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Cell Metabolism /
Cytochrome P450

Cytochrome P450

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PF 4981517

Catalog No. A12544
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CYP3A4 抑制剂

PF 4981517是一种有效且选择性的CYP3A4抑制剂（CYP3A4，CYP3A5和CYP3A7的IC50值分别为0.03、17和70 μM）。了解更多

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Ozagrel(OKY-046)

Catalog No. A10688
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TXAS 抑制剂

Ozagrel(OKY-046)是一种有效的选择性血栓烷A2合成酶抑制剂，IC50为4 nM。了解更多

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ABT

Catalog No. A13361
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Cytochrome P450 抑制剂

ABT (1-Aminobenzotriazole)是（CYP）细胞色素P-450和氯过氧化物酶的自杀底物。了解更多

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TAK-700 Salt (Orteronel Salt)

Catalog No. A13515
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CYP17A1/androgen synthesis 抑制剂

TAK-700 Salt (Orteronel Salt)是一种雄激素合成抑制剂。它选择性地抑制在睾丸，肾上腺和前列腺肿瘤组织中表达的酶CYP17A。了解更多

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Choline Fenofibrate

Catalog No. A15044
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CYP2C19/CYP2B6 抑制剂

Choline Fenofibrate (ABT-335)是非诺贝特酸的胆碱盐，与瑞舒伐他汀联合用于治疗血脂异常。了解更多

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Azathramycin

Catalog No. A15010
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CYP3A4 抑制剂

Azathramycin是一种抗生素。阿奇霉素与细菌核糖体的50S亚基结合，从而抑制mRNA的翻译。了解更多

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Benzbromarone

Catalog No. A16201
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CYP2C9 抑制剂

Benzbromarone是一种CYP2C9抑制剂，它以19.3 nM的Ki值与CYP2C9结合。了解更多

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TAK-700 (Orteronel)

Catalog No. A11044
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CYP17A1 抑制剂

TAK-700 (Orteronel)是一种口服非甾体雄激素合成抑制剂，可选择性抑制17,20裂解酶。了解更多

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Voriconazole (Vfend)

Catalog No. A10978
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CYP17 抑制剂

Voriconazole (Vfend)是一种三唑抗真菌剂，可以冻干粉的形式用于静脉输注溶液。了解更多

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Abiraterone (CB-7598)

Catalog No. A10020
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CYP17 抑制剂

Abiraterone (CB-7598)是一种有效CYP17抑制剂，20裂合酶（CYP17A1）。了解更多

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Abiraterone Acetate (CB7630)

Catalog No. A11058
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CYP17 抑制剂

Abiraterone Acetate是Abiraterone的醋酸盐形式，是一种甾体类细胞色素CYP17抑制剂。了解更多

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Avasimibe (CI-1011)

Catalog No. A10102
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CYP17 抑制剂

Avasimibe (CI-1011)是口服可生物利用的酰基辅酶A：胆固醇O-酰基转移酶（ACAT）抑制剂，IC50分别为2.9 μM， 13.9 μM和26.5 μM。了解更多

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- Yuyan Zhu, .et al. Pharmacological inhibition of acyl-coenzyme A:cholesterol acyltransferase alleviates obesity and insulin resistance in diet-induced obese mice by regulating food intake, Metabolism, 2021, Oct;123:154861 PMID: 34371065
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TOK-001 (Galeterone)

Catalog No. A11138
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CYP17 抑制剂

TOK-001 (Galeterone)既是雄激素受体拮抗剂又是CYP17A1抑制剂。了解更多

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Alizarin

Catalog No. A10054
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CYP17 抑制剂

Alizarin 在生物学研究中被新颖地用作染色剂，因为它可以将游离钙和某些钙化合物染成红色或浅紫色。了解更多

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- Ryota Kitakami, .et al. Inhibitory activities of anthraquinone and xanthone derivatives against transthyretin amyloidogenesis, Bioorg Med Chem, 2021, Jun 26;44:116292 PMID: 34225167
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Apigenin

Catalog No. A10081
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Protein kinase 抑制剂

Apigenin是中央苯并二氮杂central受体的配体，其Ki为4μM竞争性抑制氟硝西epa的结合，发挥抗焦虑和轻微的镇静作用。了解更多

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Baicalein

Catalog No. A10120
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Lipoxygenase 抑制剂

Baicalein是一种类黄酮，最初从黄cut的根中分离出来。Baicalein抑制脂质过氧化 (通过TBARS的产生评估)，IC50值为5 ?M。了解更多

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Posaconazole

Catalog No. A10744
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CYP3A4 抑制剂

Posaconazole主要是CYP3A4的抑制剂，但不抑制其他CYP酶的活性。也是甾醇C14+脱甲基酶抑制剂的抑制剂，IC50为0.25μM。泊沙康唑的终末消除半衰期中位数为15-35小时。了解更多

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Ketoconazole

Catalog No. A10498
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P450 抑制剂

ketoconazole作为抗真菌药在结构上类似于咪唑，并干扰真菌细胞膜组成成分麦角甾醇以及某些酶的真菌合成。了解更多

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Cobicistat (GS-9350)

Catalog No. A11277
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CYP3A 抑制剂

Cobicistat (GS-9350)是有效，选择性的细胞色素酶P450 3A (CYP3A)抑制剂，包括重要的cyp3a4亚型。它还抑制肠道转运蛋白，增加几种hiv药物的整体吸收，包括atazanavir、darunavir和tenofovir alafenamide延胡索酸盐。了解更多

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Liarozole dihydrochloride

Catalog No. A21853
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CYP450 dependent inhibitor

Liarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). 了解更多

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Seviteronel

Catalog No. A20996
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CYP17 lyase inhibitor

Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. 了解更多

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Veledimex

Catalog No. A21011
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CYP3A4/5 inhibitor and substrate

Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5. 了解更多

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Bergaptol

Catalog No. A12303
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CYP3A4 enzyme inhibitor

Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties. 了解更多

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CYP17-IN-1

Catalog No. A12622
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CYP17 inhibitor

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM. 了解更多

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Sulfaphenazole

Catalog No. A17283
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CYP2C9 inhibitor

Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. 了解更多

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Efavirenz

Catalog No. A15826
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cytochrome P450 抑制剂

Efavirenz是一种非核苷类逆转录酶抑制剂（NNRTI）。了解更多

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Talarozole R enantiomer

Catalog No. A13113
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Cytochrome P450 抑制剂

Talarozole R enantiomer 通过阻断细胞色素P450酶同工酶CYP26（一种视黄酸羟化酶）来抑制视黄酸的代谢。了解更多

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Haloperidol (Haldol)

Catalog No. A10446
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CYP2D6 抑制剂

Haloperidol (Haldol)是一种抗精神病药和丁二酮。了解更多

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Clarithromycin

Catalog No. A10225
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cytochrome P4503A4 抑制剂

Clarithromycin是一种大环内酯类抗生素。它通过干扰细菌的蛋白质合成来防止细菌生长。了解更多

Product Citations (4)

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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347

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