CRM1
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Selinexor (KPT-330)
Catalog No. A12582 CRM1 抑制剂CRM1(XPO1)介导的核输出的KPT-330抑制剂在T细胞急性淋巴细胞白血病和急性骨髓性白血病的临床前模型中具有选择性的抗白血病活性。 了解更多 -
Piperlongumine
Catalog No. A14124 TrxR1/CRM1 抑制剂Piperlongumine,存在于胡椒科植物荜茇中的一种天然生物碱,能够增加reactive oxygen species (ROS)水平,并选择性杀死癌细胞。它还是TrxR1的直接抑制剂,对胃癌具有抑制活性;一种新型的CRM1抑制剂;在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。 了解更多 -
KPT276
Catalog No. A16341 -
Eltanexor Z-isomer
Catalog No. A21786 CRM1 inhibitorEltanexor Z-isomer (KPT-8602 Z-isomer) is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor. 了解更多 -
Leptomycin B
Catalog No. A20985 nuclear export receptor CRM1 inhibitorLeptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle. 了解更多