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搜索结果：“glucagon receptor”

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Ki16425

Catalog No. A10501
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LPA Receptor 拮抗剂

ki16425是对LPA1和LPA3具有选择性的LPA受体拮抗剂，对人LPA1、LPA2和LPA3受体分别显示Ki值为0.34、6.5和0.93 μM。了解更多

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- Maria F Fernandes, .et al. Glucagon-like Peptide-1 Secretion Is Inhibited by Lysophosphatidic Acid, Int J Mol Sci, 2022, Apr 9;23(8):4163 PMID: 35456981
- Rieko Suenaga, .et al. Lateral access mechanism of LPA receptor probed by molecular dynamics simulation, PLoS One, 2022, Feb 3;17(2):e0263296 PMID: 35113924
- Inoue A, .et al. Illuminating G-Protein-Coupling Selectivity of GPCRs, Cell, 2019, Jun 13;177(7):1933-1947 PMID: 31160049
- Taniguchi R, .et al. Structural insights into ligand recognition by the lysophosphatidic acid receptor LPA6, Nature, 2017, Aug 17;548(7667):356-360 PMID: 28792932
- T. HASHIMOTO, .et al. Generalized pruritus in primary sclerosing cholangitis: implications of histamine release by lysophosphatidic acid., Br J Dermatol., 2015, Nov;173(5):1334-6 PMID: 26122943
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Ki16198

Catalog No. A11966
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LPA Receptor 拮抗剂

Ki16198是有效的LPA受体拮抗剂，可抑制LPA1和LPA3诱导的肌醇磷酸生成，Ki分别为0.34μM和0.93μM。了解更多

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AM095 free base

Catalog No. A14180
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LPA1 Receptor 拮抗剂

AM095 free base是一种新型，有效且口服可生物利用的溶血磷脂酸1型受体（LPA1）拮抗剂，对小鼠或重组人LPA1的IC50值分别为0.73和0.98μM。了解更多

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AM095

Catalog No. A13981
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LPA1 receptor 拮抗剂

AM095是一种有效的LPA1受体拮抗剂，因为它抑制GTPβS与过量表达重组人或小鼠LPA1的中国仓鼠卵巢（CHO）细胞膜结合，IC50值分别为0.98和0.73μM，并且没有LPA1激动作用。了解更多

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AM966

Catalog No. A13982
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LPA1 receptor 拮抗剂

AM966是LPA1受体（溶血磷脂酸受体）的高亲和力，选择性口服拮抗剂，IC50值为17 nM。了解更多

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- Maria F Fernandes, .et al. Glucagon-like Peptide-1 Secretion Is Inhibited by Lysophosphatidic Acid, Int J Mol Sci, 2022, Apr 9;23(8):4163 PMID: 35456981
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AS2717638

Catalog No. A18630
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LPA5 antagonist

AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia. 了解更多

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Radioprotectin-1

Catalog No. A18628
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LPA2 agonist

Radioprotectin-1 is a potent and specific nonlipid agonist of lysophosphatidic acid receptor 2 (LPA2), with an EC50 value of 25 nM for murine LPA2 subtype. 了解更多

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ONO-7300243

Catalog No. A16644
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LPA1 antagonist

ONO-7300243 is a novel, potent lysophosphatidic acid receptor 1 (LPA1) antagonist with IC50 of 0.16 μM. 了解更多

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LPA1 antagonist 1

Catalog No. A21301
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LPA1 antagonist

LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist with an IC50 of 25 nM. 了解更多

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BMS-986020 sodium

Catalog No. A21842
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LPA1 antagonist

BMS-986020 sodium is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist. 了解更多

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ASP6432

Catalog No. A18759
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LPA1 receptor antagonist

ASP6432 is a potent and selective Type 1 Lysophosphatidic Acid (LPA1) receptor antagonist. 了解更多

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