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CPI-268456是含溴结构域蛋白4（BRD4）的配体。 它与BRD4结合（无细胞试验中IC50 = <0.5 ?M），并抑制THP-1细胞中LPS诱导的IL-6分泌（IC50 = <0.5 ?M）。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 25.06 mL | 125.3 mL | 250.6 mL |
| 0.5 mM | 5.01 mL | 25.06 mL | 50.12 mL |
| 1 mM | 2.51 mL | 12.53 mL | 25.06 mL |
| 5 mM | 0.5 mL | 2.51 mL | 5.01 mL |
*The above data is based on the productmolecular weight 399.05. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15828 |
|---|---|
| M. Wt | 399.05 |
| Formula | C20H15Cl2N3O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1380087-86-4 |
| Synonyms | CPI 268456, CPI268456 |
| SMILES | C(N)(=O)C[C@@H]1N=C(C2=CC=C(Cl)C=C2)C2=CC(Cl)=CC=C2C2C(C)=NOC=21 |
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