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CCG215022是有效的GRK2和GRK5抑制剂。CCG215022对GRK2和GRK5均表现出纳摩尔IC50值,对其他紧密相关的激酶(如GRK1和PKA)具有良好的选择性。
In vitro | DMSO | 89 mg/mL (178.18 mM) | |
Water | Insoluble | ||
Ethanol | Insoluble | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 20.02 mL | 100.1 mL | 200.2 mL |
0.5 mM | 4 mL | 20.02 mL | 40.04 mL |
1 mM | 2 mL | 10.01 mL | 20.02 mL |
5 mM | 0.4 mL | 2 mL | 4 mL |
*The above data is based on the productmolecular weight 499.51. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
目录号 | A16189 |
---|---|
作用机制 | Inhibitor (抑制剂) |
M. Wt | 499.51 |
Formula | C26H22FN7O3 |
Purity | >99% |
Storage | Store lyophilized at -20ºC, keep desiccated. |
CAS No. | 1813527-81-9 |
Synonyms | CCG 215022, CCG-215022 |
SMILES | O=C(C1=C(F)C=CC(C2C(C(NC3=CC=C(NN=C4)C4=C3)=O)=C(C)NC(N2)=O)=C1)NCC5=NC=CC=C5 |
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