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Cell Metabolism

产品 51 到 100 共 394个

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  1. BAY 73-6691 racemate
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    BAY 73-6691 racemate

    Catalog No. A21745
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    PDE9 inhibitor
    BAY 73-6691 racemate is a phosphodiesterase 9 inhibitor extracted from patent WO 2017070293 A1. 了解更多
  2. VP3.15 dihydrobromide
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    VP3.15 dihydrobromide

    Catalog No. A21789
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    PDE7/GSK3 inhibitor
    VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多
  3. IBMX
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    IBMX

    Catalog No. A21847
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    PDE inhibitor
    IBMX is a broad-spectrum phosphodiesterase (PDE) inhibitor, with IC50s of 6.5, 26.3 and 31.7 μM for PDE3, PDE4 and PDE5, respectively. 了解更多
  4. Olprinone
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    Olprinone

    Catalog No. A21869
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    PDE3 inhibitor
    Olprinone(Loprinone) is a selective phosphodiesterase 3 (PDE3) inhibitor. 了解更多
  5. TP-10
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    TP-10

    Catalog No. A21935
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    PDE10A inhibitor
    TP-10 is a PDE10A inhibitor with IC50 of 0.8 nM. 了解更多
  6. ITI214 free base
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    ITI214 free base

    Catalog No. A21947
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    picomolar PDE1 inhibitor
    ITI-214 (free base) is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). 了解更多
  7. Deltasonamide 2
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    Deltasonamide 2

    Catalog No. A21970
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    PDEδ inhibitor
    Deltasonamide 2 is a competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. 了解更多
  8. Deltasonamide 2 (TFA)
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    Deltasonamide 2 (TFA)

    Catalog No. A21979
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    PDEδ inhibitor
    Deltasonamide 2 TFA is competitive, high affinity PDEδ inhibitor with a Kd of ~385 pM. 了解更多
  9. Cilostazol
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    Cilostazol

    Catalog No. A10217
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    PDE3 抑制剂
    Cilostazol是3型磷酸二酯酶（PDE3）的选择性抑制剂，IC50为0.2 μM，其治疗重点是cAMP。 了解更多
  10. Rolipram
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    Rolipram

    Catalog No. A10805
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    PDE4 抑制剂
    Rolipram是一种PDE4抑制剂，IC50 = 2.0μM。 了解更多
  11. Icariin
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    Icariin

    Catalog No. A10464
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    PDE5 抑制剂
    Icariin对抑制PDE5A1、PDE5A2和PDE5A3的所有三种PDE5A亚型均有抑制作用，IC50值分别为1.0、0.75和1.1 μM。 了解更多
  12. Pimobendan (Vetmedin)
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    Pimobendan (Vetmedin)

    Catalog No. A10733
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    PDE 抑制剂
    Pimobendan (Vetmedin)是一种钙增敏剂，具有正性肌力和血管舒张作用。它也是磷酸二酯酶III（PDE3）的选择性抑制剂。 了解更多
  13. GSK256066
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    GSK256066

    Catalog No. A11073
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    PDE 抑制剂
    GSK256066是PDE4的极高亲和力和选择性抑制剂，它以相等的亲和力抑制PDE4亚型A-D，并具有很高的HARBS（高亲和力利普兰结合位点）比率（> 17）。 了解更多
  14. PF-2545920
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    PF-2545920

    Catalog No. A11191
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    PDE10A 抑制剂
    PF-2545920是对PDE10A亚型具有选择性的磷酸二酯酶抑制剂。 了解更多
  15. Ibudilast (KC-404)
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    Ibudilast (KC-404)

    Catalog No. A11019
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    PDE 抑制剂
    Ibudilast (KC-404)是一种相对非选择性的phosphodiesterase抑制剂，具有抗炎和神经保护活性。 了解更多
  16. Cilomilast (SB-207499)
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    Cilomilast (SB-207499)

