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Cell Metabolism

Cell Metabolism

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UM171

Catalog No. A15913
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HSC agonist

UM171 is a potent agonist of human hematopoietic stem cell renewal, independently of AhR suppression. 了解更多

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ITE

Catalog No. A12565
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AhR agonist

ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity. 了解更多

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FICZ

Catalog No. A21452
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AhR agonist

FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM. 了解更多

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AM 580

Catalog No. A11792
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RARα 激动剂

AM 580是视黄酸的类似物，可作为选择性RARα激动剂。了解更多

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CD 437

Catalog No. A11793
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RARγ-selective 激动剂

CD 437是一种合成类维生素A，是一种RARγ选择性激动剂。了解更多

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TTNPB

Catalog No. A13007
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RAR 激动剂

TTNPB增强了化学诱导的多能干细胞（CiPSC）的重编程效率。了解更多

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Fenretinide

Catalog No. A12163
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RAR 激动剂

Fenretinide是一种合成类视黄醇激动剂。它是一种体内半衰期长的抗增殖、抗氧化和抗癌药物。了解更多

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LG 100268

Catalog No. A14127
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RXR 激动剂

LG 100268是一种有效的RXR激动剂，可用于评估非胰岛素依赖型（II型）糖尿病（NIDDM）。了解更多

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Tretinoin

Catalog No. A10944
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RAR 激动剂

Tretinoin 是视黄酸受体的内源性激动剂，RAR-α，RAR-β和RAR-γ受体的IC50值为14 nM。了解更多

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Tamibarotene

Catalog No. A11589
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RARα 激动剂

Tamibarotene是一种是视黄酸受体α/β (RARα/β)的激动剂，在体外可诱导HL-60细胞分化（ED50 = 0.79 nM）和凋亡。了解更多

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AGN 194310

Catalog No. A16292
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pan-RARs 激动剂

AGN 194310是一种有效的选择性Pan-RARs激动剂，对于RARα/β/γ的Kd值分别为3/2/5 nM。了解更多

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AGN 195183

Catalog No. A16293
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RARα 激动剂

AGN 195183是RARα（Kd = 3 nM）的强效选择性激动剂，相对于AGN 193836具有增强的结合选择性。对RARβ/γ无活性。了解更多

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AGN 205327

Catalog No. A16295
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RAR 激动剂

AGN 205327是一种有效的合成RARs激动剂，对RARα/β/γ的EC50分别为3766/734/32 nM；对RXR无抑制作用。了解更多

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AC-55649

Catalog No. A20078
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Human RARβ2 receptor agonist

AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9. 了解更多

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WYC-209

Catalog No. A19001
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RAR agonist

WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. 了解更多

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GW4064

Catalog No. A11141
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FXR 激动剂

GW4064是选择性的非甾体类法尼醇X受体（FXR）激动剂（EC50 = 15 nM）。了解更多

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- Dong-Hyun Kim, .et al. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD, Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
- Takae K, .et al. Evidence for the involvement of FXR signaling in ovarian granulosa cell function, J Reprod Dev, 2018, Nov 16 PMID: 30449821
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WAY-362450

Catalog No. A11186
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FXR 激动剂

WAY-362450是一种高效，选择性和口服可生物利用的法呢类X受体（FXR）激动剂（EC50：4 nM，eff = 149％）。了解更多

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- Dong-Hyun Kim, .et al. The critical role of FXR is associated with the regulation of autophagy and apoptosis in the progression of AKI to CKD, Cell Death Dis, 2021, Apr; 12(4): 320 PMID: 33767132
- Dong-Hyun Kim, .et al. Src-mediated crosstalk between FXR and YAP protects against renal fibrosis, FASEB J, 2019, Jul 12:fj201900325R PMID: 31298930
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Lithocholic acid

Catalog No. A12547
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FXR 激动剂

Lithocholic acid是胆汁酸，用作去污剂以溶解脂肪以供吸收。了解更多

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Obeticholic Acid

Catalog No. A13866
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FXR 激动剂

Obeticholic Acid是一种有效的选择性法呢类X受体（FXR）激动剂，EC50为99 nM。了解更多

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- Tomasz Kostrzewski, .et al. A Microphysiological System for Studying Nonalcoholic Steatohepatitis, Hepatol Commun, 2019, 13 November
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LY2562175

