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Xylometazoline HCl
Catalog No. A17251 α-adrenoceptor agonistXylometazoline hydrochloride is an α-adrenoceptor agonist commonly used as nasal decongestant. 了解更多 -
Lobeline hydrochloride
Catalog No. A17333 nicotinic receptor agonistLobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes. 了解更多 -
Methoxamine HCl
Catalog No. A17365 alpha-1 adrenergic agonistMethoxamine Hydrochloride is an alpha-1 adrenergic agonist that causes prolonged peripheral vasoconstriction. 了解更多 -
Moxisylyte hydrochloride
Catalog No. A17725 alpha-adrenergic blocking agentMoxisylyte hydrochloride is an alpha-adrenergic blocking agent that is used in Raynaud's disease. It is also used locally in the eye to reverse the mydriasis caused by phenylephrine and other sympathomimetic agents. 了解更多 -
Midodrine hydrochloride
Catalog No. A17757 Adrenergic alpha-1 agonistMidodrine hydrochloride is an ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. It improves clinical outcome of chronic hypotension. 了解更多 -
Lofexidine
Catalog No. A18151 α2-receptor agonistLofexidine is a selective α2-receptor agonist, commonly used to alleviate the physical symptoms of heroin and other types of opioid withdrawal. 了解更多 -
Anisodamine
Catalog No. A18215 alpha-1 adrenergic receptors / mAChRs inhibitorAnisodamine is an inhibitor of alpha-1 adrenergic receptors and mAChRs isolated from Chinese solanacea plant. 了解更多 -
Epristeride
Catalog No. A18231 5 alpha-reductase inhibitorEpristeride is a selective and specific uncompetitive inhibitor of human steroid 5 alpha-reductase isoform 2. 了解更多 -
(-)-(S)-B-973B
Catalog No. A18761 α7 nAChR modulator-)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR, with antinociceptive activity. 了解更多 -
6-Thioinosine
Catalog No. A18412 6-?Thioinosine (6TI) is a purine antimetabolite, acts as an anti-adipogenesis agent, downregulates mRNA levels of PPAR γ and C/EBPα, as well as PPAR γ target protein such as LPL, CD36, aP2, and LXRα. 了解更多 -
Pictilisib dimethanesulfonate
Catalog No. A11444 PI3Kα/δ inhibitorPictilisib dimethanesulfonate (GDC-0941 dimethanesulfonate) is a potent inhibitor of PI3Kα/δ with IC50 of 3 nM, with modest selectivity against p110β (11-fold) and p110γ (25-fold). 了解更多 -
3,5-Diiodothyropropionic acid
Catalog No. A19117 3,5-Diiodothyropropionic acid is a thyroid hormone analog, induces α-myosin heavy chain mRNA expression, binds to thyroid hormone receptor (TR), with Ka of 2.40 and 4.06 M-1 for TRα1 and TRβ1, respectively. 了解更多 -
PROTAC ER Degrader-3
Catalog No. A18519 PROTAC ER Degrader-3 is an intermediate for synthesis of PAC. PAC, consists the ADCs linker and PROTACs, conjugated to an antibody. PAC extracts from patent WO2017201449A1, compound LP2. PAC conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab). 了解更多 -
MD2-TLR4-IN-1
Catalog No. A18452 MD2-TLR4 inhibitorMD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively. 了解更多 -
STF-083010
Catalog No. A16720 IRE1α inhibitorSTF-083010 is a specific IRE1α inhibitor. STF-083010 inhibits Ire1 endonuclease activity, without affecting its kinase activity, after endoplasmic reticulum stress. 了解更多 -
ZINC13466751
Catalog No. A12522 HIF-1α/von Hippel-Lindau interaction inhibitorZINC13466751 is a potent inhibitor of HIF-1α/von Hippel-Lindau interaction with an IC50 of 2.0 ?M. 了解更多 -
Ercalcitriol
Catalog No. A11414 Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is an active metabolite of vitamin D2. 了解更多 -