    Catalog No. A10216
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    PDE-4 抑制剂
    Cilomilast (SB-207499)可作为选择性磷酸二酯酶4抑制剂，具有抗炎作用。可针对与COPD相关的支气管收缩，粘液分泌过多和气道重塑。 了解更多
  17. Hesperetin
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    Hesperetin

    Catalog No. A10449
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    PDE4 抑制剂
    Hesperetin是一种选择性磷酸二酯酶(PDE)4抑制剂，存在于中药“陈皮”中。橙皮素是一种柑橘类黄酮，据报道可以降低血浆胆固醇。橙皮素降低Hep-G2细胞中ACAT-2 mRNA的转录，并以剂量依赖的方式降低ApoB蛋白的合成。它也是类癌的潜在疗法。 了解更多
  18. Luteolin
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    Luteolin

    Catalog No. A10541
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    PDE4 抑制剂
    Luteolin是PDE4抑制剂、磷酸二酯酶抑制剂和白细胞介素6抑制剂，影响木聚嗪/氯胺酮诱导的小鼠麻醉。Luteolin作为单胺转运蛋白激活剂，是少数证明具有这种性质的化学物质之一。 了解更多
  19. Apremilast (CC 10004)
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    Apremilast (CC 10004)

    Catalog No. A11289
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    PDE4 抑制剂
    Apremilast (CC 10004)是一种新型的PDE4抑制剂，可抑制人类风湿性滑膜细胞自发产生肿瘤坏死因子-α，并改善实验性关节炎。 了解更多
  20. Vardenafil
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    Vardenafil

    Catalog No. A10965
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    PDE-5 抑制剂
    Vardenafil是用于治疗勃起功能障碍的PDE5抑制剂。 了解更多
  21. Roflumilast
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    Roflumilast

    Catalog No. A10804
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    PDE 抑制剂
    Roflumilast可作为PDE-4酶的选择性长效抑制剂，无细胞试验中IC50为0.2-4.3 nM。 了解更多
  22. Bay 60-7550
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    Bay 60-7550

    Catalog No. A11326
    PDE-2 抑制剂
    Bay 60-7550是一种强效PDE2抑制剂，IC50值为2.0 nM(牛)和4.7 nM(人)。 了解更多
  23. Dipyridamole
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    Dipyridamole

    Catalog No. A10319
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    PDE 抑制剂
    Dipyridamole (Persantine)是一种磷酸二酯酶抑制剂，可阻止红细胞和血管内皮细胞摄取和代谢腺苷。 了解更多
  24. Milrinone (Primacor)
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    Milrinone (Primacor)

    Catalog No. A10592
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    PDE3 抑制剂
    Milrinone (Primacor)是一种有效的选择性磷酸二酯酶3抑制剂，IC50为0.42μM，可抑制FIII PDE。 了解更多
  25. Zardaverine
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    Zardaverine

    Catalog No. A12550
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    PDE 3/4 抑制剂
    Zardaverine是一种磷酸二酯酶抑制剂，对PDE3和4具有选择性（IC50值分别为0.5和0.8 uM）。 了解更多
  26. Avanafil
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    Avanafil

    Catalog No. A12619
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    PDE5 抑制剂
    Avanafil是用于治疗勃起功能障碍的PDE5抑制剂，IC50为5.2 nM，对PDE1，PDE6和PDE11活性较低。 了解更多
  27. Crisaborole (AN2728)
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    Crisaborole (AN2728)

    Catalog No. A12776
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    PDE4 抑制剂?
    AN2728是一种局部给药的含硼抗炎化合物，可抑制PDE4活性，从而抑制TNFalpha，IL-12，IL-23和其他细胞因子的释放。抑制PDE4的 IC50 值为0.49 μM。 了解更多
  28. PF-04447943
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    PF-04447943

    Catalog No. A13121
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    PDE9 抑制剂
    PF-04447943是一种有效的选择性脑渗透pde9抑制剂，在大鼠和小鼠的多种认知模型中增加海马突触可塑性的指标并改善认知功能。 了解更多
  29. Deltarasin HCl
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    Deltarasin HCl

