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(S)-(+)-Rolipram
Catalog No. A10816 PDE4 inhibitor(S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor, with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells. 了解更多 -
Dexrazoxane
Catalog No. A17714 topoisomerase IIα inhibitorDexrazoxane is an intracellular iron chelator and an inhibitor of topoisomerase IIα. 了解更多 -
CFI-402257
Catalog No. A12037 TTK inhibitorCFI-402257, a pyrazolopyridin derivative, has been found to be a TTK inhibitor that could influence chromosome segregation and induce cell death so that is significant in anticancer studies. 了解更多 -
9-Phenanthrol
Catalog No. A17570 TRPM4 blockerSelective TRPM4 blocker (IC50 = 20 μM in HEK293 cells). Exhibits no effect on CFTR or TRPM5 (at 0.25 and 1 mM respectively). Abolishes arrhythmias induced by hypoxia in a mouse heart model. 了解更多 -
Hydroxystilbamidine bis(methanesulfonate)
Catalog No. A22017 cellular ribonucleases inhibitorHydroxystilbamidine bis(methanesulfonate), a dye capable of binding to both DNA and RNA, has been found to be a powerful inhibitor of cellular ribonucleases. 了解更多 -
Helioxanthin derivative 5-4-2
Catalog No. A20885 Helioxanthin derivative 5-4-2 is an analogue of helioxanthin, exhibites significant in vitro anti-HBV activity with EC50 of 0.08 uM in HepG2.2.15 cells. 了解更多 -
(E)-[6]-Dehydroparadol
Catalog No. A20817 (E)-[6]-Dehydroparadol, extracted from patent US 9272994, compound M15, shows growth inhibition and induction of apoptosis against human cancer cells with IC50 values of 43.02 μM in HCT-116 cell and 41.59 μM in H-1299 cell, respectively. 了解更多 -
Solabegron
Catalog No. A20778 β3-adrenergic receptor agonistSolabegron (GW 427353) is a selective β3-adrenergic receptor agonist, stimulating cAMP accumulation in Chinese hamster ovary cells expressing the human β3-AR, with an EC50 value of 22 nM. 了解更多 -
WAY-204688
Catalog No. A20757 NF-κB inhibitorWAY-204688 is an estrogen receptor (ER-α) selective, orally active inhibitor of NF-κB transcriptional activity with an IC50 of 122?±?30 nM for NF-κB-luciferase (NF-κB-luc) in HAECT-1 cells. 了解更多 -
Duocarmycin MA
Catalog No. A20738 antibody drug conjugates (ADCs) toxinDuocarmycin MA is an antibody drug conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-drug resistant cell lines. 了解更多 -
NSC23005 sodium
Catalog No. A20665 p18 inhibitorNSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. 了解更多 -
JNJ-18038683
Catalog No. A20659 5-HT7 receptor antagonistJNJ-18038683 is a 5-Hydroxytryptamine Type 7 (5-HT7) receptor antagonist, with pKis of 8.19, 8.20 for rat and human 5-HT7 in HEK293 cells, respectively. 了解更多 -
Saroglitazar
Catalog No. A20636 PPAR agonistSaroglitazar is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively. 了解更多 -
3-Bromopyruvic acid
Catalog No. A20605 hexokinase II inhibitor3-Bromopyruvic acid is a hexokinase II inhibitor, is an effective antitumor agent on the hepatoma cells. 了解更多 -
NI-42
Catalog No. A20599 BRD inhibitorNI-42 (compound 13-d), a structurally orthogonal chemical probe for the BRPFs, is a biased, potent inhibitor of the BRD of the BRPFs (IC50s of BRPF1/2/3=7.9/48/260 nM; Kds of BRPF1/2/3=40/210/940 nM) with excellent selectivity over nonclass IV BRD proteins. 了解更多 -
JQ-1 (carboxylic acid)
Catalog No. A20579 BRD4 inhibitorJQ-1 carboxylic acid is a highly potent, selective and cell-permeable BRD4 inhibitor with IC50s of 77 nM and 33 nM for BRD4(1) and BRD4(2), respectively. 了解更多 -
Ecteinascidin 770
Catalog No. A20525 Ecteinascidin 770 (ET-770) is a 1,2,3,4-tetrahydroisoquinoline alkaloid with potent anti-cancer activities; inhibits U373MG cells with an IC50 of 4.83 nM. 了解更多 -
Fumarate hydratase-IN-1
Catalog No. A20471 fumarate hydratase inhibitorFumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM. 了解更多 -
BRCA1-IN-2
Catalog No. A20464 PPI inhibitorBRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions. 了解更多 -
mPGES1-IN-3
Catalog No. A20454 mPGES-1 inhibitormPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM). 了解更多 -
Urolithin A
Catalog No. A20426 Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis. 了解更多 -
LB-60-OF61
Catalog No. A20409 NAMPT inhibitorLB-60-OF61 is a NAMPT inhibitor and is a cytotoxic compound with a selectivity towards MYC overexpressing cell lines. 了解更多 -
Chymase-IN-1
Catalog No. A20404 chymase inhibitorChymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM. 了解更多 -
Biotin-VAD-FMK
Catalog No. A20384 caspase inhibitorBiotin-VAD-FMK is a cell permeable, irreversible biotin-labeled caspase inhibitor, used to identify active caspases in cell lysates. 了解更多
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