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5-alpha reductase 抑制剂
β-Sitosterol是一种植物甾醇,与胆固醇具有相似的化学结构。
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5 alpha-reductase inhibitor
Epristeride is a selective and specific uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2.
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dual 5alpha-reductase 抑制剂
Dutasteride (Avodart)是双重的5-a还原酶抑制剂,可抑制睾丸激素转化为二氢睾丸激素(DHT)。
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- Makoto Ishikawa, .et al. Additive neuroprotective effects of 24(S)-hydroxycholesterol and allopregnanolone in an ex vivo rat glaucoma model, Sci Rep, 2018, 8: 12851 PMID: 30150786
- Makoto Ishikawa, .et al. TSPO activation modulates the effects of high pressure in a rat ex vivo glaucoma model, Neuropharmacology, 2016, Dec; 111: 142-159 PMID: 27596950
- Makoto Ishikawa, .et al. Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model, Invest Ophthalmol Vis Sci., 2014, 55(12): 8531-8541 PMID: 25406290