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CX-5461是RNA聚合酶I（Pol I）的一流的非遗传毒性小分子靶向抑制剂，可激活p53途径而不会引起DNA损伤。
靶点信息
| A375 | MIA PaCa-2 | Pol I-driven transcription of rRNA (HCT-116, A375, MIA PaCa-2 cells) | HCT-116 | |
| 58 nM(ED50) | 74 nM(ED50) | 142 nM | 167 nM(ED50) |
| In vitro | DMSO | <1 mg/mL | |
| Water | Insoluble | ||
| Ethanol | DMF: Warmed: 3 mg/mL (5.84 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.47 mL | 97.35 mL | 194.7 mL |
| 0.5 mM | 3.89 mL | 19.47 mL | 38.94 mL |
| 1 mM | 1.95 mL | 9.74 mL | 19.47 mL |
| 5 mM | 0.39 mL | 1.95 mL | 3.89 mL |
*The above data is based on the productmolecular weight 513.6. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11065 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 513.6 |
| Formula | C27H27N7O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1138549-36-6 |
| Synonyms | CX5461 |
| SMILES | CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C |
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