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Nilotinib (AMN-107)
Catalog No. A10644 Bcr-Abl 抑制剂Nilotinib (AMN-107)是一种Bcr-Abl抑制剂，IC50小于30 nM。 了解更多 -
DCC-2036 (Rebastinib)
Catalog No. A11200 Bcr-Abl 抑制剂DCC-2036 (Rebastinib)是一种Bcr-Abl抑制剂，作用于Abl1(WT)和Abl1(T315I)，IC50分别为0.8 nM和4 nM，也抑制SRC， LYN， FGR， HCK， KDR， FLT3，和Tie-2，对c-Kit具有低的抑制活性。 了解更多 -
NVP-BHG712
Catalog No. A10661 EphB4 抑制剂NVP-BHG712是EphB4激酶的选择性抑制剂，在体外对EphB4的选择性超过40多种其他激酶（包括FGFR3）。 了解更多 -
Imatinib Mesylate
Catalog No. A10468 Bcr-Abl 抑制剂Imatinib mesylate是一种选择性酪氨酸激酶抑制剂，通过抑制KIT信号转导途径，在治疗胃肠间质瘤中诱导了持续的客观反应。 了解更多 -
Danusertib (PHA-739358)
Catalog No. A10715 Aurora 抑制剂Danusertib (PHA-739358)是Aurora A/B/C的Aurora激酶抑制剂，在无细胞分析中的IC50为13 nM/79nM/61 nM，对Abl，TrkA，c-RET和FGFR1以及更低的浓度具有中等效力 对Lck，VEGFR2/3，c-Kit，CDK2等有效。 了解更多 -
WP1130 (Degrasyn)
Catalog No. A10988 DUB/Bcr/ABL 抑制剂WP1130 (Degrasyn)是一种新型的选择性小分子去泛素酶抑制剂和Bcr/Abl破坏途径激活剂，可特异性和快速下调野生型和突变型Bcr/Abl蛋白，而不会影响慢性粒细胞性白血病（CML）中的bcr/abl基因表达细胞。 了解更多 -
Saracatinib (AZD0530)
Catalog No. A10108 Src/Abl 抑制剂Saracatinib (AZD0530)是一种高选择性，双特异性Src/Abl激酶抑制剂，对c-Src和Abl激酶的IC50分别为2.7和30 nM。 了解更多 -
Imatinib (Gleevec)
Catalog No. A10259 PDGFR 抑制剂Imatinib (Gleevec)是一种多靶点酪氨酸激酶抑制剂，抑制v-Abl、c-Kit和PDGFR的IC50分别为0.6，0.1和0.1 μM。 了解更多 -
ERDRP-0519
Catalog No. A22150 inhibitor of polymeraseERDRP-0519 is an orally available inhibitor of polymerase that shows efficacy against a lethal morbillivirus infection in a large animal model. 了解更多 -
GSK2983559 free acid
Catalog No. A22272 RIP2 kinase inhibitorGSK2983559 free acid (compound 3) is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor. 了解更多 -
JNJ-38158471
Catalog No. A22345 VEGFR-2 inhibitorJNJ-38158471 is a well tolerated, orally available, highly selective VEGFR-2 inhibitor, with an IC50 of 40 nM. JNJ-38158471 also inhibits Ret and Kit with IC50s of 180 and 500 nM, respectively. 了解更多 -
Timosaponin AIII
Catalog No. A22353 Inhibitor of U46619-induced Rat Platelet AggregationTimosaponin AIII is a potent Inhibitor of U46619-induced Rat Platelet Aggregation, Selectively Inhibiting TxA2-induced Platelet Activation, Preferably Suppressing TP-mediated Activation of Gq, not G12/13, Signaling Pathways. 了解更多 -
Dehydroascorbic acid
Catalog No. A12366 potent cerebroprotectionDehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke. 了解更多 -
Molnupiravir
Catalog No. A22165 broad-spectrum antiviral activityMolnupiravir (EIDD-2801, MK-4482) is an orally bioavailable prodrug of the ribonucleoside analog β-d-N4-hydroxycytidine (NHC; EIDD-1931) with broad-spectrum antiviral activity against SARS-CoV-2, MERS-CoV, SARS-CoV, and the causative agent of COVID-19. 了解更多 -
Conoidin A
Catalog No. A22167 cell permeable inhibitorConoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII). 了解更多 -
Vacuolin-1
Catalog No. A22213 cell-permeable lysosomal exocytosis inhibitorVacuolin-1 is a potent and cell-permeable lysosomal exocytosis inhibitor. 了解更多 -
S29434
Catalog No. A22217 inhibitor of quinone reductase 2 (QR2)S29434 (NMDPEF) is a potent, competitive, selective and cell-permeable inhibitor of quinone reductase 2 (QR2), with IC50s ranging from 5 to 16 nM for human QR2 at different organizational levels, and has good selectivity for QR2 over QR1. 了解更多 -
Almonertinib
Catalog No. A22232 EGFR inhibitorAlmonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. 了解更多 -
Quisinostat dihydrochloride
