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Cell Metabolism

产品 1 到 50 共 623个

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  1. RMC-4550
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    RMC-4550

    Catalog No. A18893
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    SHP2 inhibitor
    RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM. 了解更多
  2. SHP394
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    SHP394

    Catalog No. A18613
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    SHP2 inhibitor
    SHP394 is an orally efficacious protein tyrosine phosphatase SHP2 inhibitor with an IC50 of 23 nM. 了解更多
  3. SHP2 IN-1
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    SHP2 IN-1

    Catalog No. A19099
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    SHP2 (PTPN11) inhibitor
    SHP2 IN-1 (compound 13) is an allergic inhibitor of SHP2 (PTPN11), with an IC50 of 3 nM. 了解更多
  4. SHP099 hydrochloride
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    SHP099 hydrochloride

    Catalog No. A21762
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    SHP2 inhibitor
    SHP099 hydrochloride is a potent, selective and orally available SHP2 inhibitor with an IC50 of 70 nM. 了解更多
  5. SHP099
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    SHP099

    Catalog No. A20594
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    SHP2 inhibitor
    SHP099 is a potent, selective, orally available SHP2 inhibitor with an IC50 of 70 nM. 了解更多
  6. IACS-13909
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    IACS-13909

    Catalog No. A22159
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    SHP2 allosteric inhibitor
    IACS-13909 is a selective, potent and orally active SHP2 allosteric inhibitor with an IC50 of 15.7 nM and a Kd of 32 nM. 了解更多
  7. Acarbose
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    Acarbose

    Catalog No. A10029
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    Anti-Diabetic Agent
    Acarbose是一种肠道alpha-glucosidase抑制剂，用于治疗2型糖尿病以及某些国家的前驱糖尿病。 了解更多
  8. Miglitol (Glyset)
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    Miglitol (Glyset)

    Catalog No. A11678
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    Miglitol inhibits称为α-葡萄糖苷酶的糖苷水解酶。 它主要用于2型糖尿病，可通过阻止碳水化合物（例如二糖，寡糖和多糖）消化成可被人体吸收的单糖来建立更好的血糖控制。 了解更多
  9. Miglustat hydrochloride
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    Miglustat hydrochloride

    Catalog No. A12797
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    Miglustat hydrochloride是一种口服活性的α-葡萄糖苷酶Ⅰ和Ⅱ以及神经酰胺特异性糖基转移酶抑制剂。 了解更多
  10. Celgosivir
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    Celgosivir

    Catalog No. A13118
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    alpha-glucosidase I 抑制剂
    Celgosivir是一种用于潜在治疗HCV感染的α-葡萄糖苷酶I抑制剂。 了解更多
  11. Vitexin
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    Vitexin

    Catalog No. A12135
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    Vitexin在dpph漂白试验中表现出抗氧化活性(IC50 = 24.2uM)，并且还抑制碳水化合物水解酶α-葡萄糖苷酶的活性(IC50 = 244 uM)。 了解更多
  12. Afegostat D-tartrate
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    Afegostat D-tartrate

    Catalog No. A14385
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    Afegostat D-tartrate是用于治疗某些形式的高雪氏病的实验药物。该物质以酒石酸盐的形式使用。异黄酮（IFG）是一种酸性β-葡萄糖苷酶（GCase）活性位点抑制剂，可作为药理伴侣。 了解更多
  13. Deoxynojirimycin
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    Deoxynojirimycin

    Catalog No. A14383
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    glucosidase I/II 抑制剂
    Deoxynojirimycin是马耳他酶-葡糖淀粉酶（α-葡糖苷酶I和II）抑制剂。它干扰N-连接的糖基化。 了解更多
  14. 3-Butylidenephthalide
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    3-Butylidenephthalide

    Catalog No. A14633
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    3-Butylidenephthalide是一种α-葡萄糖苷酶抑制剂。 了解更多
  15. Licochalcone C
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    Licochalcone C

    Catalog No. A14848
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    Licochalcone C 能够抑制 α-葡萄糖苷酶 (α-glucosidase)，其对 α-葡萄糖苷酶和蛋白酪氨酸磷酸酶 1B 的 IC50 值分别为 <100 nM 和 92.43 μM。 了解更多
  16. Voglibose
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    Voglibose

