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CHZ868是一种有效的选择性II型JAK抑制剂，在JAK抑制剂持续性细胞，鼠类MPN模型和MPN患者样品中显示出活性。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.62 mL | 118.09 mL | 236.17 mL |
| 0.5 mM | 4.72 mL | 23.62 mL | 47.23 mL |
| 1 mM | 2.36 mL | 11.81 mL | 23.62 mL |
| 5 mM | 0.47 mL | 2.36 mL | 4.72 mL |
*The above data is based on the productmolecular weight 423.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15937 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 423.42 |
| Formula | C22H19F2N5O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1895895-38-1 |
| Synonyms | CHZ 868, CHZ-868 |
| SMILES | CC(NC1=NC=CC(OC2=CC=C3N(C)C(NC4=CC=C(F)C=C4F)=NC3=C2C)=C1)=O |
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