“alpha ergocryptine”的搜索结果
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PRMT5 inhibitor
DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity.
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10-atom linker PROTAC
SJFδ is a 10-atom linker PROTAC. SJFδ degrades p38δ with a DC50 of 46.17?nM, but does not degrade p38α, p38β, or p38γ.
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PKCδ inhibitor
BJE6-106 (B106) is a potent, selective 3rd generation PKCδ inhibitor with an IC50 of 0.05 μM and targets selectivity over classical PKC isozyme PKCα (IC50=50 μM).
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LPA5 antagonist
AS2717638 is an oral active and selective lysophosphatidic acid receptor 5 (LPA5) antagonist, with an IC50 of 38 nM for hLPA5. AS2717638 also significantly improves PGE2-, PGF2α-, and AMPA-induced allodynia.
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neuropeptide Y1 receptor antagonist
BMS-193885 is a potent, competitive neuropeptide (NPY) Y1 antagonist (Ki = 3.3 nM, IC50 = 5.9 nM) that displays > 47, > 100, > 160, > 160 and > 160-fold selectivity over ??1, α1, Y2, Y4 and Y5 receptors respectively.
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PP2A activator
SMAP-2 (DT-1154) is an orally bioavailable phosphatase 2A (PP2A) activator which binds to the PP2A Aα scaffold subunit to drive conformational changes in PP2A.
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ABHD6 inhibitor
KT203 is a potent and selective inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.31 nM in Neuro2A cells.
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ABHD6 inhibitor
KT182 is a potent and selective inhibitor of α/β-hydrolase domain containing 6 (ABHD6), with an IC50 of 0.24 nM in Neuro2A cells.
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CDK9 inhibitor
MC180295 is a highly selective CDK9 inhibitor (IC50 = 5 nM). MC180295 also inhibits GSK-3α and GSK-3β. MC180295 ((rel)-MC180295) has potent anti-tumor effect.
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Santonin is an Anthelmintic isolated from the dried unexpanded flower heads of Artemisia maritima and other species of Artemisia found principally in Russian and Chinese Turkestan and the Southern Ural region.
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α-amino acid
L-Citrulline is an amino acid derived from ornithine in the catabolism of proline or glutamine and glutamate, or from l-arginine via arginine-citrulline pathway.
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Glucagon is a peptide hormone, produced by alpha cells of the pancreas. It works to raise the concentration of glucose in the bloodstream. Its effect is opposite that of insulin, which lowers the glucose.
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Ergoloid Mesylates, also known as dihydroergotoxine mesylate, is a mixture of three dihydrogenated ergot alkaloids (dihydroergocristine, dihydroergocornine, and alpha- and beta-dihydroergocryptine). Ergoloid mesylates is used as a treatment for dementia and Alzheimer disease.
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Antibiotic
Sulbenicillin disodium is a semisynthetic penicillin-type antibiotic.
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Antiarthritic
Actarit is a drug that has been shown to suppress disease activity of rheumatoid arthritis (RA). Actarit reduces spontaneous tumor necrosis factor-alpha and interleukin 1beta secretion by primary synovial cells of patients with RA.
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Vitamin K1 a fat-soluble, naturally occurring vitamin required for blood coagulation and bone and vascular metabolism.
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Dopamine receptor antagonist
Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.
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Amitraz, also known as Mitaban and Taktic, is an alpha-adrenergic receptor agonist and MAO inhibitor used as an insecticide in prevention of flea and tick infections. It prevents prostaglandin synthesis and may inhibit beta-cell insulin release.
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Abiraterone metabolite 1是abiraterone的5β还原代谢产物。类固醇药物abiraterone可抑制CYP17A1,阻断雄激素的合成并延长前列腺癌的生存期。
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α1β1 抑制剂
Obtustatin是高度有效的整联蛋白α1β1抑制剂(α1β1与IV型胶原的结合的IC 50 = 0.8 nM)。与α2β1,βIIbβ3,αvβ3,α4β1,β5β6,α9β1和α4β7相比,α1β1具有选择性。在鸡绒膜尿囊炎模型中抑制FGF2刺激的血管生成。在Lewis肺癌的协同小鼠模型中显示抗肿瘤功效;阻止人黑素瘤在裸鼠中的生长。
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α2β1 integrin 抑制剂
BTT-3033是α2β1整联蛋白抑制剂。
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Rev-Erbα 激动剂
GSK4112是选择性的Rev-erbα激动剂,EC50值为250 nM。GSK4112是小分子化学探针, 用于核血红素受体REV-erbα的细胞生物学研究。
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α1 adrenoreceptor 拮抗剂
Urapidil是一种α1肾上腺素受体拮抗剂和5-HT1A受体激动剂。
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α7 Positive Modulator
NS 1738是α7阳性变构调节剂。在卵母细胞实验中,正调节 α7nAChR,EC50 为 3.4 μM。
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α1A 拮抗剂
RS 17053 HCl是α1A受体拮抗剂,对α1A受体具有很高的亲和力(pKi和pA2估计为9.1-9.9),选择性比α1B和α1D亚型高30-100倍(pKi和pA2估计为7.7- 7.8)。
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PGC-1α 抑制剂
SR 18292是PGC-1α抑制剂。在T2D的饮食和遗传小鼠模型中,它可降低血糖,强烈提高肝胰岛素敏感性并改善葡萄糖稳态。
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Stromal Cell-Derived Factor-1 alpha Rat Recombinant (CXCL12)
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Stromal Cell-Derived Factor-1 Alpha Mouse Recombinant (CXCL12)
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Stromal Cell-Derived Factor-1 alpha (CXCL12), Mouse Recombinant, His Tag
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Stromal Cell-Derived Factor-1 Alpha Human Recombinant (CXCL12)
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Stromal Cell-Derived Factor-1 alpha Human Recombinant, His Tag
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Macrophage Inflammatory Protein-3 alpha Human Recombinant (CCL20)
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Macrophage Inflammatory Protein-1 Alpha Human Recombinant (CCL3), His Tag
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Macrophage Inflammatory Protein-1 Alpha Rat Recombinant (CCL3)
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Macrophage Inflammatory Protein-1 Alpha Mouse Recombinant (CCL3)
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Macrophage Inflammatory protein-3 alpha (CCL20) Human Recombinant, His Tag
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Macrophage Inflammatory Protein-3 alpha Mouse Recombinant (CCL20)
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Macrophage Inflammatory Protein-1 Alpha Human Recombinant (CCL3)
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Macrophage Inflammatory Protein-1 Alpha Mouse Recombinant (CCL3), His Tag
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GRO-Alpha Rat Recombinant (CXCL1)
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GRO-Alpha Human Recombinant (CXCL1)
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GRO-Gamma Rat Recombinant (CXCL3), CINC-2 alpha
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GRO-Alpha/MGSA Human Recombinant (CXCL1), His Tag
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Tumor Necrosis Factor-alpha Mouse Recombinant, Sf9
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Tumor Necrosis Factor-alpha Human Recombinant, Sf9
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Tumor Necrosis Factor-alpha Rat Recombinant, His Tag
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Tumor Necrosis Factor, Alpha-Induced Protein 8 Human Recombinant
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Tumor Necrosis Factor-Alpha Rhesus Macaque Recombinant
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Tumor Necrosis Factor-Alpha Human Recombinant, His Tag
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Tumor Necrosis Factor-Alpha Rat Recombinant
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