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￥ 0.00 Cell Metabolism
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URB597
Catalog No. A11049 -
PF-04457845
Catalog No. A15209 -
FAAH inhibitor 1
Catalog No. A21841 FAAH inhibitorFAAH inhibitor 1 (Benzothiazole analog 3) is a potent fatty acid amide hydrolase (FAAH) inhibitor with an IC50 of 18??8 nM. 了解更多 -
PF-3845
Catalog No. A11183 -
LY 2183240
Catalog No. A11960 FAAH 抑制剂LY 2183240既可作为内源性大麻素再摄取的有效抑制剂，IC50为270 pM，又可作为脂肪酸酰胺水解酶（FAAH）的抑制剂，IC50为12.4 nM，而脂肪酸酰胺水解酶是负责降解花生四烯酸的主要酶。 了解更多 -
JNJ 1661010
Catalog No. A12420 -
Glycyrrhetinic acid (Enoxolone)
Catalog No. A10353 -
SW033291
Catalog No. A15798 -
CKD-519
Catalog No. A18873 CETP inhibitorCKD-519 is a selective and potent cholesteryl ester transfer protein (CETP) inhibitor being developed for the treatment of dyslipidemia to raise high-density lipoprotein cholesterol. Single doses of CKD-519 up to 400 mg were well tolerated and showed potent inhibition of CETP activity. 了解更多 -
Anacetrapib (MK-0859)
Catalog No. A11084 CETP 抑制剂Anacetrapib (MK-0859)是一种有效的，选择性，可逆的rhCETP和突变CETP(C13S)抑制剂，IC50分别为7.9 nM和11.8 nM，提高HDL-C，降低LDL-C，不提高醛固酮和血压。 了解更多 -
JTT-705 (Dalcetrapib)
Catalog No. A11213 CETP 抑制剂JTT-705 (Dalcetrapib)是一种CETP抑制剂，抑制CETP是增加HDL-胆固醇并可能减少动脉粥样硬化的目标。 了解更多 -
Torcetrapib (CP-529414)
Catalog No. A11242 -
Evacetrapib (LY2484595)
Catalog No. A11397 CETP 抑制剂Evacetrapib (LY2484595)是一种强效选择性CETP抑制剂，IC50为5.5 nM，可在不增加醛固酮或血压的情况下升高HDL胆固醇。 了解更多 -
UAMC-3203 hydrochloride
Catalog No. A21683 Ferroptosis inhibitorUAMC-3203 hydrochloride is a potent and selective Ferroptosis inhibitor with an IC50 of 12 nM. 了解更多 -
Ferrostatin-1 (Fer-1)
Catalog No. A13247 ferroptosis 抑制剂Ferrostatin-1 (Fer-1)是一种有效的选择性铁锈病抑制剂，EC50为60 nM。 了解更多 -
Clinofibrate
Catalog No. A11184 HMG-CoA Reductase 抑制剂Clinofibrate是一种脂质清除剂，似乎可以改变脂质代谢，减少类固醇诱导的骨细胞内脂质堆积。它还可以有效降低血浆纤维蛋白原水平。抑制hydroxymethylglutaryl coenzyme A reductase (HMGCR)（羟甲基戊二酰辅酶A还原酶），IC50为0.47 mM。 了解更多 -
Rosuvastatin
Catalog No. A11122 -
2-Hydroxy atorvastatin calcium salt
Catalog No. A18971 HMG-CoA reductase inhibitor2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM. 了解更多 -
Simvastatin
Catalog No. A10845 HMG-CoA reductase inhibitorSimvastatin (MK 733) is a competitive inhibitor of HMG-CoA reductase with a Ki of 0.2 nM. 了解更多 -
Fluvastatin sodium
Catalog No. A10403 HMG-CoA reductase inhibitorFluvastatin sodium (XU 62320) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. 了解更多 -
Fluvastatin
Catalog No. A21232 HMG-CoA reductase inhibitorFluvastatin (XU 62-320 free acid) is a first fully synthetic, competitive HMG-CoA reductase inhibitor with an IC50 of 8 nM. 了解更多 -
Rosuvastatin calcium (Crestor)
Catalog No. A10810 HMG-CoA reductase 抑制剂Rosuvastatin calcium (Crestor)是他汀类药物中的一员，用于治疗高胆固醇及相关疾病，并预防心血管疾病。罗苏伐他汀是一种竞争性HMG-CoA reductase抑制剂，无细胞试验中IC50为11 nM。 了解更多 -
Pravastatin sodium
Catalog No. A11912 HMG-CoA reductase 抑制剂Pravastatin sodium是3-羟基-3-甲基辅酶A（HMG-CoA）还原酶的水溶性竞争性抑制剂。有效阻断体内胆固醇合成（Ki?1 nM）并显示出心脏保护特性。 了解更多 -
