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CVT-313是一种有效，选择性，可逆且具有ATP竞争性的CDK2抑制剂（对于Cdk2/A和Cdk2/E，IC50 = 0.5 uM；对于Cdk1/B为4.2 uM；对于Cdk4/D1为215 uM）。
| In vitro | DMSO | 73 mg/mL (182.28 mM) | |
| Water | Insoluble | ||
| Ethanol | 73 mg/mL (182.28 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.97 mL | 124.85 mL | 249.71 mL |
| 0.5 mM | 4.99 mL | 24.97 mL | 49.94 mL |
| 1 mM | 2.5 mL | 12.49 mL | 24.97 mL |
| 5 mM | 0.5 mL | 2.5 mL | 4.99 mL |
*The above data is based on the productmolecular weight 400.47. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15054 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 400.47 |
| Formula | C20H28N6O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 199986-75-9 |
| Synonyms | CVT 313, NG 26, CVT313, NG26, NG-26 |
| SMILES | CC(C)N1C=NC2=C1N=C(N=C2NCC3=CC=C(C=C3)OC)N(CCO)CCO |
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