Catalog No. A22453 pan-HDAC inhibitorQuisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC50s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively. Quisinostat dihydrochloride has a broad spectrum antitumoral activity. 了解更多 -
PF-06679142
Catalog No. A22484 AMPK activatorPF-06679142 is a potent AMPK activator. PF-06679142 exhibited robust activation of AMPK in rat kidneys as well as desirable oral absorption, low plasma clearance, and negligible renal clearance in preclinical species. 了解更多 -
Emavusertib
Catalog No. A22489 Emavusertib, also known as CA-4948 is a potent IRAK4/FLT3 inhibitor with anti-tumor activity. CA-4948 demonstrated good cellular activity in ABC DLBCL and AML cell lines. CA-4948 demonstrated moderate to high selectivity in a panel of 329 kinases as well as exhibited desirable ADME and PK profiles including good oral bioavailability in mice, rat, and dog and showed >90% tumor growth inhibition in relevant tumor models with excellent correlation with in vivo PD modulation. 了解更多 -
PF-06882961
Catalog No. A22492 GLP-1R agonistPF-06882961 is a potent, orally bioavailable agonist of the glucagon-like peptide-1 receptor agonist (GLP-1R) 了解更多 -
Vodobatinib
Catalog No. A22504 Vodobatinib, also known as K-0706, is a novel 3rd generation (3G) TKI effective against wild-type and mutated BCR-ABL1 with limited off-target activity. 了解更多 -
MC-Gly-Gly-Phe
Catalog No. A22546 MC-Gly-Gly-Phe is a cleavable linker used for antibody-drug conjugates (ADC). 了解更多 -
Boc-Gly-Gly-Phe-Gly-OH
Catalog No. A22547 Boc-Gly-Gly-Phe-Gly-OH is a protease cleavable linker used for the antibody-drug conjugate (ADC). 了解更多 -
Boc-Dap-NE
Catalog No. A22548 Boc-Dap-NE is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 了解更多 -
Suberoyl bis-hydroxamic acid
Catalog No. A22581 HDAC1 and HDAC3 inhibitorSuberoyl bis-hydroxamic acid (Suberohydroxamic acid; SBHA) is a competitive and cell-permeable HDAC1 and HDAC3 inhibitor with ID50 values of 0.25 μM and 0.30 μM, respectively. 了解更多 -
DAPI dihydrochloride
Catalog No. A22602 fluorescent probeDAPI Dihydrochloride is a cell-permeable fluorescent probe used to stain DNA and chromosomes, with a preference for adenine and thymine rich DNA. 了解更多 -
Lidocaine N-ethyl bromide
Catalog No. A22615 blocker of fast Na+-dependent action potentials and voltage-dependentLidocaine N-ethyl bromide is a non-membrane-permeable blocker of fast Na+-dependent action potentials and voltage-dependent, non-inactivating Na+ conductance. 了解更多 -
Methoxy-PMS
Catalog No. A22647 active oxygen formation inducerMethoxy-PMS (1-Methoxy PMS), an active oxygen formation inducer, is stable electron-transport mediator between NAD(P)H and tetrazolium dyes. 了解更多 -
THPP-1
Catalog No. A22650 PDE10A inhibitorTHPP-1, a SGC chemical probe, is a potent and orally bioavailable phosphodiesterase 10A (PDE10A) inhibitor, with Ki values of 1 nM and 1.3 nM for human and rat PDE10A, respectively. THPP-1 has excellent pharmacokinetic properties in preclinical species. 了解更多 -
Lvguidingan
Catalog No. A22675 anticonvulsant/antiepileptic agentLvguidingan (Anticonvulsant 7903, 3,4-dichlorophenyl propenylisobutylamide) is an anticonvulsant/antiepileptic agent. Lvguidingan (Anticonvulsant 7903) is found to be able to increase the concentration of 5-HT and 5-HIAA in mice brain. 了解更多 -
Deferoxamine mesylate
Catalog No. A17761 iron chelatorDeferoxamine mesylate is an iron chelator that binds free iron in a stable complex, preventing it from engaging in chemical reactions. 了解更多
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