“alpha ergocryptine”的搜索结果
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GABAA α5 receptor agonist
MRK-016 is a selective, orally bioavailable inverse agonist of GABAA α5 receptor, with an EC50 of 3 nM for GABAA α5, and Kis of 0.83, 0.85, 0.77?and 1.4?nM for human?GABAA?α1β3γ2, GABAA?α2β3γ2, GABAA?α3β3γ2, and GABAA?α5β3γ2, respectively; MRK-016 also readily penetrates the CNS.
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Topoisomerase I inhibitor
MAC glucuronide α-hydroxy lactone-linked SN-38 (Topoisomerase I inhibitor) is a stabilized lactone MAC glucuronide α-hydroxy lactone-linked SN-38 drug linker.
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aromatase inhibitor
Alpha-Naphthoflavone is a synthetic flavonoid, acts as a potent and competitive aromatase inhibitor with an IC50 and a Ki of 0.5 and 0.2 μM, respectively.
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ERRa degrader
PROTAC ERRalpha Degrader-2 comprises a MDM2 ligand binding group, a linker and an estrogen-related receptor alpha (ERRa) binding group. PROTAC ERRalpha Degrader-2 is an estrogen-related receptor alpha (ERRa) degrader.
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alpha-Tocopherol is one of the most abundant isoforms of vitamin E. alpha-Tocopherol is a biologically active liposoluble vitamin and potent antioxidant.
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Lipoic Acid, also known as R-(+)-alpha-Lipoic acid, is an organosulfur compound derived from octanoic acid. It is made in animals normally, and is essential for aerobic metabolism. It is also manufactured and is available as a dietary supplement in some countries where it is marketed as an antioxidant, and is available as a pharmaceutical drug in other countries.
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p53 抑制剂
Pifithrin-alpha是p53介导的细胞凋亡和p53依赖性基因转录(如细胞周期蛋白G,p21/waf1和mdm2表达)的可逆抑制剂。
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Androgen 拮抗剂
17 alpha-propionate是一种新型的局部和外周选择性雄激素拮抗剂。
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choline kinase α (ChoKα) inhibitor
EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1.
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estrogen ligand
Estrone-N-O-C1-amido (ERα ligand 1) is an Estrone-based estrogen ligand, which targets estrogen receptor α (ERα). Estrone-N-O-C1-amido (ERα ligand 1) binds to cIAP1 ligand Bestatin via a linker to form SNIPER.
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5α-Cholestan-3β-ol is a derivitized steroid compound, which is isolated from the testes of White Carneau pigeons.
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protease inhibitor
N-alpha-Tosyl-L-lysine chloromethyl ketone (TLCK), a trypsin like protease inhibitor, sensitizes HeLa cells to Fas-mediated cell death.
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GABA(A) receptor modulator
NS11394 is a potent and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors.
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PPAR alpha/gamma agonist
Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively.
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α2 adrenergic agonist
AGN 192836 is a potent and selective α2 adrenergic agonist with EC50s of 8.7, 41 and 6.6 nM for α2A, α2B and α2C receptor, respectively.
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D-α-Tocopherol acetate (D-Vitamin E acetate) can be hydrolyzed to d-alpha-tocopherol (VE) and absorbed in the small intestine.
