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￥ 0.00 Cell Metabolism
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SW033291
Catalog No. A15798 -
CKD-519
Catalog No. A18873 CETP inhibitorCKD-519 is a selective and potent cholesteryl ester transfer protein (CETP) inhibitor being developed for the treatment of dyslipidemia to raise high-density lipoprotein cholesterol. Single doses of CKD-519 up to 400 mg were well tolerated and showed potent inhibition of CETP activity. 了解更多 -
Anacetrapib (MK-0859)
Catalog No. A11084 CETP 抑制剂Anacetrapib (MK-0859)是一种有效的，选择性，可逆的rhCETP和突变CETP(C13S)抑制剂，IC50分别为7.9 nM和11.8 nM，提高HDL-C，降低LDL-C，不提高醛固酮和血压。 了解更多 -
JTT-705 (Dalcetrapib)
Catalog No. A11213 CETP 抑制剂JTT-705 (Dalcetrapib)是一种CETP抑制剂，抑制CETP是增加HDL-胆固醇并可能减少动脉粥样硬化的目标。 了解更多 -
Torcetrapib (CP-529414)
Catalog No. A11242 -
Evacetrapib (LY2484595)
Catalog No. A11397 CETP 抑制剂Evacetrapib (LY2484595)是一种强效选择性CETP抑制剂，IC50为5.5 nM，可在不增加醛固酮或血压的情况下升高HDL胆固醇。 了解更多 -
UAMC-3203 hydrochloride
Catalog No. A21683 Ferroptosis inhibitorUAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. 了解更多 -
Ferrostatin-1 (Fer-1)
Catalog No. A13247 ferroptosis 抑制剂Ferrostatin-1 (Fer-1)是一种有效的选择性铁锈病抑制剂，EC50为60 nM。 了解更多 -
Clinofibrate
Catalog No. A11184 HMG-CoA Reductase 抑制剂Clinofibrate是一种脂质清除剂，似乎可以改变脂质代谢，减少类固醇诱导的骨细胞内脂质堆积。它还可以有效降低血浆纤维蛋白原水平。抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)（羟甲基戊二酰辅酶A还原酶），IC50为0.47 mM。 了解更多 -
Rosuvastatin
Catalog No. A11122 -
2-Hydroxy atorvastatin calcium salt
Catalog No. A18971 HMG-CoA reductase inhibitor2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. 了解更多 -
Simvastatin
Catalog No. A10845 HMG-CoA reductase inhibitorSimvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. 了解更多 -
Fluvastatin sodium
Catalog No. A10403 HMG-CoA reductase inhibitorFluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. 了解更多 -
Fluvastatin
Catalog No. A21232 HMG-CoA reductase inhibitorFluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. 了解更多 -
Rosuvastatin calcium (Crestor)
Catalog No. A10810 HMG-CoA reductase 抑制剂Rosuvastatin calcium (Crestor)是他汀类药物中的一员，用于治疗高胆固醇及相关疾病，并预防心血管疾病。罗苏伐他汀是一种竞争性HMG-CoA reductase抑制剂，无细胞试验中IC50为11 nM。 了解更多 -
Pravastatin sodium
Catalog No. A11912 HMG-CoA reductase 抑制剂Pravastatin sodium是3-羟基-3-甲基辅酶A（HMG-CoA）还原酶的水溶性竞争性抑制剂。有效阻断体内胆固醇合成（Ki?1 nM）并显示出心脏保护特性。 了解更多 -
Atorvastatin calcium
Catalog No. A11800 HMG-CoA reductase 抑制剂Atorvastatin calcium (Lipitor)是HMG-CoA还原酶的抑制剂，可用作降低胆固醇的药物，可阻止胆固醇的产生。 了解更多 -
Pitavastatin calcium (Livalo)
Catalog No. A10737 HMG-CoA reductase 抑制剂Pitavastatin calcium (Livalo)是HMGCR（HMG-CoA还原酶）酶的竞争性抑制剂，可降低LDL胆固醇的合成。 了解更多 -
Lovastatin (Mevacor)
Catalog No. A11877 HMG-CoA reductase 抑制剂Lovastatin (Mevacor)是HMG-CoA还原酶的抑制剂，IC50为3.4 nM，用于降低胆固醇。 了解更多 -
Swertiamarin
Catalog No. A12128 -
Mevastatin
Catalog No. A13709 -
Atorvastatin
Catalog No. A13743 HMG-CoA reductase 抑制剂Atorvastatin是一种HMG-CoA还原酶抑制剂（IC50 = 154 nM），可有效治疗高胆固醇血症和某些血脂异常。 了解更多 -
Pitavastatin Lactone
Catalog No. A13896 -
Mutant IDH1 inhibitor
Catalog No. A21150 mutant IDH1 R132H inhibitorMutant IDH1 inhibitor is a potent mutant IDH1 R132H inhibitor with IC50 of < 72 nM. 了解更多 -
Mutant IDH1-IN-2