    Catalog No. A13722
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    PDE-KRAS 抑制剂
    Deltarasin HCl是一种新型的抑制KRASPDEδ相互作用从而破坏致癌性KRAS信号的小分子。 了解更多
  30. HA130
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    HA130

    Catalog No. A15546
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    Autotaxin 抑制剂
    HA130是一种选择性的autotaxin (ATX)抑制剂，IC50为 28 nM。 了解更多
  31. PF-8380
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    PF-8380

    Catalog No. A11527
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    Autotaxin 抑制剂
    PF-8380是一种强效和特异的自动调节蛋白抑制剂，IC50值为2.8 nM。 了解更多
  32. Tadalafil
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    Tadalafil

    Catalog No. A10883
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    PDE5 抑制剂
    Tadalafil是一种PDE5抑制剂，IC50值为1.8 nM。 了解更多
  33. Sildenafil Mesylate
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    Sildenafil Mesylate

    Catalog No. A16142
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    PDE5 抑制剂
    Sildenafil Mesylate是西地那非的甲磺酸盐形式，西地那非是磷酸二酯酶5的抑制剂。 了解更多
  34. Udenafil
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    Udenafil

    Catalog No. A13291
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    PDE5 抑制剂
    Udenafil是一种PDE5抑制剂，用于泌尿科治疗勃起功能障碍。 了解更多
  35. Vesnarinone
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    Vesnarinone

    Catalog No. A13313
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    PDE3 抑制剂
    Vesnarinone是一种喹啉酮衍生物，其药效作用包括抑制磷酸二酯酶III（PDE3）活性，增加钙通量和减少钾通量。 了解更多
  36. BW-A78U
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    BW-A78U

    Catalog No. A17098
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    PDE4 抑制剂
    BW-A78U是PDE4抑制剂，IC50为3μM。 了解更多
  37. BAY 73-6691
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    BAY 73-6691

    Catalog No. A17024
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    PDE9 抑制剂
    BAY 73-6691是一种有效的选择性脑渗透性PDE9A抑制剂。 了解更多
  38. BRL-50481
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    BRL-50481

    Catalog No. A17008
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    PDE7 抑制剂
    BRL-50481充当对PDE7亚型具有选择性的磷酸二酯酶抑制剂。 了解更多
  39. Roflumilast N-oxide
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    Roflumilast N-oxide

    Catalog No. A16984
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    PDE4 抑制剂
    Roflumilast N-oxide是罗氟司特的活性代谢产物。Roflumilast N-oxide是磷酸二酯酶4抑制剂。 了解更多
  40. Ademetionine
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    Ademetionine

    Catalog No. A17531
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    PDE4B inhibitor
    Ademetionine, also known as AdoMet; MSI-195; SAMe, S-adenosylmethionine, is a PDE4B inhibitor potentially for treatment of primary biliary cirrhosis and major depressive disorder. 了解更多
  41. Lodenafil
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    Lodenafil

    Catalog No. A18029
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    PDE5 inhibitor
    Lodenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor for the treatment of erectile dysfunction (ED). 了解更多
  42. Fosphenytoin disodium
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    Fosphenytoin disodium

    Catalog No. A18184
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    PDE3 inhibitor
    Fosphenytoin Sodium is the sodium salt form of fosphenytoin, a prodrug that is hydrolyzed to the anticonvulsant phenytoin. It is an PDE3 (phosphodiesterase 3) inhibitor. 了解更多
  43. CM-675
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    CM-675

    Catalog No. A18741
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    PDE5/HDAC-1 inhibitor
    CM-675 is a dual phosphodiesterase 5 (PDE5) and class I histone deacetylases-selective inhibitor, with IC50 values of 114 nM and 673 nM for PDE5 and HDAC1, respectively. CM-675 has potential to treat Alzheimer??s disease. 了解更多
  44. BPN14770
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    BPN14770