    Catalog No. A14945
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    alpha-glucosidase 抑制剂
    Voglibose是缬氨酰胺的N取代衍生物，对α-葡萄糖苷酶具有出色的抑制活性，并且对高血糖症和由高血糖症引起的各种疾病具有抗药性。 了解更多
  17. Terphenyllin
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    Terphenyllin

    Catalog No. A18967
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    Terphenyllin is a naturally abundant p-terphenyl metabolite isolated from the coral derived fungus Aspergillus candidus, has signi?cant α-glucosidase inhibitory activity. 了解更多
  18. Afegostat
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    Afegostat

    Catalog No. A21137
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    Afegostat is a pharmacological chaperone, which specifically and reversibly binds acid-β-glucosidase (GCase) in the endoplasmic reticulum (ER) with high affinity. 了解更多
  19. ND-646
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    ND-646

    Catalog No. A20079
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    ACC inhibitor
    ND-646 is an orally bioavailable and steric inhibitor of acetyl-CoA carboxylase (ACC) with IC50s of 3.5 nM and 4.1 nM for recombinant hACC1 and hACC2, respectively. 了解更多
  20. TOFA
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    TOFA

    Catalog No. A12276
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    ACCA inhibitor
    TOFA (RMI14514;MDL14514) is an allosteric inhibitor of acetyl-CoA carboxylase-α (ACCA ). 了解更多
  21. Olumacostat glasaretil
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    Olumacostat glasaretil

    Catalog No. A20840
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    ACC inhibitor
    Olumacostat glasaretil is a small molecule inhibitor of acetyl coenzyme A carboxylase (ACC). 了解更多
  22. PF-05175157
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    PF-05175157

    Catalog No. A21460
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    ACC inhibitor
    PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively. 了解更多
  23. CP-640186 hydrochloride
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    CP-640186 hydrochloride

    Catalog No. A21808
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    ACC inhibitor
    CP-640186 hydrochloride is a potent and cell-permeable Acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively. 了解更多
  24. Firsocostat
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    Firsocostat

    Catalog No. A21000
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    ACC inhibitor
    Firsocostat (ND-630; GS-0976; NDI-010976) is an acetyl-CoA carboxylase (ACC) inhibitor; inhibits human ACC1 and ACC2 with IC50 values of 2.1 and 6.1 nM, respectively. 了解更多
  25. Triapine
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    Triapine

    Catalog No. A14306
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    Ribonucleotide reductase 抑制剂
    Triapine是一种有效的核糖核苷酸还原酶抑制剂，具有抑制DNA合成的广谱抗肿瘤活性。 了解更多
  26. Didox
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    Didox

    Catalog No. A16304
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    ribonucleotide reductase 抑制剂
    Didox是核糖核苷酸还原酶（RR）的强抑制剂，可通过阻止脱氧核糖核苷酸的产生来干扰DNA的合成和修复，并且数十年来已显示出抗肿瘤作用。 了解更多
  27. PFK15
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    PFK15

    Catalog No. A14287
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    PFKFB3 抑制剂
    PFK15是一种有效的选择性6-磷酸果糖-2-激酶（PFKFB3），IC50为20 nM。 了解更多
  28. PFK-158
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    PFK-158

    Catalog No. A14398
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    PFK-2/FBPase 抑制剂
    PFK-158是6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶（PFK-2/FBPase）同工型3（PFKFB3）的抑制剂，是3-(3-吡啶基)-1-[4-吡啶基]-2-丙烯-1-酮(3PO)，具有潜在的抗肿瘤活性。 了解更多
  29. 3PO
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    3PO

    Catalog No. A15932
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    PFKFB3 抑制剂
    3PO是PFKFB3（6-磷酸果糖-2-激酶/果糖-2,6-双磷酸酶）抑制剂。 了解更多
  30. Atovaquone
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    Atovaquone

    Catalog No. A13708
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    Atovaquone是一种抗原生动物线粒体电子传递抑制剂。 了解更多
  31. Imeglimin
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    Imeglimin

    Catalog No. A16282
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    oxidative phosphorylation blocker
    Imeglimin是一种氧化磷酸化阻滞剂，可抑制肝糖异生，增加肌肉葡萄糖摄取并恢复正常的胰岛素分泌。 了解更多
  32. Imeglimin hydrochloride
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    Imeglimin hydrochloride

