 Methacycline hydrochloride (Physiomycine)是一种四环素抗生素。 了解更多 -
Duloxetine HCl
Catalog No. A11717 Duloxetine Hydrochloride是一种5-羟色胺和去甲肾上腺素再摄取抑制剂（SNRI），Ki为 4.6 nM。用于治疗压力性尿失禁和抑郁症。 了解更多 -
Moxonidine HCl
Catalog No. A11741 imidazoline receptor 1 激动剂Moxonidine HCl是咪唑啉受体亚型1（I1）的选择性激动剂。Moxonidine引起交感神经系统活动的减少，因此导致血压的降低。 了解更多 -
Arbidol HCl
Catalog No. A11663 Arbidol HCl是抗流感病毒治疗药物。Arbidol抑制膜融合。Arbidol HCl可防止病毒与目标宿主细胞之间的接触。病毒衣壳和靶细胞的细胞膜之间的融合被抑制。这可以防止病毒进入靶细胞，从而保护其免受感染。 了解更多
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