Catalog No. A17016
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FXR 激动剂

LY2562175是体外有效的选择性FXR激动剂，其EC50值为193 nM。具有强大的脂质调节特性，可降低临床前物种中的LDL和甘油三酸酯，同时提高HDL。了解更多

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Px-104

Catalog No. A16999
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FXR 激动剂

Px-104，也称为Px-102，是一种潜在的法呢素X受体（FXR）激动剂，可用于治疗非酒精性脂肪肝。了解更多

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PX20606 trans-isomer

Catalog No. A16997
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FXR 激动剂

PX20606 trans-isomer在小鼠和猴子中诱导高密度脂蛋白介导的跨肝胆固醇外流，并预防胆固醇酯转移蛋白转基因低密度脂蛋白受体(-/-)mice的动脉粥样硬化。了解更多

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Cilofexor

Catalog No. A13143
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FXR agonist

Cilofexor (GS-9674) is a farnesoid X receptor (FXR) agonist. 了解更多

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Nidufexor

Catalog No. A12625
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FXR agonist

Nidufexor is a farnesoid X receptor (FXR) agonist. 了解更多

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INT-767

Catalog No. A21494
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dual FXR/TGR5 agonist

INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. 了解更多

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Fexaramine

Catalog No. A21771
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FXR agonist

Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds. 了解更多

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GW3965 HCl

Catalog No. A11204
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LXR-like receptors 激动剂

GW3965 HCl是一种选择性的口服活性肝X受体（LXR）完全激动剂。了解更多

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- Mohácsik P, .et al. A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action, Endocrinology, 2018, Feb 1;159(2):1159-1171 PMID: 29253128
- Pencheva N, .et al. Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation., Cell., 2014, 156(5):986-1001 PMID: 24581497
- Bin Dong, .et al. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway, J Lipid Res., 2013, May; 54(5): 1241-1254. PMID: 23427282
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T0901317

Catalog No. A12652
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LXR/FXR 激动剂

T0901317是有效的，高亲和力的肝X受体（LXR）激动剂（EC50~50 nM，LXR-β和LXR-β的Kd值分别为7和22 nM）。了解更多

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- Tian Yongsong, .et al. Tritium hydrogen-isotope exchange with electron-poor tertiary benzenesulfonamide moiety; application in late-stage labeling of T0901317, J Labelled Comp Radiopharm, 2022, Feb;65(2):36-44 PMID: 34957593
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GW3965

Catalog No. A15100
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Liver X Receptor 激动剂

GW3965是hLXRα和hLXRβ的有效选择性LXR激动剂，EC50分别为190和30 nM。了解更多

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- B Dong ,etc. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway. Journal of lipid research, 2013, 54(5), 1241-1254.
- N Pencheva ,etc. Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation. Cell, 2014, 156(5), 986-1001.
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Sobetirome

Catalog No. A15241
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TRβ 激动剂

Sobetirome是一种甲状腺激素受体β（TRβ）特异性激动剂，Sobetirome设计用于选择性结合TRβ-1，EC50为0.16 μM。了解更多

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SR9243

Catalog No. A15535
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LXR 激动剂

SR9243是有效的选择性LXR反向激动剂。SR9243通过抑制脂质产生和Warburg效应杀死癌细胞。它在多种类型的癌症中诱导细胞死亡，并且不会引起副作用，而这些副作用已使先前针对这些过程的尝试脱轨。了解更多

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SR9238

Catalog No. A15763
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LXR Inverse 激动剂

SR9238是有效的选择性LXR反向激动剂（LXRβ和LXRα的IC50值分别为43和214 nM）。了解更多

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LXR-623

Catalog No. A21366
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LXRα and full LXRβ agonist

LXR-623 is a brain-penetrant partial LXRα and full LXRβ agonist, with IC50s of 24 nM and 179 nM, respectively. 了解更多

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RGX-104 free Acid

Catalog No. A21513
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LXR agonist

