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Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 15.45 mL | 77.23 mL | 154.47 mL |
| 0.5 mM | 3.09 mL | 15.45 mL | 30.89 mL |
| 1 mM | 1.54 mL | 7.72 mL | 15.45 mL |
| 5 mM | 0.31 mL | 1.54 mL | 3.09 mL |
*The above data is based on the productmolecular weight 647.38. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A18033 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 647.38 |
| Formula | C25H25F3IN3O6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1369665-02-0 |
| Synonyms | GDC-0973 hemifumarate, GDC0973, GDC 0973; XL-518 hemifumarate, XL518, XL 518 |
| SMILES | OC1([C@H]2NCCCC2)CN(C1)C(C3=C(C(F)=C(C=C3)F)NC4=C(C=C(C=C4)I)F)=O.O=C(O)/C=C/C(O)=O.[0.5] |
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