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Cell Metabolism

产品 301 到 350 共 623个

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  1. MK-8245
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    MK-8245

    Catalog No. A11403
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    SCD 抑制剂
    MK-8245是肝脏靶向的硬脂酰CoA去饱和酶（SCD）抑制剂。MK-8245可用于治疗糖尿病和血脂异常。 了解更多
  2. Celastrol
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    Celastrol

    Catalog No. A10192
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    Celastrol是一种有效的蛋白酶抑制剂，有效且优先抑制胰凝乳蛋白酶样的纯化的20S proteasome的活性，IC50为2.5 μM。 了解更多
  3. Mycophenolate mofetil (CellCept)
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    Mycophenolate mofetil (CellCept)

    Catalog No. A10613
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    IMPDH 抑制剂
    Mycophenolate mofetil (CellCept)是嘌呤生物合成（特别是鸟嘌呤合成）中肌苷单磷酸脱氢酶（IMPDH）的可逆抑制剂，对T细胞和B细胞的生长是必需的。 了解更多
  4. Gossypol
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    Gossypol

    Catalog No. A10435
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    dehydrogenase inhibitor
    Gossypol是一种多酚醛，渗透细胞并作为几种脱氢酶的抑制剂。 了解更多
  5. Leflunomide
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    Leflunomide

    Catalog No. A10521
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    Dehydrogenase 抑制剂
    Leflunomide是一种嘧啶合成抑制剂，属于DMARD类药物。来氟米特用于缓解类风湿性关节炎引起的症状，如炎症、肿胀、僵硬和关节痛。 了解更多
  6. Gimeracil
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    Gimeracil

    Catalog No. A11682
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    Gimeracil是一种二氢脱氢酶的抑制剂，在双链断裂修复中，抑制早期同源重组。 了解更多
  7. CPI-613 (Devimistat)
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    CPI-613 (Devimistat)

    Catalog No. A11786
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    Dehydrogenase 抑制剂
    CPI-613是合成的α-硫辛酸硫辛酸类似物的对映异构体的外消旋混合物，具有潜在的化学预防和抗肿瘤活性。 了解更多
  8. Ranolazine
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    Ranolazine

    Catalog No. A10780
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    Ranolazine是部分脂肪酸氧化抑制剂，可将ATP的生产从脂肪酸转变为氧效率更高的碳水化合物氧化。 了解更多
  9. Disulfiram
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    Disulfiram

    Catalog No. A10320
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    Disulfiram是通过抑制乙醛脱氢酶来阻止体内酒精的加工，从而在消耗酒精时引起令人不快的反应。 了解更多
  10. Brequinar
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    Brequinar

    Catalog No. A12442
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    Dihydroorotate Dehydrogenase 抑制剂
    Brequinar是二氢乳清酸脱氢酶的抑制剂，二氢乳清酸脱氢酶是从头进行嘧啶生物合成的酶。 了解更多
  11. CGP 3466B maleate
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    CGP 3466B maleate

    Catalog No. A12385
    GAPDH 抑制剂
    CGP 3466B maleate是口服活性甘油醛-3-磷酸脱氢酶(gapdh)抑制剂。 了解更多
  12. ASP9521
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    ASP9521

    Catalog No. A14412
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    ASP9521是一种新型的，选择性的，可生物利用的羟类固醇脱氢酶5型抑制剂（17bHSD5，AKR1C3）。 了解更多
  13. Vidofludimus (4SC-101)
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    Vidofludimus (4SC-101)

    Catalog No. A12997
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    DHODH 抑制剂
    Vidofludimus是一种新型的口服活性强效DHODH抑制剂。对人DHODH的IC50为134 nM。 了解更多
  14. AZD4017
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    AZD4017

    Catalog No. A13542
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    HSD1 抑制剂
    AZD4017是一种有效的，选择性的，口服可生物利用的11b-HSD1抑制剂（11b-羟基类固醇脱氢酶1型抑制剂）。 了解更多
  15. Monoammoniumglycyrrhizinate
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    Monoammoniumglycyrrhizinate

    Catalog No. A14599
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    Monoammoniumglycyrrhizinate是甘草根的一种成分，具有重要的抗病毒活性，已显示可通过间接机制抑制11_αHSD2（11_α羟类固醇脱氢酶2型）的表达。 了解更多
  16. MK-8245 Trifluoroacetate
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    MK-8245 Trifluoroacetate