    Catalog No. A16283
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    oxidative phosphorylation blocker
    Imeglimin hydrochloride是新型含四氢三嗪的口服降糖药中的第一个，即glimins。已证明它可作用于肝脏，肌肉和胰腺γ-细胞，以独特地靶向2型糖尿病的关键缺陷。 了解更多
  33. AZ-33
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    AZ-33

    Catalog No. A13341
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    LDHA 抑制剂
    AZ33是LDHA抑制剂。 了解更多
  34. GKA50
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    GKA50

    Catalog No. A12859
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    glucokinase activator
    GKA50是强力的葡萄糖激酶激活剂。 了解更多
  35. Piragliatin
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    Piragliatin

    Catalog No. A13528
    Glucokinase activator
    Piragliatin是一种新型的葡萄糖激酶激活剂，在2型糖尿病患者的吸收后状态和葡萄糖激发后均降低血浆葡萄糖。 了解更多
  36. AM-2394
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    AM-2394

    Catalog No. A16331
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    glucokinase activator
    AM-2394是结构独特的葡萄糖激酶激活剂(GKA)。AM-2394以60 nM的EC50激活葡萄糖激酶(GK)。 了解更多
  37. Orlistat
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    Orlistat

    Catalog No. A10676
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    Orlistat是一种一般的脂肪酶抑制剂，对人十二指肠液的PL的IC50为122 ng / ml。 了解更多
  38. C75
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    C75

    Catalog No. A14107
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    FASN 抑制剂
    C75是新型有效的脂肪酸合酶抑制剂（FAS），可作为研究代谢紊乱和癌症中脂肪酸合成的工具。 了解更多
  39. C-75 Trans
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    C-75 Trans

    Catalog No. A15331
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    FASN 抑制剂
    C 75是脂肪酸合酶（FAS）的抑制剂，可减少小鼠的食物摄入量和体重。 了解更多
  40. TVB-3166
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    TVB-3166

    Catalog No. A18763
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    FASN inhibitor
    TVB-3166 is an orally-available, reversible, potent, and selective FASN inhibitor, inducing apoptosis, inhibiting anchorage-independent cell growth under lipid-rich conditions, and inhibiting in-vivo xenograft tumor growth. 了解更多
  41. TVB-3664
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    TVB-3664

    Catalog No. A18829
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    FASN inhibitor
    TVB-3664 is an orally available, reversible, potent, selective and highly bioavailable fatty acid synthase (FASN) inhibitor, with IC50 values of 18 nM and 12 nM for human and mouse cell palmitate synthesis, respectively. TVB-3664 significantly reduces tubulin palmitoylation and mRNA expression. 了解更多
  42. FASN-IN-2
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    FASN-IN-2

    Catalog No. A13063
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    FASN inhibitor
    FASN-IN-2 is a Fatty Acid Synthase (FASN) inhibitor extracted from patent WO2012122391A1, compound 152, has an IC50 of 0.052 μM and an EC50 of 0.072 μM. 了解更多
  43. HS80
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    HS80

    Catalog No. A21615
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    FASN inhibitor
    HS-80 is an enantiomer of Fasnall, which is a selective fatty acid synthase (FASN) inhibitor. HS-80 is able to inhibit the incorporation of tritiated acetate into lipids with an IC50 of 7.13 μM. 了解更多
  44. BMS303141
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    BMS303141

    Catalog No. A13807
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    ATP-citrate lyase 抑制剂
    BMS303141是有效的ATP柠檬酸裂解酶（ACL）抑制剂。BMS303141以8μM的IC50抑制HepG2细胞中的脂质合成，并在鼠类高脂血症模型中降低血浆甘油三酸酯。 了解更多
  45. ETC-1002
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    ETC-1002

    Catalog No. A15815
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    ACL 抑制剂 and AMPK 激活剂
    ETC-1002是一种新颖的，一流的可以降低LDL-C的小分子；肝AMP激活的蛋白激酶（AMPK）的激活剂;对肝ATP-柠檬酸裂解酶也具有有效的抑制活性（IC50 = 29 uM）。 了解更多
  46. Benserazide HCl (Serazide)
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    Benserazide HCl (Serazide)

