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产品 351 到 400 共 2783个

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  1. Succinic anhydride

    Catalog No. A20536
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    nonclaevable ADC linker
    Succinic anhydride is a cyclic anhydride and a nonclaevable ADC linker extracted from patent WO2009064913A1. Succinic anhydride can react with compound 4 of the patent to link the prodrug to an amine or hydroxy 1 group of a targeting polypeptide. 了解更多
  2. Docosatrienoic Acid

    Catalog No. A20529
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    Docosatrienoic acid is a rare ??-3 fatty acid; inhibits LTB4 binding to pig neutrophil membranes with an Ki of 5 μM. 了解更多
  3. FAAH-IN-2

    Catalog No. A20528
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    FAAH inhibitor
    FAAH-IN-2 (O-Desmorpholinopropyl Gefitinib) is a potent FAAH(fatty acid amide hydrolase) inhibitor extracted from Patent WO/2008/100977A2. 了解更多
  4. Ecteinascidin 770

    Catalog No. A20525
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    Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC50 of 4.83 nM. 了解更多
  5. O-Acetylserine

    Catalog No. A20524
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    O-Acetylserine (O-Acetyl-L-serine) is an intermediate in the biosynthesis of the amino acid cysteine in bacteria and plants. 了解更多
  6. SDMA

    Catalog No. A20518
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    NO inhibitor
    SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity. 了解更多
  7. UKI-1

    Catalog No. A20516
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    uPA system inhibitor
    UKI-1 is a novel synthetic inhibitor of the urokinase-type plasminogen activator system. 了解更多
  8. 4-Acetamidobutanoic acid

    Catalog No. A20514
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    4-Acetamidobutanoic acid (N-acetyl GABA) is a γ-aminobutyric acid (GABA) derivative. 了解更多
  9. ICI 153110

    Catalog No. A20513
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    phosphodiesterase inhibitor
    ICI 153110 is an orally active phosphodiesterase inhibitor with both vasodilating and inotropic properties which is designed for the treatment of congestive cardiac failure. 了解更多
  10. 2-(Methylamino)-1H-purin-6(7H)-one

    Catalog No. A20511
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    2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids. 了解更多
  11. L-DABA

    Catalog No. A20506
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    GABA transaminase inhibitor
    L-DABA (L-2,4-Diaminobutyric acid) is a week GABA transaminase inhibitor with an IC50 of larger than 500 μM; exhibits antitumor activity in vivo and in vitro. 了解更多
  12. Mivotilate

    Catalog No. A20504
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    AhR activator
    Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent. 了解更多
  13. Coenzyme Q9

    Catalog No. A20501
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    Coenzyme Q9, a nine isoprenyl group-containing member of the ubiquinone family, is a normal constituent of human plasma. 了解更多
  14. BI 689648

    Catalog No. A20499
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    aldosterone synthase inhibitor
    BI 689648 is a novel, highly selective aldosterone synthase inhibitor which can inhibit CYP11B1 and CYP11B2 with IC50s of 310 and 2.1 nM, respectively. 了解更多
  15. PCO371

    Catalog No. A20493
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    PTHR1 agonist
    PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor. 了解更多
  16. Oxaquin

    Catalog No. A20486
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    Oxaquin (MCB-3837) is a water-soluble, injectable prodrug that is rapidly converted to the active sub-stance MCB3681 in vivo following intravenous (i.v.) administration, active against Gram-positive bacterial species. Oxaquin (MCB-3837) itself has no antimicrobial effects. 了解更多
  17. Agmatine sulfate

    Catalog No. A20485
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    NO synthase inhibitor
    Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. 了解更多
  18. VUF10460

    Catalog No. A20484
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    histamine H4 receptor agonist
    VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46. 了解更多
  19. XEN723

    Catalog No. A20482
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    SCD1 inhibitor
    XEN723 is a novel and potent thiazolylimidazolidinone inhibitor of Stearoyl-CoA Desaturase (SCD1) with IC50s of 45 and 524 nM in mouse and HepG2 cell, respectively. 了解更多
  20. Cadazolid

    Catalog No. A20481
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    oxazolidinone antibiotic
    Cadazolid (ACT-179811) is a new oxazolidinone antibiotic with potent activity against Clostridium difficile. 了解更多
  21. GAL-021

    Catalog No. A20480
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    intravenous BKCa-channel blocker
    GAL-021 a new intravenous BKCa-channel blocker. 了解更多
  22. LSD1-IN-5

    Catalog No. A20479
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    LSD1 inhibitor
    LSD1-IN-5 (Compound 4e) is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 121 nM. LSD1-IN-5 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. 了解更多
  23. NIH-12848

    Catalog No. A20476
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    (PI5P4Kγ inhibitor
    NIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM. 了解更多
  24. ML-210

    Catalog No. A20475
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    inhibitor of glutathione peroxidase 4 (GPX4)
    ML-210??the most potent compound in the nitroisoxazole series?? is a selective covalent inhibitor of glutathione peroxidase 4 (GPX4) by binding the selenocysteine residue. 了解更多
  25. LSD1-IN-6