    Catalog No. A15170
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    Liver-targeting SCD 抑制剂?
    MK-8245 Trifluoroacetate是硬脂酰辅酶A去饱和酶（SCD）的肝靶向抑制剂，对人SCD1的IC50为1 nM，对大鼠SCD1和小鼠SCD1的IC50为3 nM，具有抗糖尿病和抗血脂异常的功效。 了解更多
  17. Alda 1
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    Alda 1

    Catalog No. A15805
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    ALDH2 Activator
    Alda 1是醛脱氢酶2（ALDH2）的激活剂。 了解更多
  18. NCT-501
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    NCT-501

    Catalog No. A15892
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    hALDH1 抑制剂?
    NCT-501是一种有效且选择性的醛脱氢酶1A1（ALDH1A1）抑制剂，IC50为40 nM。 了解更多
  19. AG-120
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    AG-120

    Catalog No. A15869
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    Dehydrogenase 抑制剂
    AG-120是1型异柠檬酸脱氢酶（IDH1）的抑制剂，具有潜在的抗肿瘤活性。 了解更多
  20. Trilostane
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    Trilostane

    Catalog No. A10949
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    Trilostane是用于治疗Cushing综合征的3β-羟基类固醇脱氢酶的抑制剂。 了解更多
  21. Fomepizole
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    Fomepizole

    Catalog No. A16164
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    alcohol dehydrogenase 抑制剂
    Fomepizole是一种醇脱氢酶抑制剂，用于治疗成年人的乙二醇和甲醇中毒。 了解更多
  22. CBR 5884
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    CBR 5884

    Catalog No. A16176
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    PHGDH 抑制剂
    CBR 5884是3-磷酸甘油酸脱氢酶（PHGDH）的抑制剂，可抑制细胞中3-磷酸甘油酸丝氨酸的合成，IC50值为33 uM。 了解更多
  23. CAY10566
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    CAY10566

    Catalog No. A16936
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    SCD1 抑制剂
    CAY10566是SCD1的强效和选择性抑制剂，在小鼠和人酶测定中的IC50值分别为4.5和26 nM。 了解更多
  24. A939572
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    A939572

    Catalog No. A13298
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    SCD1 inhibitor
    A939572 is a potent, and orally bioavailable stearoyl-CoA desaturase1 (SCD1) inhibitor with IC50 values of <4 nM and 37 nM for mSCD1 and hSCD1, respectively. 了解更多
  25. CVT-12012
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    CVT-12012

    Catalog No. A21447
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    SCD inhibitor
    CVT-12012 is a potent and orally bioavailable stearoyl-coA desaturase (SCD) inhibitor, with IC50s of 38 nM, 6.1 nM for rat microsomal and human HEPG2, respectively. 了解更多
  26. MF-438
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    MF-438

    Catalog No. A20963
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    SCD1 inhibitor
    MF-438 is a potent and orally bioavailable stearoyl-CoA desaturase 1 (SCD1) inhibitor with an EC50 of 2.3 nM for rSCD1. 了解更多
  27. Methotrexate (Abitrexate)
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    Methotrexate (Abitrexate)

    Catalog No. A10021
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    DHFR 抑制剂
    Methotrexate (Abitrexate)是一种抑制胸苷酸合成酶和从头嘌呤合成的细胞毒剂。 了解更多
  28. Pemetrexed disodium (Alimta)
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    Pemetrexed disodium (Alimta)

    Catalog No. A10707
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    Pemetrexed disodium (Alimta)是一种新型抗叶酸和抗代谢药物，作用于TS，DHFR和GARFT。 了解更多
  29. Aminopterin
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    Aminopterin

    Catalog No. A11787
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    Aminopterin是一种抗肿瘤药。它通过竞争二氢叶酸还原酶的叶酸结合位点而充当酶抑制剂。 了解更多
  30. Pemetrexed
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    Pemetrexed

    Catalog No. A12668
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    DHFR 抑制剂
    Pemetrexed 是一种具有多个靶标的新型抗叶酸药。作用于TS，DHFR和GARFT，Ki分别为1.3 nM，7.2 nM 和 65 nM。 了解更多
  31. Trimetrexate
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    Trimetrexate

