“alpha ergocryptine”的搜索结果
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PKCδ inhibitor
BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM).
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PKC inhibitor
LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma.
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PKC inhibitor
Ro 31-8220 is a potent PKC inhibitor, with IC50s of 5, 24, 14, 27, 24 and 23 nM for PKCα, PKCβI, PKCβII, PKCγ, PKCε and rat brain PKC, respectively.
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α-淀粉样前体蛋白调节剂是细胞可渗透的苯并内酰胺衍生的PKC激活剂(PKCα的Ki = 11.9 nM),即使在人类原纤维中为100 nM时,也能有效增强淀粉样前体蛋白(APP)的非淀粉样生成性α-加工。
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