    Catalog No. A18663
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    PDE4D inhibitor
    BPN14770 is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor with IC50s of 7.8 nM and 7.4 nM for PDE4D7 and PDE4D3, respectively. 了解更多
  45. MT-3014
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    MT-3014

    Catalog No. A18580
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    PDE 10A inhibitor
    MT-3014 is a potent, highly selective and brain-penetrated phosphodiesterase 10A (PDE 10A) inhibitor, with IC50s of 0.062 nM and 0.09 nM for human PDE 10A and bovine PDE 10A, respectively. 了解更多
  46. PDE12-IN-3
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    PDE12-IN-3

    Catalog No. A18579
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    PDE12 inhibitor
    PDE12-IN-3 is a phosphodiesterase 12 (PDE12) inhibitor with a pXC50 of 7.68. Antiviral activity. 了解更多
  47. VP3.15
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    VP3.15

    Catalog No. A18538
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    dual PDE7/GSK-3 inhibitor
    VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多
  48. TPN171
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    TPN171

    Catalog No. A18464
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    PDE5 inhibitor
    TPN171 is potent PDE5 inhibitor with subnanomolar potency for PDE5 and good selectivity over PDE6. 了解更多
  49. PF-05085727
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    PF-05085727

    Catalog No. A20098
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    PDE2A inhibitor
    PF-05085727 is a potent, selective and brain penetrant Phosphodiesterase 2A (PDE2A) inhibitor with an IC50 of 2 nM. 了解更多
  50. R 80123
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    R 80123

    Catalog No. A21836
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    phosphodiesterase inhibitor
    R 80123 is the Z-isomer of R 79595, is also a highly selective phosphodiesterase inhibitor. 了解更多

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  1. Cytochrome P450 (29)
  2. PPAR (1)
  3. PDE (71)
  4. HSP (42)
  5. Hydroxylases (12)
  6. Factor Xa (16)
  7. MAO (30)
  8. DHFR (6)
  9. Dehydrogenases (19)
  10. Procollagen C-proteinase (1)
  11. Carbonic Anhydrase (12)
  12. FAAH (11)
  13. 15-PGDH (2)
  14. CETP (6)
  15. Ferroptosis (5)
  16. HMG-CoA Reductase (15)
  17. Isocitrate Dehydrogenase (IDH) (14)
  18. IDO (13)
  19. Lipase (9)
  20. Phospholipases (10)
  21. Lipoxygenase (11)
  22. NAMPT (5)
  23. GLUT (3)
  24. Antimetabolite (3)
  25. Lipid Metabolism (1)
  26. SREBP (2)
  27. LDL (1)
  28. Foxo1 (1)
  29. DGAT (6)
  30. Farnesyl Transferase (6)
  31. CRM1 (6)
  32. Thioredoxin (2)
  33. Decarboxylase (1)
  34. ACLY (2)
  35. Fatty acid synthase (FASN) (6)
  36. Lactate dehydrogenase A (LDHA) (1)
  37. PFKFB3 (3)
  38. Ribonucleotide Reductase (2)
  39. Acetyl-CoA Carboxylase (6)
  40. Glucosidase (3)
  41. Phosphatase (4)
靶点
  1. 5-lipoxygenase (1)
  2. Carbonic Anhydrase (6)
  3. Carbonic Anhydrase I (3)
  4. Carbonic Anhydrase II (3)
  5. Carbonic Anhydrase IV (2)
  6. Carbonic Anhydrase IX (2)
  7. CETP (4)
  8. COX (1)
  9. COX-1 (1)
  10. COX-2 (2)
  11. DNMT (1)
  12. FTase (4)
  13. HDAC1 (1)
  14. HMG-CoA Reductase (9)
  15. HSP90 (1)
  16. KDM1A (LSD1) (1)
  17. MAO-A (1)
  18. MAO-B (1)
  19. PDE4 (1)
  20. PDE5 (1)
  21. Src (1)
  22. TNF-α (1)
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