Atorvastatin calcium
Catalog No. A11800 HMG-CoA reductase 抑制剂Atorvastatin calcium (Lipitor)是HMG-CoA还原酶的抑制剂，可用作降低胆固醇的药物，可阻止胆固醇的产生。 了解更多 -
Pitavastatin calcium (Livalo)
Catalog No. A10737 HMG-CoA reductase 抑制剂Pitavastatin calcium (Livalo)是HMGCR（HMG-CoA还原酶）酶的竞争性抑制剂，可降低LDL胆固醇的合成。 了解更多 -
Lovastatin (Mevacor)
Catalog No. A11877 HMG-CoA reductase 抑制剂Lovastatin (Mevacor)是HMG-CoA还原酶的抑制剂，IC50为3.4 nM，用于降低胆固醇。 了解更多 -
Swertiamarin
Catalog No. A12128 -
Mevastatin
Catalog No. A13709 -
Atorvastatin
Catalog No. A13743 HMG-CoA reductase 抑制剂Atorvastatin是一种HMG-CoA还原酶抑制剂（IC50 = 154 nM），可有效治疗高胆固醇血症和某些血脂异常。 了解更多 -
Pitavastatin Lactone
Catalog No. A13896 -
DY 268
Catalog No. A16077 -
Cilofexor
Catalog No. A13143 -
Nidufexor
Catalog No. A12625 -
Fexaramine
Catalog No. A21771 FXR agonistFexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds. 了解更多 -
WAY-362450
Catalog No. A11186 FXR 激动剂WAY-362450是一种高效，选择性和口服可生物利用的法呢类X受体（FXR）激动剂（EC50：4 nM，eff = 149％）。 了解更多 -
Lithocholic acid
Catalog No. A12547 -
Obeticholic Acid
Catalog No. A13866 FXR 激动剂Obeticholic Acid是一种有效的选择性法呢类X受体（FXR）激动剂，EC50为99 nM。 了解更多 -
Px-104
Catalog No. A16999
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- 分类
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- Cytochrome P450 (59)
- PPAR (47)
- PDE (74)
- HSP (47)
- Hydroxylases (14)
- Factor Xa (17)
- MAO (30)
- DHFR (10)
- Dehydrogenases (27)
- Procollagen C-proteinase (1)
- Carbonic Anhydrase (12)
- LXR (13)
- FAAH (11)
- 15-PGDH (2)
- CETP (6)
- Ferroptosis (5)
- HMG-CoA Reductase (15)
- FXR (14)
- Isocitrate Dehydrogenase (IDH) (14)
- IDO (13)
- Retinoid Receptor (22)
- Lipase (12)
- Phospholipases (13)
- Lipoxygenase (13)
- AhR (6)
- NAMPT (9)
- GLUT (4)
- Antimetabolite (10)
- Lipid Metabolism (1)
- Neuronal Metabolism (1)
- SREBP (2)
- LDL (3)
- Foxo1 (2)
- DGAT (6)
- Farnesyl Transferase (6)
- CRM1 (7)
- Thioredoxin (2)
- Vitamin (31)
- Decarboxylase (3)
- ACLY (2)
- Fatty acid synthase (FASN) (7)
- Glucokinase (3)
- Lactate dehydrogenase A (LDHA) (1)
- Oxidative Phosphorylation (3)
- PFKFB3 (3)
- Ribonucleotide Reductase (2)
- Acetyl-CoA Carboxylase (6)
- Glucosidase (12)
- Phosphatase (6)
- 作用机制
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- Inhibitor (抑制剂) (394)
- Agonist (激动剂) (66)
- Antagonist (拮抗剂) (22)
- Activator (激活剂) (11)
- Modulator (调节剂) (2)
- Blocker (阻断剂) (2)
- Inducer (诱导剂) (5)
- Substrate (底物) (4)
- 靶点
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- 5-lipoxygenase (1)
- Carbonic Anhydrase (6)
- Carbonic Anhydrase I (3)
- Carbonic Anhydrase II (3)
- Carbonic Anhydrase IV (2)
- Carbonic Anhydrase IX (2)
- CETP (4)
- COX (1)
- COX-1 (1)
- COX-2 (2)
- DNMT (1)
- FTase (4)
- HDAC1 (1)
- HMG-CoA Reductase (9)
- HSP90 (1)
- KDM1A (LSD1) (1)
- MAO-A (1)
- MAO-B (1)
- PDE4 (1)
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- TNF-α (1)
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