    Catalog No. A20474
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    LSD1 inhibitor
    LSD1-IN-6 (Compound 4m) is a potent and reversible inhibitor of lysine-specific demethylase 1 (LSD1), with an IC50 of 123 nM. LSD1-IN-6 increases dimethylated Lys4 of histone H3, shows no effect on expression of LSD1. 了解更多
  26. C-11

    Catalog No. A20470
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    tubulin inhibitor
    C-11 is a tubulin inhibitor and acts as a ADC cytotoxin, displays cytotoxicity for carcinoma cell lines. 了解更多
  27. TM5275 sodium

    Catalog No. A20462
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    plasminogen activator inhibitor
    TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 μM. 了解更多
  28. NS-638

    Catalog No. A20460
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    NS-638 is a small nonpeptide molecule with Ca2+-channel blocking properties. K+-stimulated intracellular Ca2+-elevation is blocked with an IC50 value of 3.4 μM. 了解更多
  29. BRCA1-IN-1

    Catalog No. A20459
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    BRCA1 inhibitor
    BRCA1-IN-1 is a novel small-molecule-like BRCA1 inhibitor with IC50 and Ki of 0.53 μM and 0.71 μM, respecrively. 了解更多
  30. Trifarotene

    Catalog No. A20458
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    RAR agonist
    Trifarotene (CD5789) is a retinoic acid receptor (RAR) agonist with Kdapp of 2, 15 and 500 nM for RARγ, RARβ and RARα, respectively. 了解更多
  31. CGP 25454A

    Catalog No. A20448
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    dopamine autoreceptor antagonist
    CGP 25454A is a novel and selective presynaptic dopamine autoreceptor antagonist. 了解更多
  32. Ralfinamide

    Catalog No. A20446
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    Na+ blocker
    Ralfinamide (FCE-26742A) is an orally available Na+ blocker derived from α-aminoamide, with function of suppressing pain. 了解更多
  33. JPH203

    Catalog No. A20445
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    LAT-1 inhibitor
    JPH203 is a potent and selective L-type amino acid transporter 1 (LAT-1) inhibitor. 了解更多
  34. beta-L-D4A

    Catalog No. A20444
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    HIV-1 reverse transcriptase inhibitor
    beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor. 了解更多
  35. ZL006

    Catalog No. A20443
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    nNOS/PSD-95 interaction inhibitor
    ZL006 is a potent inhibitor of nNOS/PSD-95 interaction, and inhibits NMDA receptor-mediated NO synthesis. 了解更多
  36. IC87201

    Catalog No. A20438
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    PSD95-nNOS interactions inhibitor
    IC87201, an inhibitor of PSD95-nNOS protein-protein interactions, suppresses NMDAR-dependent NO and cGMP formation. 了解更多
  37. TPI-1

    Catalog No. A20423
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    SHP-1 inhibitor
    TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor; inhibits recombinant SHP-1 with an IC50 of 40 nM. 了解更多
  38. GCN2-IN-1

    Catalog No. A20412
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    GCN2 inhibitor
    GCN2-IN-1 (A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC50 of <0.3 μM in the enzyme assay and an IC50 of 0.3-3 μM in the cell assay. 了解更多
  39. Chymase-IN-1

    Catalog No. A20404
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    chymase inhibitor
    Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. 了解更多
  40. PQR620

    Catalog No. A20400
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    mTORC1/2 inhibitor
    PQR620 is a novel potent and selective brain penetrant inhibitor of mTORC1/2. 了解更多
  41. Revizinone

    Catalog No. A20398
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    PDE inhibitor
    Revizinone is a novel selective phosphodiesterase (PDE) inhibitor with IC50 values on this enzyme to 0.036 microM. 了解更多
  42. PD 117519

    Catalog No. A20388
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    A2A adenosine agonist
    PD 117519 (CI947) is an A2A adenosine agonist which has shown oral antihypertensive activity in pharmacological animal models. 了解更多
  43. Adenosine antagonist-1

    Catalog No. A20383
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    AA3R antagonist
    Adenosine antagonist-1 is an adenosine A3 receptor (AA3R) antagonist. 了解更多
  44. MPT0B392

    Catalog No. A20378
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    microtubule-depolymerizing agent
    MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line. 了解更多
  45. Naminidil

    Catalog No. A20375
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    cyanoguanidine KATP opener
    Naminidil is a cyanoguanidine KATP opener. 了解更多
  46. Fenobam

    Catalog No. A20372
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    mGluR5 antagonist
    Fenobam is a selective, orally active, and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). 了解更多
  47. TAK-243

    Catalog No. A20369
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    UAE (UBA1) inhibitor
    TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor (IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. 了解更多
  48. Bromobimane

    Catalog No. A20366
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    Bromobimane is essentially nonfluorescent and converts into fluorescent products when reacts with small thiols. 了解更多
  49. TBHQ

    Catalog No. A20358
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    Nrf2 activator
    TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2. 了解更多
  50. 9-Propenyladenine

    Catalog No. A20357
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    9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors, which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV. 了解更多

产品 351 到 400 共 2783个

每页
页面:
  1. 6
  2. 7
  3. 8
  4. 9
  5. 10

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