“angiotensin receptors”的搜索结果
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GABAB receptors 拮抗剂
2-Hydroxysaclofen对GABAB受体是一种有效的选择性拮抗剂。
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NMDA receptors 拮抗剂
NVP-AAM077抑制成年小鼠在脑室下区域和齿状回中的祖细胞增殖,并降低了齿状回中的新生细胞的存活。
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NMDA receptors Potentiator
CIQ是包含NR2C或NR2D亚基的NMDA受体的亚基选择性增强剂。
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M3 receptors 抑制剂
Imidafenacin是一种有效的选择性M3受体抑制剂,Kb为0.317 nM。对M2受体的效力较低(IC50 = 4.13 nM)。
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NMDA receptors blocker
RO 25-6981 maleate是含有NR2B亚基的NMDA受体的强效和选择性活性依赖性阻断剂。克隆的受体亚基组合NR1C/NR2B和NR1C/NR2A的IC50值分别为0.009和52 uM。
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NMDA receptors Blocker
Ro 25-6981是N-甲基-D-天冬氨酸(NMDA)受体的高亲和力,强效选择性阻断剂。
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GABA receptor agonist
Afloqualone, also known as HQ-495, is a centrally acting muscle relaxant. Afloqualone inhibits vestibular nystagmus probably due to both inhibition of selective polysynaptic transmission and enhancement of the effects of GABA and glycine in the lateral vestibular nucleus (LVN), and its GABA-enhancing effect is thought to be attributable to the increased sensitivity of GABA receptors of the LVN neuron site.
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mAChR agonist
Cevimeline (Evoxac) Hcl is a parasympathomimetic and muscarinic agonist, with particular effect on M3 receptors; used in the treatment of dry mouth associated with sjogren's syndrome.
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GABA agonist
Baclofen is a GABA agonist specific for GABA-B receptors. Baclofen is a synthetic chlorophenyl-butanoic acid derivative used to treat spasms due to spinal cord damage and multiple sclerosis, muscle-relaxing It acts at spinal and supraspinal sites, reducing excitatory transmission.
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partial agonist of GABA(A) receptor
RWJ-51204 is a partial agonist of GABA(A) receptor, with Ki of 0.2-2 nM to the benzodiazepine site on GABA(A) receptors.
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NMDA receptor antagonist
Ifenprodil tartrate is the atypical N-methyl-D-aspartate (NMDA) receptor antagonist, inhibits NMDA-induced currents at NR1A/NR2B receptors with high affinity (IC50 = 0.34 μM).
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GABA(A) receptor modulator
NS11394 is a potent and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors.
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P2Y12 receptors inhibitor
Cangrelor Tetrasodium is a high-affinity, reversible inhibitor of P2Y12 receptors that causes almost complete inhibition of ADP-induced platelet aggregate. It is a modified ATP derivative stable to enzymatic degradation. Unlike clopidogrel (Plavix), which is a prodrug, cangrelor is an active drug not requiring metabolic conversion.
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alpha-1 adrenergic receptors / mAChRs inhibitor
Anisodamine is an inhibitor of alpha-1 adrenergic receptors and mAChRs isolated from Chinese solanacea plant.
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GABAA receptors agonist
Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a selective agonist at GABAA receptors that contain α4-δ subunits, and has anxiolytic and sedative effects.
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purinergic P2X2/3 receptors antagonist
Minodronic acid (YM-529) is an antagonist of purinergic P2X2/3 receptors involved in pain.
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AChE /M1/M2/5HT4/I2 inhibitor
MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.
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