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CL-387785是EGFR的不可逆抑制剂，IC50为370+/-120 pM；能够在功能水平上克服由T790M突变引起的抗药性。
靶点信息
| EGFR | ||||
| 370 pM |
| In vitro | DMSO | Warmed: 61 mg/mL (160 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.23 mL | 131.15 mL | 262.31 mL |
| 0.5 mM | 5.25 mL | 26.23 mL | 52.46 mL |
| 1 mM | 2.62 mL | 13.12 mL | 26.23 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.25 mL |
*The above data is based on the productmolecular weight 381.23. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13146 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 381.23 |
| Formula | C18H13BrN4O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 194423-06-8 |
| Synonyms | WAY-EKI 785, CL387785, CL 387785, EKI785, WAY-EKI785, EKI 785, EKI-785 |
| SMILES | CC#C/C(O)=N/C1=CC(C(NC2=CC=CC(Br)=C2)=NC=N3)=C3C=C1 |
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