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Alpha-Estradiol是一种内源性雌激素受体配体(ERα和ERβ受体的Ki值分别为0.2和1.2 nM)。
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The aglycone of glycyrrhizin
18α-Glycyrrhetinic acid是甘草中发现的一种生物活性三萜类化合物。它显示对11-hs D1(11-羟基类固醇脱氢酶1)的选择性抑制。
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Tumor Necrosis Factor-Alpha Human Recombinant
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Interleukin-1 alpha Rat Recombinant, His Tag
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Interleukin-1 alpha Mouse Recombinant, His Tag
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Interleukin-1 alpha Rhesus Macaque Recombinant
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Interleukin-1 alpha Mouse Recombinant
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Interleukin-1 alpha Human Recombinant, His Tag
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Interleukin-1 alpha Porcine Recombinant
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Interleukin-1 alpha Rat Recombinant
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Interleukin-1 alpha Human Recombinant
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Protein Kinase A regulatory subunit-1 alpha Human Recombinant
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Inhibin-Alpha A Chain Human Recombinant
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Heat shock protein HSP 90-alpha, Mouse Anti Human
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CCAAT/enhancer binding protein CEBP Alpha Human Recombinant
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Gliadin Alpha Wheat Recombinant
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Heat Shock Protein-90 Alpha Human Recombinant
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PI3Kα 抑制剂
PI3K-alpha inhibitor 1 是从专利US/20120088764A1中提取的PI3Kα抑制剂,化合物243,IC50 <0.1uM,PI3Kα抑制剂1还抑制HDAC(0.1uM≤IC50≤1uM)。
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Cimigenol-3-O-alpha-L-阿拉伯糖苷是从Cimicifuga foetida L.干燥的根茎中提取的。
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alpha-hederin一种从常春藤提取的皂苷。
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alpha-Hederin提取自海葵银莲花。
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α-淀粉样前体蛋白调节剂是细胞可渗透的苯并内酰胺衍生的PKC激活剂(PKCα的Ki = 11.9 nM),即使在人类原纤维中为100 nM时,也能有效增强淀粉样前体蛋白(APP)的非淀粉样生成性α-加工。
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choline kinase α (CHKα) inhibitor
MN58b is a selective choline kinase α (CHKα) inhibitor, and results in inhibition of phosphocholine synthesis.
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endogenous estrogen-related receptor α (ERRα) agonist
Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist.
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α4β1/α4β7 integrin antagonist
Zaurategrast ethyl ester (CDP323), the ethyl ester prodrug of CT7758, is a α4β1/α4β7 integrin antagonist used for the treatment of inflammatory and autoimmune disorders.
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alpha-glucosidase/alpha-1,6-glucosidase inhibitor
N-Nonyldeoxynojirimycin (NN-DNJ) is a potent inhibitor of alpha-glucosidase and alpha-1,6-glucosidase (IC50s, 0.42, 8.4 μM, respectively), inhibits glycogen breakdown.
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HIF-2α agonist
M1001 is a weak agonist of HIF-2α, directly binds to the HIF-2α PAS-B domain, with a Kd of 667 nM. M1001 enhances the stabilities of HIF-2α-ARNT complex.
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Pozanicline (ABT-089) selectively activate neuronal nicotinic acetylcholine receptor (nAChR) subtypes, is a novel cholinergic agent that is a partial agonist at α4β2* nAChRs (Ki=16 nM) and shows high selectivity for α6β2* and α4α5β2 nAChR subtypes, the binding affinity (Ki, rat) for Pozanicline to [3H] cytisine sites is 16.7 nM.
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α7 nAChR-positive allosteric modulator
CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs.
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adrenergic receptor inhibitor
Asenapine(Org 5222) inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
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prostaglandin F2α (PGF2α) analogue
(+)-Cloprostenol is a prostaglandin F2α (PGF2α) analogue, and shows selective agonistic activity at the prostaglandin receptor.
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α2-adrenoceptor agonist
Medetomidine(Domtor) is a potent, highly selective α2-adrenoceptor agonist (Ki values are 1.08 and 1750 nM for α2- and α1-adrenoceptors respectively).
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α2-adrenergic receptor angatonist
OPC-28326 is a selective peripheral vasodilator and an angatonist of α2-adrenergic receptor, with Ki of 2040, 285, and 55?nM for α2A-, α2B- and α2C-adrenoceptors, respectively.
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GABAA α2/α3 agonist
TPA 023 is a GABAA α2/α3 subtype-selective agonist, with Ki of 0.19-0.41 nM.
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