β3-AR agonist 1
Catalog No. A12777 β3-adrenergic receptor agonistβ3-AR agonist 1 (compound 15) is a highly potent, selective, and orally available β3-adrenergic receptor (β3-AR) agonist (EC50=18 nM), being inactive to β1-, β2-, and α1A-AR (β1/β3, β2/β3, and α1A/β3>556-fold). 了解更多 -
Rivanicline oxalate
Catalog No. A11544 neuronal nicotinic receptor agonistRivanicline oxalate (RJR-2403 oxalate; (E)-Metanicotine oxalate) is a neuronal nicotinic receptor agonist, showing high selectivity for the α4β2 subtype (Ki=26 nM); > 1,000 fold selectivity than α7 receptors(Ki= 3.6 μM). 了解更多 -
Darbufelone mesylate
Catalog No. A11789 PGF2α/LTB4 production inhibitorDarbufelone mesylate (CI-1004 mesylate) is a dual inhibitor of cellular PGF2α and LTB4 production. Darbufelone potently inhibits PGHS-2 (IC50 = 0.19 μM) but is much less potent with PGHS-1 (IC50= 20 μM). 了解更多 -
Integrin Antagonists 27
Catalog No. A20895 integrin αvβ3 antagonistIntegrin Antagonists 27 is a small molecule integrin αvβ3 antagonist with binding affinity of 18 nM, as s novel anticancer agent. 了解更多 -
Emiglitate
Catalog No. A20917 α-glucoside hydrolase inhibitorEmiglitate (BAY o 1248) is a potent, selective and competitive inhibitor of α-glucoside hydrolase. 了解更多 -
Alfacalcidol-D6
Catalog No. A21142 VDR activatorAlfacalcidol-D6, a deuterated Alfacalcidol (1-hydroxycholecalciferol; Alpha D3; 1.alpha.-Hydroxyvitamin D3), is a non-selective VDR activator medication. 了解更多 -
Indeglitazar
Catalog No. A21148 PPAR agonistIndeglitazar is an orally available peroxisome proliferator-activated receptor (PPAR) pan-agonist for all three PPAR subtypes alpha (α), delta (δ) and gamma (γ). 了解更多 -
R1487 Hydrochloride
Catalog No. A21231 p38α inhibitorsR1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α. 了解更多 -
Basmisanil
Catalog No. A21321 GABAAα5 modulatorBasmisanil is a highly selective GABAAα5 negative allosteric modulator. 了解更多 -
Atipamezole
Catalog No. A21363 α2-adrenoceptor antagonistAtipamezole is a synthetic α2-adrenoceptor antagonist with a Ki of 1.6 nM. 了解更多 -
(Rac)-PT2399
Catalog No. A21376 HIF-2α inhibitor(Rac)-PT2399 (Compound 10e), the racemate of PT2399, acts as a potent and specific hypoxia-inducible factor 2a (HIF-2α) inhibitor with an IC50 of 0.01 μM. 了解更多 -
Peliglitazar racemate
Catalog No. A21411 dual α/γ PPAR activatorPeliglitazar racemate is the racemate of Peliglitazar. Peliglitazar is a novel dual α/γ PPAR activator. 了解更多 -
ATN-161 trifluoroacetate salt
Catalog No. A21412 integrin α5β1 antagonistATN-161 trifluoroacetate salt is a novel integrin α5β1 antagonist, which inhibits angiogenesis and growth of liver metastases in a murine model. 了解更多 -
CHIR-99021 monohydrochloride
Catalog No. A21430 GSK-3α/β inhibitorCHIR-99021 monohydrochloride (CT99021 monohydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM; > 500-fold selectivity for GSK-3 versus its closest homologs CDC2 and ERK2, as well as other protein kinases. 了解更多 -
CHIR-99021 trihydrochloride
Catalog No. A21436 GSK-3α/β inhibitorCHIR-99021 trihydrochloride (CT99021 trihydrochloride) is a GSK-3α/β inhibitor with IC50 of 10 nM/6.7 nM. 了解更多 -
PNU-282987 S enantiomer free base
Catalog No. A21459 PNU-282987 S enantiomer free base is the S-enantiomer of PNU-282987 free base. PNU-282987 is an α7 nicotinic acetylcholine receptor (α7 nAChR) agonist. 了解更多
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