MK-0557 is a highly selective, orally available neuropeptide Y5 receptor antagonist with a Ki of 1.6 nM. 了解更多

Impurity F of Calcipotriol; Calcipotriol (MC 903; Calcipotriene) is a ligand of VDR-like receptors. 了解更多

MK-5046 is a novel BRS-3 agonist, binds to BRS-3 with high affinity (mouse Ki = 1.6 nM, human Ki = 25 nM). 了解更多

MK-0429 (L-000845704) is an orally active, potent, selective and nonpeptide αvβ3 integrin antagonist with an IC50 of 80 nM. 了解更多

Relebactam is a diazabicyclooctane inhibitor with activity against a wide spectrum of β-lactamases, including class A (extended-spectrum β-lactamases [ESBLs] and KPC) and class C (AmpC) enzymes. 了解更多

Lisinopril (MK-521) is angiotensin-converting enzyme inhibitor, used in treatment of hypertension, congestive heart failure, and heart attacks. 了解更多

MK-7246 is a potent and selective CRTH2 antagonist with a Ki of 2.5??0.5 nM. 了解更多

Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. 了解更多

Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist. 了解更多

Ertapenem sodium is a new long-acting 1-β-methyl carbapenem antibiotic with a broad antibacterial spectrum including common aerobic and anaerobic bacteria and organisms with extended-spectrum β-lactamases. 了解更多

Grazoprevir (MK-5172) is a selective inhibitor of Hepatitis C virus NS3/4a protease with broad activity across genotypes and resistant variants, with Kis of 0.01 nM (gt1b), 0.01 nM (gt1a), 0.08 nM (gt2a), 0.15 nM (gt2b), 0.90 nM (gt3a), respectively. 了解更多

Niraparib tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. 了解更多

Taranabant is a highly potent and selective cannabinoid 1 (CB1) receptor inverse agonist that inhibits the binding and functional activity of various agonists, with a binding Ki of 0.13 nM for the human CB1R in vitro. 了解更多

MK-2894 sodium salt is a highly potent and selective second generation EP4 antagonist. 了解更多

Montelukast (sodium) (MK0476) is a potent, selective CysLT1 receptor antagonist. 了解更多

Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 ?M. 了解更多

MK-8998 (compound 33) is a potent and selective inhibitor of the T-type calcium channel. 了解更多

MK8722 is a potent and systemic pan-AMPK activator. 了解更多

MKC3946 is a potent and soluble IRE1α inhibitor, used for cancer research. 了解更多

Simvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. 了解更多

CMK is a RSK2 kinase inhibitor which exhibits similar potency but less chemical stability compared with FMK. 了解更多

T56-LIMKi is a selective inhibitor of LIMK2; inhibits the growth of Panc-1 cells with an IC50 of 35.2 μM. 了解更多

SDZ-MKS 492 (MKS 492) is a selective type III isozyme inhibitor of cyclic nucleotide phosphodiesterase, effective in allergic bronchoconstriction and platelet activating factor (PAF) or LTB4-induced inflammatory reactions in animals. 了解更多

FMK 9a is an autophagin-1 inhibitor with IC50 values of 80 and 73 μM in FRET and LRA assay. 了解更多

Menaquinone-7 (Vitamin K2-7), belongs to a class of K2-vitamin homologs, is originally discovered as the anti-hemorrhagic factors. 了解更多

MK-8617 is an orally active pan-inhibitor of hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) with an IC50 of 1 nM for PHD2. 了解更多

MK-447 is a free radical scavenger, also a nonsteroidal antiinflammatory agent, and enhances the formation of the endoperoxide, PGH2, and other prostaglandins. 了解更多

MK-2 Inhibitor III (compound 16) is an orally active, selective, and ATP-competitive MAPKAP-K2 (MK-2) inhibitor with an IC50 of 0.85 nM. 了解更多

Pyrazinamide is an antimycobacterial compound that inhibits the growth of the human M. tuberculosis H37Rv strain. 了解更多

Tetrahydrofluoroene 52 is a potent and selective estrogen receptor β agonist. 了解更多

TPA 023 is a GABAA α2/α3 subtype-selective agonist, with Ki of 0.19-0.41 nM. 了解更多

PT2977 is HIF-2alpha inhibitor with an IC50 of 9 nM. 了解更多

R-10015, a broad-spectrum antiviral compound for HIV infection, acts as a potent and selective inhibitor of LIM domain kinase (LIMK) and binds to the ATP-binding pocket, with an IC50 of 38 nM for human LIMK1. 了解更多

MK-8719 is a highly potent and selective OGA inhibitor (EC50 = 52.7 nM) which is a Potential Treatment for Tauopathies. MK-8719 showed excellent CNS penetration that has been advanced to first-in-human phase I clinical trials. 了解更多

Methyldopa Sesquihydrate is a DOPA decarboxylase inhibitor and indirect α2-adrenergic receptor agonist used to treat hypertension. 了解更多

Sodium succinate dibasic is an inhibitor of multiple receptor tyrosine kinases. Sodium succinate dibasic is known to be a potent inhibitor of Met, Flt-1 (VEGFR1), Flk-1 (VEGFR2), Flt-3 (VEGFR3), Ron, and Tie-2. Sodium succinate dibasic has been observed to inhibit Met (c-Met)-driven tumor cell and non-c-Met driven tumor cell (HCT116 and MDA-MB-231) proliferation. This product has also been observed to effectively inhibit c-Met phosphorylation and its downstream signaling pathways in serum starved MKN45 cells, as well as inducing apoptosis in these cells. 了解更多

Penicillin G benzathine anhydrous is a semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine. 了解更多

Midodrine is an ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION. 了解更多

Midodrine hydrochloride is an ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. It improves clinical outcome of chronic hypotension. 了解更多

Decanedioic acid, a normal urinary acid, is found to be associated with carnitine-acylcarnitine translocase deficiency and medium chain acyl-CoA dehydrogenase deficiency. 了解更多

Fosfosal is a non-acetylated salicylic acid derivative that acts as an anti-inflammatory analgesic drug. 了解更多

Nicarbazin is an equimolar complex of 4,4'-Dinitrocarbanilide and 2-Hydroxy-4,6-dimethylpyrimidine. It is used as a coccidiostat for poultry. 了解更多

Tafluprost, also known as MK2452 and AFP-168, is a prostaglandin analogue used topically (as eye drops) to control the progression of glaucoma and in the management of ocular hypertension. 了解更多

MK-3903是有效的选择性AMPK激活剂（EC50 = 8 nM）。口服给药后，MK-3903在小鼠肝脏中表现出强大的靶标参与性，从而改善了小鼠的脂质代谢和胰岛素敏感性。 了解更多

Menaquinone-4是一种维生素K，用作止血剂，也是骨质疏松症疼痛的辅助疗法。 了解更多

Bevenopran，也称为CB-5945，ADL-5945，MK-2402，OpRA III，是一种外周选择性μ-和δ-阿片样物质受体拮抗剂。 了解更多

Elbasvir (MK-8742)是一种NS5A抑制剂，可预防丙型肝炎病毒RNA复制和病毒体组装。根据基因型，EC50的中值范围为0.2至3600 pmol/L。 了解更多

MK-8353 (SCH900353)是一种口服生物利用型，选择性和有效的ERK抑制剂，在体外抑制激活的ERK1和ERK2，IC50值分别为23.0 nM和8.8 nM（IMAP激酶测定），以及未激活的ERK2，具有IC50值 0.5 nM（MEK1-ERK2耦合测定）。 了解更多

Calcium/Calmodulin-Dependent Protein Kinase II Inhibitor 2 Human Recombinant 了解更多