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Clomipramine HCl是下列转运蛋白的阻滞剂：5-羟色胺转运蛋白 (SERT)(Ki = 0.14 nM)，去甲肾上腺素转运蛋白（NET）(Ki = 54 nM)，多巴胺转运蛋白（DAT）(Ki = 3，020 nM)，甘氨酸转运蛋白（GlyT/LeuT）。
靶点信息
| 5-HT | ||||
| In vitro | DMSO | 60 mg/mL (170.79 mM) | |
| Water | 60 mg/mL (170.79 mM) | ||
| Ethanol | 60 mg/mL (170.79 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.46 mL | 142.32 mL | 284.65 mL |
| 0.5 mM | 5.69 mL | 28.46 mL | 56.93 mL |
| 1 mM | 2.85 mL | 14.23 mL | 28.46 mL |
| 5 mM | 0.57 mL | 2.85 mL | 5.69 mL |
*The above data is based on the productmolecular weight 351.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10231 |
|---|---|
| 作用机制 | Agonist (激动剂) |
| M. Wt | 351.31 |
| Formula | C19H23ClN2.HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 17321-77-6 |
| SMILES | CN(C)CCCN1C2=CC=CC=C2CCC3=C1C=C(C=C3)Cl.Cl |
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