    Catalog No. A12796
    Trimetrexate是喹唑啉衍生物。它是二氢叶酸还原酶抑制剂。 了解更多
  32. NSC 131463 (DAMPA)
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    NSC 131463 (DAMPA)

    Catalog No. A10655
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    DHFR 抑制剂
    NSC 131463 (DAMPA)是有效的二氢叶酸还原酶抑制剂，IC50为1 nM。 了解更多
  33. Pralatrexate
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    Pralatrexate

    Catalog No. A11522
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    DHFR 抑制剂
    Pralatrexate是一种抗叶酸剂(叶酸类似物代谢抑制剂),设计用于优先在癌细胞中积累。 了解更多
  34. Pemetrexed disodium hemipenta hydrate
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    Pemetrexed disodium hemipenta hydrate

    Catalog No. A15207
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    Pemetrexed disodium hemipenta hydrate是TS，DHFR和GARFT的新型抗叶酸和抗代谢药，Ki分别为1.3 nM，7.2 nM和65 nM。 了解更多
  35. Diaveridine
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    Diaveridine

    Catalog No. A17000
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    DHFR 抑制剂
    Diaveridine（EGIS-5645）是一种二氢叶酸还原酶（DHFR）抑制剂，其野生型DHFR的Ki值为11.5 nM，同时也是一种抗菌剂。 了解更多
  36. WR99210
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    WR99210

    Catalog No. A18837
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    DHFR 抑制剂
    WR99210 is a effective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of <0.075 nM. WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains. 了解更多
  37. Safinamide Mesylate (FCE28073)
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    Safinamide Mesylate (FCE28073)

    Catalog No. A10818
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    MAO 抑制剂
    Safinamide Mesylate是沙芬酰胺的甲磺酸盐，可选择性和可逆地抑制MAO-B，IC50为0.45μM。 了解更多
  38. Rasagiline mesylate
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    Rasagiline mesylate

    Catalog No. A11722
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    Monoamine oxidase 抑制剂
    Rasagiline mesylate是一种不可逆的单胺氧化酶抑制剂，在早期帕金森氏病中用作单一疗法，在较晚期的病例中用作辅助疗法。对于B型MAO，它对A型的选择性是14倍。 了解更多
  39. SL251188
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    SL251188

    Catalog No. A11777
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    MAO-B 抑制剂
    SL-251188是恶唑烷酮衍生物，在狒狒中被表征为放射性配体，可使用正电子发射断层扫描（PET）在体内可视化MAO-B。 了解更多
  40. Moclobemide
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    Moclobemide

    Catalog No. A11885
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    MAO 抑制剂
    Moclobemide是单胺氧化酶A（MAO-A）的可逆和选择性抑制剂。 了解更多
  41. Bifemelane HCl
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    Bifemelane HCl

    Catalog No. A13353
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    MAO 抑制剂
    Bifemelane hydrochloride是抗抑郁的MAO抑制剂。逆转丁苯那嗪在小鼠中引起的僵直，并增加MPTP处理的mar猴的自发活动。 了解更多
  42. Tranylcypromine hydrochloride
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    Tranylcypromine hydrochloride

    Catalog No. A13358
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    LSD1/BHC110 & MAO 抑制剂
    Tranylcypromine hydrochloride是一种非选择性的MAO-A/B抑制剂。 了解更多
  43. Safinamide
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    Safinamide

    Catalog No. A13294
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    MAO-B 抑制剂
    Safinamide是一种高度选择性和可逆的B型单胺氧化酶（MAO-B）抑制剂，可增加新纹状体多巴胺的浓度。 了解更多
  44. RN-1 2HCl
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    RN-1 2HCl

    Catalog No. A14344
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    MAO 抑制剂
    RN-1 2HCl对LSD1的选择性优于单胺氧化酶(MAO)-A和MAO-B（在辣根过氧化物酶偶联测定中，IC50值分别为70 nM，0.51和2.79 μM）。 了解更多
  45. Clorgyline hydrochloride
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    Clorgyline hydrochloride

    Catalog No. A17357
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    monoamine oxidase A inhibitor
    Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research; structurally related to Pargyline. 了解更多
  46. Isocarboxazid
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    Isocarboxazid