RGX-104 free Acid is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. 了解更多

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AZ876

Catalog No. A21026
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LXR agonist

AZ876 is a novel high-affinity LXR agonist. 了解更多

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Rosiglitazone maleate

Catalog No. A10809
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PPAR 激动剂

Rosiglitazone maleate是一种噻唑烷二酮类抗高血糖药，是PPARγ的高亲和、选择性的激动剂。了解更多

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Pioglitazone (Actos)

Catalog No. A11680
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PPARγ 激动剂

Pioglitazone (Actos)是选择性刺激核受体过氧化物酶体增殖物激活的受体γ（PPAR-γ），并在较小程度上刺激PPAR-α。了解更多

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Rosiglitazone (BRL-49653)

Catalog No. A10807
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PPAR 激动剂

Rosiglitazone (BRL-49653)是有效的降糖药，也是有效的噻唑烷二酮类胰岛素增敏剂，在大鼠，3T3-L1和人体脂肪细胞中IC50分别为12，4和9 nM。Rosiglitazone是PPAR-gamma的配体，对PPAR-alpha没有结合力。了解更多

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Troglitazone

Catalog No. A11981
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PPARγ 激动剂

Troglitazone是一种选择性PPARγ受体激动剂（鼠和人PPARγ受体的EC50值分别为780和555 nM）。了解更多

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- Julien Allard, .et al. Drug-induced Hepatic Steatosis in Absence of Severe Mitochondrial Dysfunction in HepaRG Cells: Proof of Multiple Mechanism-Based Toxicity, Cell Biol Toxicol, 2020, Jun 14 PMID: 32535746
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GW 7647

Catalog No. A11982
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PPARα 激动剂

GW 7647是一种有效且高度选择性的PPARα激动剂（人PPARα，PPARγ和PPARδ受体的EC50值分别为6、1100和6200 nM）。了解更多

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L-165,041

Catalog No. A11983
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PPARδ 激动剂

L-165,041是有效的PPARδ激动剂（Ki = 6 nM）；与其他亚型相比，对小鼠和人类PPARδ受体的选择性显示> 100倍。了解更多

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pirinixic acid (WY 14643)

Catalog No. A12360
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PPARα 激动剂

pirinixic acid (WY 14643)是一种高效pparα激动剂。了解更多

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GW 501516

Catalog No. A11437
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PPARδ receptor 激动剂

GW501516是一种合成pparδ特异性激动剂，对pparδ (ki=1.1 nm)显示出高亲和力，其选择性超过pparα和pparγ的1000倍。了解更多

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Inolitazone dihydrochloride

Catalog No. A15129
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PPARγ 激动剂

Inolitazone dihydrochloride是一种新型的高亲和力PPARγ激动剂，可激活PPARγ，其EC50约为罗格列酮的EC50，对RIE细胞无影响。了解更多

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Bezafibrate

Catalog No. A16307
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PPAR 激动剂

Bezafibrate是首个经过临床测试的双重和泛PPAR共同激动剂。了解更多

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Clofibric Acid

Catalog No. A16463
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PPARα 激动剂

Clofibric Acid是PPARα激动剂和降血脂药。了解更多

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Etofylline

Catalog No. A17491
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PPAR agonist

Etofylline, also known as BRN-0251760, is a peroxisome proliferator-activated receptor (PPAR) agonist used to treat respiratory and cardiovascular disorders. Etofylline is often used as a bronchodilator. 了解更多

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BR102375

Catalog No. A18849
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PPAR γ agonist

BR102375 is a non-TZD peroxisome proliferator-activated receptor γ (PPAR γ) full agonist for the treatment of type 2 diabetes, reveals EC50 value of 0.28?μM and Amax ratio?of 98%. 了解更多

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VCE-004.8

Catalog No. A18549
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PPARγ and CB2 receptor dual agonist

VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity. 了解更多

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LJ570

Catalog No. A20081
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PPARα/PPARγ dual agonist

LJ570 is a PPARα/PPARγ dual agonist with EC50s of 1.05 and 0.12 μM, respectively. 了解更多

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