    Catalog No. A10125
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    Benserazide hydrochloride (Serazide)是L-芳族氨基酸脱羧酶的抑制剂。 了解更多
  47. Carbidopa
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    Carbidopa

    Catalog No. A10181
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    aromatic-L-amino-acid decarboxylase 抑制剂
    Carbidopa是一种芳香族-L-氨基酸脱羧酶抑制剂，这是一种在L-色氨酸生物合成5-羟色胺和L-DOPA生物合成多巴胺（DA）中重要的酶。 了解更多
  48. Eflornithine hydrochloride hydrate
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    Eflornithine hydrochloride hydrate

    Catalog No. A16174
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    Eflornithine hydrochloride是一种可有效治疗面部多毛症的药物。 了解更多
  49. Calcipotriol
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    Calcipotriol

    Catalog No. A11346
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    Calcipotriol是一种低钙的维生素D受体（VDR）激动剂。 了解更多
  50. Hydroxocobalamin (Vitamin B12a)
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    Hydroxocobalamin (Vitamin B12a)

    Catalog No. A10458
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    Hydroxocobalamin是维生素B12的生物活性形式。 当以每天2 ?g的剂量连续4天给药时，在贫血的小鼠模型中，红细胞的数量比对照增加了2.5倍。 了解更多

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分类
  1. Cytochrome P450 (59)
  2. PPAR (47)
  3. PDE (74)
  4. HSP (47)
  5. Hydroxylases (14)
  6. Factor Xa (17)
  7. MAO (30)
  8. DHFR (10)
  9. Dehydrogenases (27)
  10. Procollagen C-proteinase (1)
  11. Carbonic Anhydrase (12)
  12. LXR (13)
  13. FAAH (11)
  14. 15-PGDH (2)
  15. CETP (6)
  16. Ferroptosis (5)
  17. HMG-CoA Reductase (15)
  18. FXR (14)
  19. Isocitrate Dehydrogenase (IDH) (14)
  20. IDO (13)
  21. Retinoid Receptor (22)
  22. Lipase (12)
  23. Phospholipases (13)
  24. Lipoxygenase (13)
  25. AhR (6)
  26. NAMPT (9)
  27. GLUT (4)
  28. Antimetabolite (10)
  29. Lipid Metabolism (1)
  30. Neuronal Metabolism (1)
  31. SREBP (2)
  32. LDL (3)
  33. Foxo1 (2)
  34. DGAT (6)
  35. Farnesyl Transferase (6)
  36. CRM1 (7)
  37. Thioredoxin (2)
  38. Vitamin (31)
  39. Decarboxylase (3)
  40. ACLY (2)
  41. Fatty acid synthase (FASN) (7)
  42. Glucokinase (3)
  43. Lactate dehydrogenase A (LDHA) (1)
  44. Oxidative Phosphorylation (3)
  45. PFKFB3 (3)
  46. Ribonucleotide Reductase (2)
  47. Acetyl-CoA Carboxylase (6)
  48. Glucosidase (12)
  49. Phosphatase (6)
作用机制
  1. Inhibitor (抑制剂) (394)
  2. Agonist (激动剂) (66)
  3. Antagonist (拮抗剂) (22)
  4. Activator (激活剂) (11)
  5. Modulator (调节剂) (2)
  6. Blocker (阻断剂) (2)
  7. Inducer (诱导剂) (5)
  8. Substrate (底物) (4)
靶点
  1. 5-lipoxygenase (1)
  2. Carbonic Anhydrase (6)
  3. Carbonic Anhydrase I (3)
  4. Carbonic Anhydrase II (3)
  5. Carbonic Anhydrase IV (2)
  6. Carbonic Anhydrase IX (2)
  7. CETP (4)
  8. COX (1)
  9. COX-1 (1)
  10. COX-2 (2)
  11. DNMT (1)
  12. FTase (4)
  13. HDAC1 (1)
  14. HMG-CoA Reductase (9)
  15. HSP90 (1)
  16. KDM1A (LSD1) (1)
  17. MAO-A (1)
  18. MAO-B (1)
  19. PDE4 (1)
  20. PDE5 (1)
  21. Src (1)
  22. TNF-α (1)
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