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搜索结果：“Ligand-gated Ion Channels”

“Ligand-gated Ion Channels”的搜索结果

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RPR-260243

Catalog No. A20977
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HERG activator

RPR-260243 is a novel activator of HERG; modifies HERG currents inhibited by dofetilide (IC50 = 58 nM); little effect on HERG current amplitude and no significant effects on steady-state activation parameters or on channel inactivation processes. 了解更多

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GW 542573X

Catalog No. A13944
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KCa2.1 channels activator

GW 542573X是小电导Ca2+激活的K+通道（KCa2）的激活剂。了解更多

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Vernakalant HCl

Catalog No. A15275
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Ion channel blocker

Vernakalant hydrochloride是一种研究性混合离子通道阻滞剂，可以以2至5 mg/kg的剂量终止人的急性心房纤颤（AF），并且与现有药物相比，对房颤的选择性更高。在抗心律不齐的治疗中。了解更多

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- Joe Z.Zhang, .et al. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles, Cell Stem Cell, 2019, 24, 1-10
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ML418

Catalog No. A18426
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Kir7.1 potassium channels blocker

ML418 is a selective, sub-micromolar pore blocker of Kir7.1 potassium channels. The inward rectifier potassium (Kir) channel Kir7.1 (KCNJ13) is a key regulator of melanocortin signaling in the brain, electrolyte homeostasis in the eye, and uterine muscle contractility during pregnancy. 了解更多

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