    Catalog No. A17887
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    monoamine oxidase inhibitor
    Isocarboxazid is a non-selective and irreversible inhibitor of monoamine oxidase, with an IC50 of 4.8 μM for rat brain monoamine oxidase in vitro. 了解更多
  47. Rasagiline 13C3 mesylate racemic
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    Rasagiline 13C3 mesylate racemic

    Catalog No. A21350
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    Monoamine oxidase inhibitor
    Rasagiline 13C3 mesylate racemic is the deuterium labeled Rasagiline, which is an irreversible inhibitor of monoamine oxidase. 了解更多
  48. PAT-1251 Hydrochloride
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    PAT-1251 Hydrochloride

    Catalog No. A21969
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    LOXL2 inhibitor
    PAT-1251 Hydrochloride is a potent, selective and oral lysyl oxidase-like 2 (LOXL2) inhibitor, with IC50s of 0.71 and 1.17 μM for hLOXL2 and hLOXL3, respectively, and also potently inhibits mouse, rat, and dog LOXL2 (IC50s, 0.10, 0.12, and 0.16 μM, respectively). 了解更多
  49. Rasagiline
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    Rasagiline

    Catalog No. A11111
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    MAO B 抑制剂
    Rasagiline是MAO-B（单胺氧化酶-B）的选择性不可逆抑制剂。 了解更多
  50. Hordenine
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    Hordenine

    Catalog No. A10454
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    MAO-B 抑制剂
    Hordenine是一种苯乙胺生物碱，具有抗菌和抗生素特性。 了解更多

产品 301 到 350 共 623个

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分类
  1. Cytochrome P450 (59)
  2. PPAR (47)
  3. PDE (74)
  4. HSP (47)
  5. Hydroxylases (14)
  6. Factor Xa (17)
  7. MAO (30)
  8. DHFR (10)
  9. Dehydrogenases (27)
  10. Procollagen C-proteinase (1)
  11. Carbonic Anhydrase (12)
  12. LXR (13)
  13. FAAH (11)
  14. 15-PGDH (2)
  15. CETP (6)
  16. Ferroptosis (5)
  17. HMG-CoA Reductase (15)
  18. FXR (14)
  19. Isocitrate Dehydrogenase (IDH) (14)
  20. IDO (13)
  21. Retinoid Receptor (22)
  22. Lipase (12)
  23. Phospholipases (13)
  24. Lipoxygenase (13)
  25. AhR (6)
  26. NAMPT (9)
  27. GLUT (4)
  28. Antimetabolite (10)
  29. Lipid Metabolism (1)
  30. Neuronal Metabolism (1)
  31. SREBP (2)
  32. LDL (3)
  33. Foxo1 (2)
  34. DGAT (6)
  35. Farnesyl Transferase (6)
  36. CRM1 (7)
  37. Thioredoxin (2)
  38. Vitamin (31)
  39. Decarboxylase (3)
  40. ACLY (2)
  41. Fatty acid synthase (FASN) (7)
  42. Glucokinase (3)
  43. Lactate dehydrogenase A (LDHA) (1)
  44. Oxidative Phosphorylation (3)
  45. PFKFB3 (3)
  46. Ribonucleotide Reductase (2)
  47. Acetyl-CoA Carboxylase (6)
  48. Glucosidase (12)
  49. Phosphatase (6)
作用机制
  1. Inhibitor (抑制剂) (394)
  2. Agonist (激动剂) (66)
  3. Antagonist (拮抗剂) (22)
  4. Activator (激活剂) (11)
  5. Modulator (调节剂) (2)
  6. Blocker (阻断剂) (2)
  7. Inducer (诱导剂) (5)
  8. Substrate (底物) (4)
靶点
  1. 5-lipoxygenase (1)
  2. Carbonic Anhydrase (6)
  3. Carbonic Anhydrase I (3)
  4. Carbonic Anhydrase II (3)
  5. Carbonic Anhydrase IV (2)
  6. Carbonic Anhydrase IX (2)
  7. CETP (4)
  8. COX (1)
  9. COX-1 (1)
  10. COX-2 (2)
  11. DNMT (1)
  12. FTase (4)
  13. HDAC1 (1)
  14. HMG-CoA Reductase (9)
  15. HSP90 (1)
  16. KDM1A (LSD1) (1)
  17. MAO-A (1)
  18. MAO-B (1)
  19. PDE4 (1)
  20. PDE5 (1)
  21. Src (1)
  22. TNF-α (1)
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