Catalog No. A21339 IDH inhibitorMutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay. 了解更多 -
Mutant IDH1-IN-1
Catalog No. A21359 mutant-selective IDH1 inhibitorMutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively. 了解更多 -
AGI-5198 (IDH-C35)
Catalog No. A12902 -
AG-120 (Ivosidenib)
Catalog No. A14386 -
Vorasidenib
Catalog No. A16908 IDH1 抑制剂Vorasidenib (AG-881)是一种有效且选择性的口服抑制剂，可抑制细胞质中异柠檬酸脱氢酶1型(IDH1，IDH1 [NADP+]可溶)和2型（IDH2异柠檬酸脱氢酶[NADP+]）的突变形式。线粒体中的线粒体，具有潜在的抗肿瘤活性。 了解更多 -
BAY-1436032
Catalog No. A17059 -
Olutasidenib (FT-2102)
Catalog No. A18789 IDH1 inhibitorOlutasidenib is a potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 for the treatment of acute myeloid leukemia. 了解更多 -
Mutant IDH1-IN-4
Catalog No. A19106 IDH1 inhibitorMutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ?? 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells. 了解更多 -
IDH1 Inhibitor 2
Catalog No. A18420 IDH1 inhibitorDH1 Inhibitor 2 is a potent IDH1 inhibitor via a direct covalent modification of His315, with an IC50 of 110 nM. 了解更多 -
Epacadostat (INCB024360)
Catalog No. A15554 IDO 抑制剂Epacadostat (INCB024360)是一种有效的选择性吲哚胺2,3-二加氧酶（IDO1）抑制剂，第2期的IC50为10 nM。 了解更多 -
IDO/TDO-IN-1
Catalog No. A18566 IDO/TDO dual inhibitorIDO/TDO-IN-1 is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively . 了解更多 -
GNF-PF-3777
Catalog No. A13507 hIDO2 inhibitorGNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM. 了解更多 -
IACS-8968 R-enantiomer
Catalog No. A21555 dual IDO/TDO inhibitorIACS-8968 (R-enantiomer) is the R-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 了解更多 -
IACS-8968 S-enantiomer
Catalog No. A21559 dual IDO/TDO inhibitorIACS-8968 (S-enantiomer) is the S-enantiomer of IACS-8968. IACS-8968 is a dual IDO and TDO inhibitor, with pIC50s of 6.43 for IDO and <5 for TDO, respectively. 了解更多
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- 分类
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- Cytochrome P450 (29)
- PPAR (1)
- PDE (71)
- HSP (42)
- Hydroxylases (12)
- Factor Xa (16)
- MAO (30)
- DHFR (6)
- Dehydrogenases (19)
- Procollagen C-proteinase (1)
- Carbonic Anhydrase (12)
- FAAH (11)
- 15-PGDH (2)
- CETP (6)
- Ferroptosis (5)
- HMG-CoA Reductase (15)
- Isocitrate Dehydrogenase (IDH) (14)
- IDO (13)
- Lipase (9)
- Phospholipases (10)
- Lipoxygenase (11)
- NAMPT (5)
- GLUT (3)
- Antimetabolite (3)
- Lipid Metabolism (1)
- SREBP (2)
- LDL (1)
- Foxo1 (1)
- DGAT (6)
- Farnesyl Transferase (6)
- CRM1 (6)
- Thioredoxin (2)
- Decarboxylase (1)
- ACLY (2)
- Fatty acid synthase (FASN) (6)
- Lactate dehydrogenase A (LDHA) (1)
- PFKFB3 (3)
- Ribonucleotide Reductase (2)
- Acetyl-CoA Carboxylase (6)
- Glucosidase (3)
- Phosphatase (4)
- 靶点
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- 5-lipoxygenase (1)
- Carbonic Anhydrase (6)
- Carbonic Anhydrase I (3)
- Carbonic Anhydrase II (3)
- Carbonic Anhydrase IV (2)
- Carbonic Anhydrase IX (2)
- CETP (4)
- COX (1)
- COX-1 (1)
- COX-2 (2)
- DNMT (1)
- FTase (4)
- HDAC1 (1)
- HMG-CoA Reductase (9)
- HSP90 (1)
- KDM1A (LSD1) (1)
- MAO-A (1)
- MAO-B (1)
- PDE4 (1)
- PDE5 (1)
- Src (1)
- TNF-α (1)
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